The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

(2015) Charles K. Pallangyo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

(2015) Vasiliki Koliaraki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

I B  Is a Key Regulator of B Cell Expansion by Providing Negative Feedback on cRel and RelA in a Stimulus-Specific Manner

(2014) B. N. Alves et al.   JOURNAL OF IMMUNOLOGY

PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis

(2014) Shuang Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inflammatory bowel disease: Pathogenesis

(2014) Yi-Zhen Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy

(2013) Shuxian Dong et al.   Cell Metabolism

A20-mediated negative regulation of canonical NF-κB signaling pathway

(2013) Rajeshree Pujari et al.   IMMUNOLOGIC RESEARCH

REG  deficiency promotes premature aging via the casein kinase 1 pathway

(2013) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REGγ is associated with multiple oncogenic pathways in human cancers

(2012) Jing He et al.   BMC CANCER

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates dextran sulfate sodium-induced colitis in mice

(2011) Zhi Jing Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

(2011) Katerina Vlantis et al.   JOURNAL OF CLINICAL INVESTIGATION

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits

(2011) Daniel Wong et al.   GENOME BIOLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

REGγ modulates p53 activity by regulating its cellular localization

(2010) Jian Liu et al.   JOURNAL OF CELL SCIENCE

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex

(2010) Cristina Aguilera et al.   NATURE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Regulatory Logic of the NF- B Signaling System

(2009) E. O'Dea et al.   Cold Spring Harbor Perspectives in Biology

REGγ, a proteasome activator and beyond?

(2008) I. Mao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NF-κB dictates the degradation pathway of IκBα

(2008) Erika Mathes et al.   EMBO JOURNAL

Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis

(2008) A. Lubbad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

UV as an Amplifier Rather Than Inducer of NF-κB Activity

(2008) Ellen L. O'Dea et al.   MOLECULAR CELL

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE