Antibody humanization by structure-based computational protein design

Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate

(2015) Regina S. Salvat et al.   PLoS Computational Biology

Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate

(2014) Regina S. Salvat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Computational tools for designing and engineering enzymes

(2014) Jiri Damborsky et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Highly parallel characterization of IgG Fc binding interactions

(2014) Austin W Boesch et al.   mAbs

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

(2014) E-Chiang Lee et al.   NATURE BIOTECHNOLOGY

Removing T-cell epitopes with computational protein design

(2014) C. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

(2014) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution modeling of antibody structures by a combination of bioinformatics, expert knowledge, and molecular simulations

(2014) Hiroki Shirai et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Blind prediction performance of RosettaAntibody 3.0: Grafting, relaxation, kinematic loop modeling, and full CDR optimization

(2014) Brian D. Weitzner et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Antibody structure determination using a combination of homology modeling, energy-based refinement, and loop prediction

(2014) Kai Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Antibody humanization methods – a review and update

(2013) Yaghoub Safdari et al.   Biotechnology & Genetic Engineering Reviews

Monoclonal antibody humanness score and its applications

(2013) Sean H Gao et al.   BMC BIOTECHNOLOGY

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

(2013) Vibha Jawa et al.   CLINICAL IMMUNOLOGY

De novo enzymes by computational design

(2013) Hajo Kries et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-Guided Deimmunization of Therapeutic Proteins

(2013) Andrew S. Parker et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

ABangle: characterising the VH-VL orientation in antibodies

(2013) J. Dunbar et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Fragment-based modeling of membrane protein loops: Successes, failures, and prospects for the future

(2013) Sebastian Kelm et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

An NKp30-Based Chimeric Antigen Receptor Promotes T Cell Effector Functions and Antitumor Efficacy In Vivo

(2012) T. Zhang et al.   JOURNAL OF IMMUNOLOGY

Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure

(2012) Vered Kunik et al.   NUCLEIC ACIDS RESEARCH

Protein Design Using Continuous Rotamers

(2012) Pablo Gainza et al.   PLoS Computational Biology

A novel platform to produce human monoclonal antibodies

(2011) Marcus Duvall et al.   mAbs

Predicting antibody complementarity determining region structures without classification

(2011) Yoonjoo Choi et al.   Molecular BioSystems

A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments

(2011) Lu He et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Humanness of Macaque Antibody Sequences

(2010) Philippe Thullier et al.   JOURNAL OF MOLECULAR BIOLOGY

A New Clustering of Antibody CDR Loop Conformations

(2010) Benjamin North et al.   JOURNAL OF MOLECULAR BIOLOGY

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Energy-Based Analysis and Prediction of the Orientation between Light- and Heavy-Chain Antibody Variable Domains

(2009) Arjun Narayanan et al.   JOURNAL OF MOLECULAR BIOLOGY

Finding better protein engineering strategies

(2009) Romas J Kazlauskas et al.   Nature Chemical Biology

Computational structure-based redesign of enzyme activity

(2009) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved prediction of protein side-chain conformations with SCWRL4

(2009) Georgii G. Krivov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Review: To What Extent are T Cells Tolerant to Immunoglobulin Variable Regions?

(2009) B. Bogen et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

PIGS: automatic prediction of antibody structures

(2008) P. Marcatili et al.   BIOINFORMATICS

Analysis and improvements to Kabat and structurally correct numbering of antibody variable domains

(2008) K.R. Abhinandan et al.   MOLECULAR IMMUNOLOGY

Toward high-resolution homology modeling of antibody Fvregions and application to antibody-antigen docking

(2008) Arvind Sivasubramanian et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS