Oncolytic Viruses for Cancer Therapy: Overcoming the Obstacles

Urokinase-Type Plasminogen Activator Receptor Transcriptionally Controlled Adenoviruses Eradicate Pancreatic Tumors and Liver Metastasis in Mouse Models

(2015) Meritxell Huch et al.   NEOPLASIA

A Novel Antiangiogenic Effect for Telomerase-Specific Virotherapy through Host Immune System

(2014) Y. Ikeda et al.   JOURNAL OF IMMUNOLOGY

Hypoxia enhances the replication of oncolytic herpes simplex virus in p53- breast cancer cells

(2011) Michael Fasullo et al.   CELL CYCLE

A phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers

(2010) Jianhua Chang et al.   CANCER BIOLOGY & THERAPY

Combination effect of oncolytic adenovirus therapy and herpes simplex virus thymidine kinase/ganciclovir in hepatic carcinoma animal models

(2009) Fei-qun Zheng et al.   ACTA PHARMACOLOGICA SINICA

Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

(2009) R. C. Carlisle et al.   BLOOD

Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells

(2009) K Saito et al.   BRITISH JOURNAL OF CANCER

RNA interference-mediated knockdown of p21WAF1 enhances anti-tumor cell activity of oncolytic adenoviruses

(2009) M Shiina et al.   CANCER GENE THERAPY

Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis

(2009) J-N Zheng et al.   CANCER GENE THERAPY

Deletion of the E3-6.7K/gp19K region reduces the persistence of wild-type adenovirus in a permissive tumor model in Syrian hamsters

(2009) S Bortolanza et al.   CANCER GENE THERAPY

Armed replicating adenoviruses for cancer virotherapy

(2009) J J Cody et al.   CANCER GENE THERAPY

Concomitant use of Ad5/35 chimeric oncolytic adenovirus with TRAIL gene and taxol produces synergistic cytotoxicity in gastric cancer cells

(2009) Lin Chen et al.   CANCER LETTERS

E1B-55kD-deleted oncolytic adenovirus armed with canstatin gene yields an enhanced anti-tumor efficacy on pancreatic cancer

(2009) Xiao-Ping He et al.   CANCER LETTERS

Antitumoral Immune Response by Recruitment and Expansion of Dendritic Cells in Tumors Infected with Telomerase-Dependent Oncolytic Viruses

(2009) Edukulla Ramakrishna et al.   CANCER RESEARCH

Expression of IFN-  Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma

(2009) C. L. Willmon et al.   CANCER RESEARCH

Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses

(2009) R. Strauss et al.   CANCER RESEARCH

Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma

(2009) Jeng-Long Hsieh et al.   CANCER SCIENCE

A Novel A33 Promoter-Based Conditionally Replicative Adenovirus Suppresses Tumor Growth and Eradicates Hepatic Metastases in Human Colon Cancer Models

(2009) E. G. Cafferata et al.   CLINICAL CANCER RESEARCH

Combination of Viral Oncolysis and Tumor-Specific Immunity to Control Established Tumors

(2009) C.-M. Chuang et al.   CLINICAL CANCER RESEARCH

Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand against Pancreatic Cancer

(2009) Z. Zhang et al.   CLINICAL CANCER RESEARCH

MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells

(2009) C. Y. F. Lee et al.   CLINICAL CANCER RESEARCH

Antitumor Activity of an Oncolytic Adenoviral-CD40 Ligand (CD154) Transgene Construct in Human Breast Cancer Cells

(2009) E. M. Gomes et al.   CLINICAL CANCER RESEARCH

Ad5/3-9HIF-Δ24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment

(2009) K Guse et al.   GENE THERAPY

Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer

(2009) J R Tysome et al.   GENE THERAPY

Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity

(2009) E J Ilett et al.   GENE THERAPY

Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob

(2009) T Nishimoto et al.   GENE THERAPY

Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus

(2009) Kang Jian Zhang et al.   HUMAN GENE THERAPY

Replication-Competent Ad11p Vector (RCAd11p) Efficiently Transduces and Replicates in Hormone-Refractory Metastatic Prostate Cancer Cells

(2009) Linda Sandberg et al.   HUMAN GENE THERAPY

Chemical Modification with High Molecular Weight Polyethylene Glycol Reduces Transduction of Hepatocytes and Increases Efficacy of Intravenously Delivered Oncolytic Adenovirus

(2009) Konstantin Doronin et al.   HUMAN GENE THERAPY

CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells

(2009) Yaohe Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncolytic adenovirus mediated Survivin knockdown by RNA interference suppresses human colorectal carcinoma growth in vitro and in vivo

(2009) Wei Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

E1B 55-kDa deleted, Ad5/F35 fiber chimeric adenovirus, a potential oncolytic agent for B-lymphocytic malignancies

(2009) Guohua Wang et al.   JOURNAL OF GENE MEDICINE

A chimeric adenovirus with an Ad 3 fiber knob modification augments glioma virotherapy

(2009) Suvobroto Nandi et al.   JOURNAL OF GENE MEDICINE

Targeting the Intratumoral Dendritic Cells by the Oncolytic Adenoviral Vaccine Expressing RANTES Elicits Potent Antitumor Immunity

(2009) Natalia Lapteva et al.   JOURNAL OF IMMUNOTHERAPY

E4orf1 Limits the Oncolytic Potential of the E1B-55K Deletion Mutant Adenovirus

(2009) M. A. Thomas et al.   JOURNAL OF VIROLOGY

In Vivo Retargeting of Adenovirus Type 5 to  v 6 Integrin Results in Reduced Hepatotoxicity and Improved Tumor Uptake following Systemic Delivery

(2009) L. Coughlan et al.   JOURNAL OF VIROLOGY

Adenovirus E1B 55-Kilodalton Protein: Multiple Roles in Viral Infection and Cell Transformation

(2009) A. N. Blackford et al.   JOURNAL OF VIROLOGY

Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation

(2009) J. Jin et al.   MOLECULAR CANCER THERAPEUTICS

Telomerase-specific virotherapy in an animal model of human head and neck cancer

(2009) O. Nakajima et al.   MOLECULAR CANCER THERAPEUTICS

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

(2009) B. Zheng et al.   MOLECULAR CANCER THERAPEUTICS

Attraction and Activation of Dendritic Cells at the Site of Tumor Elicits Potent Antitumor Immunity

(2009) Natalia Lapteva et al.   MOLECULAR THERAPY

Enhancement of Oncolytic Properties of Recombinant Newcastle Disease Virus Through Antagonism of Cellular Innate Immune Responses

(2009) Dmitriy Zamarin et al.   MOLECULAR THERAPY

Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian Hamsters

(2009) Sergia Bortolanza et al.   MOLECULAR THERAPY

Pre-existing Immunity and Passive Immunity to Adenovirus 5 Prevents Toxicity Caused by an Oncolytic Adenovirus Vector in the Syrian Hamster Model

(2009) Debanjan Dhar et al.   MOLECULAR THERAPY

Expanded Anticancer Therapeutic Window of Hexon-modified Oncolytic Adenovirus

(2009) Elena V Shashkova et al.   MOLECULAR THERAPY

p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication

(2009) E. Gurlevik et al.   NUCLEIC ACIDS RESEARCH

Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus

(2009) Yonatan Y. Mahller et al.   PLoS One

Tumor Associated Stromal Cells Play a Critical Role on the Outcome of the Oncolytic Efficacy of Conditionally Replicative Adenoviruses

(2009) M. Verónica Lopez et al.   PLoS One

Utilizing Ras Signaling Pathway to Direct Selective Replication of Herpes Simplex Virus-1

(2009) Weihong Pan et al.   PLoS One

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy

(2009) A. Frentzen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of multiple cell survival proteins in head and neck cancer cells by an apoptogenic mutant of adenovirus type 5

(2009) S. Vijayalingam et al.   VIROLOGY

Characterization of human adenovirus serotypes 5, 6, 11, and 35 as anticancer agents

(2009) Elena V. Shashkova et al.   VIROLOGY

Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells

(2009) Ryan Cawood et al.   PLoS Pathogens

An oncolytic adenovirus expressing granulocyte macrophage colony-stimulating factor shows improved specificity and efficacy for treating human solid tumors

(2008) N Lei et al.   CANCER GENE THERAPY

Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter

(2008) M Ahn et al.   CANCER GENE THERAPY

Conditionally replicating E1B-deleted adenovirus driven by the squamous cell carcinoma antigen 2 promoter for uterine cervical cancer therapy

(2008) K-F Hsu et al.   CANCER GENE THERAPY

E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer

(2008) K Fukuda et al.   CANCER GENE THERAPY

Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity

(2008) Y Piao et al.   CANCER GENE THERAPY

Therapy of head and neck squamous cell carcinoma with replicative adenovirus expressing tissue inhibitor of metalloproteinase-2 and chemoradiation

(2008) L R McNally et al.   CANCER GENE THERAPY

Enhanced oncolytic potency of vesicular stomatitis virus through vector-mediated inhibition of NK and NKT cells

(2008) J Altomonte et al.   CANCER GENE THERAPY

Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA

(2008) J-N Zheng et al.   CANCER GENE THERAPY

Combination therapy with radiation or cisplatin enhances the potency of Ad5/35 chimeric oncolytic adenovirus in a preclinical model of head and neck cancer

(2008) S Ganesh et al.   CANCER GENE THERAPY

JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase

(2008) W Hu et al.   CANCER GENE THERAPY

Tissue Inhibitor of Metalloproteinase-3 via Oncolytic Herpesvirus Inhibits Tumor Growth and Vascular Progenitors

(2008) Y. Y. Mahller et al.   CANCER RESEARCH

Macrophage Depletion Combined with Anticoagulant Therapy Increases Therapeutic Window of Systemic Treatment with Oncolytic Adenovirus

(2008) E. V. Shashkova et al.   CANCER RESEARCH

Cancer Cell Death Enhances the Penetration and Efficacy of Oncolytic Herpes Simplex Virus in Tumors

(2008) S. Nagano et al.   CANCER RESEARCH

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Treatment of Radioresistant Stem-Like Esophageal Cancer Cells by an Apoptotic Gene-Armed, Telomerase-Specific Oncolytic Adenovirus

(2008) X. Zhang et al.   CLINICAL CANCER RESEARCH

Treatment of Cancer with a Novel Dual-Targeted Conditionally Replicative Adenovirus Armed with mda-7/IL-24 Gene

(2008) J. Luo et al.   CLINICAL CANCER RESEARCH

Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following Intravenous Delivery of Reovirus

(2008) J. Qiao et al.   CLINICAL CANCER RESEARCH

Intratumoral Coadministration of Hyaluronidase Enzyme and Oncolytic Adenoviruses Enhances Virus Potency in Metastatic Tumor Models

(2008) S. Ganesh et al.   CLINICAL CANCER RESEARCH

E2F Promoter-Regulated Oncolytic Adenovirus with p16 Gene Induces Cell Apoptosis and Exerts Antitumor Effect on Gastric Cancer

(2008) J. Ma et al.   DIGESTIVE DISEASES AND SCIENCES

Oncolytic adenovirus-mediated shRNA against Apollon inhibits tumor cell growth and enhances antitumor effect of 5-fluorouracil

(2008) L Chu et al.   GENE THERAPY

A strategy for systemic delivery of the oncolytic herpes virus HSV1716: redirected tropism by antibody-binding sites incorporated on the virion surface as a glycoprotein D fusion protein

(2008) J Conner et al.   GENE THERAPY

Factors influencing retention of adenovirus within tumours following direct intratumoural injection

(2008) M Bazan-Peregrino et al.   GENE THERAPY

Short hairpin RNA-expressing oncolytic adenovirus-mediated inhibition of IL-8: effects on antiangiogenesis and tumor growth inhibition

(2008) J Y Yoo et al.   GENE THERAPY

Extended release of adenovirus from silica implants in vitro and in vivo

(2008) L Kangasniemi et al.   GENE THERAPY

Cell carriers to deliver oncolytic viruses to sites of myeloma tumor growth

(2008) A Munguia et al.   GENE THERAPY

A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients

(2008) J-L Li et al.   GENE THERAPY

Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus

(2008) J Foloppe et al.   GENE THERAPY

Human Telomerase Reverse Transcriptase Promoter-Driven Oncolytic Adenovirus with E1B-19 kDa and E1B-55 kDa Gene Deletions

(2008) Joshua C. Doloff et al.   HUMAN GENE THERAPY

Effect of Preexisting Immunity on Oncolytic Adenovirus Vector INGN 007 Antitumor Efficacy in Immunocompetent and Immunosuppressed Syrian Hamsters

(2008) D. Dhar et al.   JOURNAL OF VIROLOGY

Tumor Antigen LRRC15 Impedes Adenoviral Infection: Implications for Virus-Based Cancer Therapy

(2008) J. O'Prey et al.   JOURNAL OF VIROLOGY

Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B

(2008) B. P. McSharry et al.   JOURNAL OF VIROLOGY

Generation of a Conditionally Replicating Adenovirus Based on Targeted Destruction of E1A mRNA by a Cell Type-Specific MicroRNA

(2008) E. Ylosmaki et al.   JOURNAL OF VIROLOGY

Adenovirus E1B55K Region Is Required To Enhance Cyclin E Expression for Efficient Viral DNA Replication

(2008) X. Zheng et al.   JOURNAL OF VIROLOGY

Gene-Viral Cancer Therapy Using Dual-Regulated Oncolytic Adenovirus with Antiangiogenesis Gene for Increased Efficacy

(2008) C. Su et al.   MOLECULAR CANCER RESEARCH

Identification of a novel blocker of I B  kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor- B

(2008) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS

A novel triple-regulated oncolytic adenovirus carrying p53 gene exerts potent antitumor efficacy on common human solid cancers

(2008) Xinghua Wang et al.   MOLECULAR CANCER THERAPEUTICS

Novel Cancer Antiangiotherapy Using the VEGF Promoter-targeted Artificial Zinc-finger Protein and Oncolytic Adenovirus

(2008) Yoon-A Kang et al.   MOLECULAR THERAPY

Interleukin-13 Displaying Retargeted Oncolytic Measles Virus Strains Have Significant Activity Against Gliomas With Improved Specificity

(2008) Cory Allen et al.   MOLECULAR THERAPY

Oncolytic HSV-1 Infection of Tumors Induces Angiogenesis and Upregulates CYR61

(2008) Kazuhiko Kurozumi et al.   MOLECULAR THERAPY

Trichostatin A and Oncolytic HSV Combination Therapy Shows Enhanced Antitumoral and Antiangiogenic Effects

(2008) Ta-Chiang Liu et al.   MOLECULAR THERAPY

Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model

(2008) Maria A Thomas et al.   MOLECULAR THERAPY

A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication

(2008) Robert E Edge et al.   MOLECULAR THERAPY

Hypoxia Enhances the Replication of Oncolytic Herpes Simplex Virus

(2008) Manish K Aghi et al.   MOLECULAR THERAPY

Engineering microRNA responsiveness to decrease virus pathogenicity

(2008) Elizabeth J Kelly et al.   NATURE MEDICINE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Mesenchymal Stem Cells Effectively Deliver an Oncolytic Adenovirus to Intracranial Glioma

(2008) Adam M. Sonabend et al.   STEM CELLS

Virotherapy of Ovarian Cancer With Polymer-cloaked Adenovirus Retargeted to the Epidermal Growth Factor Receptor

(2007) Joanne Morrison et al.   MOLECULAR THERAPY