The architecture of a eukaryotic replisome

Reconsidering DNA Polymerases at the Replication Fork in Eukaryotes

(2015) Bruce Stillman   MOLECULAR CELL

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

(2015) Robert E. Johnson et al.   MOLECULAR CELL

Structure of the eukaryotic MCM complex at 3.8 Å

(2015) Ningning Li et al.   NATURE

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

(2015) Anders R Clausen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement

(2015) Tatjana Petojevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

(2015) Anders R Clausen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

(2015) Roxana E Georgescu et al.   eLife

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

(2014) Jingchuan Sun et al.   GENES & DEVELOPMENT

DNA polymerase ε and its roles in genome stability

(2014) Erin E. Henninger et al.   IUBMB LIFE

Structural Characterization by Cross-linking Reveals the Detailed Architecture of a Coatomer-related Heptameric Module from the Nuclear Pore Complex

(2014) Yi Shi et al.   MOLECULAR & CELLULAR PROTEOMICS

Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

(2014) Chuanhe Yu et al.   MOLECULAR CELL

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

(2014) Aline C. Simon et al.   NATURE

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit

(2014) Murat A Cevher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork

(2014) Roxana E Georgescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain

(2014) Rinku Jain et al.   PLoS One

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dpb2 Integrates the Leading-Strand DNA Polymerase into the Eukaryotic Replisome

(2013) Sugopa Sengupta et al.   CURRENT BIOLOGY

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase

(2013) Y.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya

(2013) M. O'Donnell et al.   Cold Spring Harbor Perspectives in Biology

The Minichromosome Maintenance Replicative Helicase

(2013) S. D. Bell et al.   Cold Spring Harbor Perspectives in Biology

Replicative DNA Polymerases

(2013) E. Johansson et al.   Cold Spring Harbor Perspectives in Biology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Expanding the Chemical Cross-Linking Toolbox by the Use of Multiple Proteases and Enrichment by Size Exclusion Chromatography

(2012) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

Bypass of a protein barrier by a replicative DNA helicase

(2012) Hasan Yardimci et al.   NATURE

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

(2011) Izumi Miyabe et al.   PLoS Genetics

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases

(2009) Sebastian Klinge et al.   EMBO JOURNAL

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase Dynamics at the Eukaryotic DNA Replication Fork

(2008) Peter M. J. Burgers   JOURNAL OF BIOLOGICAL CHEMISTRY

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

Dividing the workload at a eukaryotic replication fork

(2008) Thomas A. Kunkel et al.   TRENDS IN CELL BIOLOGY