Development of unique cytotoxic chimeric antigen receptors based on human scFv targeting B7H6

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity

(2016) R C Lynn et al.   LEUKEMIA

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

(2015) X. Liu et al.   CANCER RESEARCH

B7H6-specific chimeric antigen receptors lead to tumor elimination and host antitumor immunity

(2015) M-R Wu et al.   GENE THERAPY

Tumor Therapeutics Work as Stress Inducers to Enhance Tumor Sensitivity to Natural Killer (NK) Cell Cytolysis by Up-regulating NKp30 Ligand B7-H6

(2015) Guoshuai Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B7H6-Specific Bispecific T Cell Engagers Lead to Tumor Elimination and Host Antitumor Immunity

(2015) Ming-Ru Wu et al.   JOURNAL OF IMMUNOLOGY

Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production

(2015) Maryam Salimi et al.   JOURNAL OF IMMUNOLOGY

Antibody humanization by structure-based computational protein design

(2015) Yoonjoo Choi et al.   mAbs

NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure

(2015) Yong Zou et al.   PLoS One

Directed Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies

(2015) Sebastian K. Grimm et al.   PLoS One

Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane

(2014) S. E. James et al.   JOURNAL OF IMMUNOLOGY

Target Antigen Density Governs the Efficacy of Anti–CD20-CD28-CD3 ζ Chimeric Antigen Receptor–Modified Effector CD8+T Cells

(2014) Keisuke Watanabe et al.   JOURNAL OF IMMUNOLOGY

The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity

(2014) M. Hudecek et al.   Cancer Immunology Research

Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions

(2013) J. Matta et al.   BLOOD

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

(2013) N. Fiegler et al.   BLOOD

Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells

(2013) M. Hudecek et al.   CLINICAL CANCER RESEARCH

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

(2013) Vibha Jawa et al.   CLINICAL IMMUNOLOGY

Beyond humanization and de-immunization: tolerization as a method for reducing the immunogenicity of biologics

(2013) Anne S De Groot et al.   Expert Review of Clinical Pharmacology

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

(2012) W. Haso et al.   BLOOD

An NKp30-Based Chimeric Antigen Receptor Promotes T Cell Effector Functions and Antitumor Efficacy In Vivo

(2012) T. Zhang et al.   JOURNAL OF IMMUNOLOGY

Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6

(2011) Yili Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimization algorithms for functional deimmunization of therapeutic proteins

(2010) Andrew S Parker et al.   BMC BIOINFORMATICS

CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack

(2010) M Chmielewski et al.   GENE THERAPY

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Highly avid magnetic bead capture: An efficient selection method for de novo protein engineering utilizing yeast surface display

(2009) Margaret Ackerman et al.   BIOTECHNOLOGY PROGRESS

Affinity and Avidity in Antibody-Based Tumor Targeting

(2009) Stephen I. Rudnick et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

(2009) Cameron S. Brandt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular engineering and design of therapeutic antibodies

(2008) Leonard G Presta   CURRENT OPINION IN IMMUNOLOGY

Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids

(2008) M. E. Ackerman et al.   MOLECULAR CANCER THERAPEUTICS

Reprogramming of murine and human somatic cells using a single polycistronic vector

(2008) B. W. Carey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA