Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks

(2015) Nadine R. Lang et al.   Acta Biomaterialia

Tuning the Microenvironment: Click-Crosslinked Hyaluronic Acid-Based Hydrogels Provide a Platform for Studying Breast Cancer Cell Invasion

(2015) Stephanie A. Fisher et al.   ADVANCED FUNCTIONAL MATERIALS

Cell adhesion strength from cortical tension - an integration of concepts

(2015) R. Winklbauer   JOURNAL OF CELL SCIENCE

Three-dimensional force microscopy of cells in biopolymer networks

(2015) Julian Steinwachs et al.   NATURE METHODS

Stress controls the mechanics of collagen networks

(2015) Albert James Licup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells

(2015) Vivek B. Shenoy et al.   Interface Focus

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

(2015) Stephanie I. Fraley et al.   Scientific Reports

Cell Invasion Dynamics into a Three Dimensional Extracellular Matrix Fibre Network

(2015) Min-Cheol Kim et al.   PLoS Computational Biology

Glycosaminoglycan functionalization of mechanically and topologically defined collagen I matrices

(2015) Liv Kalbitzer et al.   Journal of Materials Chemistry B

Long-Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers

(2014) Hailong Wang et al.   BIOPHYSICAL JOURNAL

Contractile forces regulate cell division in three-dimensional environments

(2014) Ayelet Lesman et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Estimating the 3D Pore Size Distribution of Biopolymer Networks from Directionally Biased Data

(2013) Nadine R. Lang et al.   BIOPHYSICAL JOURNAL

Rapid disorganization of mechanically interacting systems of mammary acini

(2013) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Modeling of Single-Cell Migration: The Leading Role of Extracellular Matrix Fibers

(2012) Daniela K. Schlüter et al.   BIOPHYSICAL JOURNAL

Strain stiffening in collagen I networks

(2012) Stéphanie Motte et al.   BIOPOLYMERS

Invasion from a cell aggregate—the roles of active cell motion and mechanical equilibrium

(2012) A Szabó et al.   PHYSICAL BIOLOGY

Adhesion Functions in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells

(2012) J.-L. Maitre et al.   SCIENCE

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Mechano-sensing and cell migration: a 3D model approach

(2011) C Borau et al.   PHYSICAL BIOLOGY

Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel

(2011) Renaud Poincloux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of the Rho-family small GTPases in actin regulation and motility

(2011) Désirée Spiering et al.   Cell Adhesion & Migration

The effect of matrix characteristics on fibroblast proliferation in 3D gels

(2010) Katrin Bott et al.   BIOMATERIALS

An Off-Lattice Hybrid Discrete-Continuum Model of Tumor Growth and Invasion

(2010) Junhwan Jeon et al.   BIOPHYSICAL JOURNAL

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

Direct Comparisons of the Morphology, Migration, Cell Adhesions, and Actin Cytoskeleton of Fibroblasts in Four Different Three-Dimensional Extracellular Matrices

(2010) Kirsi M. Hakkinen et al.   TISSUE ENGINEERING PART A

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Elastic Moduli of Collagen Gels Can Be Predicted from Two-Dimensional Confocal Microscopy

(2009) Ya-li Yang et al.   BIOPHYSICAL JOURNAL

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Random versus directionally persistent cell migration

(2009) Ryan J. Petrie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AFM indentation study of breast cancer cells

(2008) Q.S. Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration

(2008) Katharine L Sodek et al.   BMC CANCER

Mechanotransduction - a field pulling together?

(2008) C. S. Chen   JOURNAL OF CELL SCIENCE

Influence of pore size on tensile strength, permeability and porosity of hyaluronan-collagen scaffolds

(2008) Amir A. Al-Munajjed et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE