Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme

Genotypic Complexity of Fisher’s Geometric Model

(2017) Sungmin Hwang et al.   GENETICS

Mistranslation can enhance fitness through purging of deleterious mutations

(2017) Sinisa Bratulic et al.   Nature Communications

Genotypic Complexity of Fisher’s Geometric Model

(2017) Sungmin Hwang et al.   GENETICS

Tempo and mode of genome evolution in a 50,000-generation experiment

(2016) Olivier Tenaillon et al.   NATURE

Divergent evolution peaks under intermediate population bottlenecks during bacterial experimental evolution

(2016) Tom Vogwill et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

How mutational epistasis impairs predictability in protein evolution and design

(2016) Charlotte M. Miton et al.   PROTEIN SCIENCE

Competition along trajectories governs adaptation rates towards antimicrobial resistance

(2016) C. Brandon Ogbunugafor et al.   Nature Ecology & Evolution

The competition between simple and complex evolutionary trajectories in asexual populations

(2015) Ian E Ochs et al.   BMC EVOLUTIONARY BIOLOGY

Evolvability as a Function of Purifying Selection in TEM-1 β-Lactamase

(2015) Michael A. Stiffler et al.   CELL

Indirect resistance to several classes of antibiotics in cocultures with resistant bacteria expressing antibiotic-modifying or -degrading enzymes

(2015) Hervé Nicoloff et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Methods for the directed evolution of proteins

(2015) Michael S. Packer et al.   NATURE REVIEWS GENETICS

A tortoise–hare pattern seen in adapting structured and unstructured populations suggests a rugged fitness landscape in bacteria

(2015) Joshua R. Nahum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

(2015) Shrenik C. Mehta et al.   PLoS Pathogens

Role of pleiotropy during adaptation of TEM-1β-lactamase to two novel antibiotics

(2014) Martijn F. Schenk et al.   Evolutionary Applications

Dynamics and constraints of enzyme evolution

(2014) Miriam Kaltenbach et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Empirical fitness landscapes and the predictability of evolution

(2014) J. Arjan G.M. de Visser et al.   NATURE REVIEWS GENETICS

Should evolutionary geneticists worry about higher-order epistasis?

(2013) Daniel M Weinreich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene

(2013) Martijn F. Schenk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Bacterial cheating drives the population dynamics of cooperative antibiotic resistance plasmids

(2013) Eugene A Yurtsev et al.   Molecular Systems Biology

Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution

(2013) B. C. Dickinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

POPULATION SUBDIVISION AND ADAPTATION IN ASEXUAL POPULATIONS OF SACCHAROMYCES CEREVISIAE

(2012) Sergey Kryazhimskiy et al.   EVOLUTION

Deep Sequencing of Systematic Combinatorial Libraries Reveals β-Lactamase Sequence Constraints at High Resolution

(2012) Zhifeng Deng et al.   JOURNAL OF MOLECULAR BIOLOGY

Predictability of evolution depends nonmonotonically on population size

(2012) I. G. Szendro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the Adaptive Potential of an Antibiotic Resistance Enzyme

(2012) Martijn F. Schenk et al.   PLoS Genetics

EVOLUTIONARY ADVANTAGE OF SMALL POPULATIONS ON COMPLEX FITNESS LANDSCAPES

(2011) Kavita Jain et al.   EVOLUTION

Second-Order Selection for Evolvability in a Large Escherichia coli Population

(2011) R. J. Woods et al.   SCIENCE

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

GENOME STRUCTURE AND THE BENEFIT OF SEX

(2010) Richard A. Watson et al.   EVOLUTION

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes

(2009) Andreas Handel et al.   BMC EVOLUTIONARY BIOLOGY

Increased Folding Stability of TEM-1 β-Lactamase by In Vitro Selection

(2008) Insa Kather et al.   JOURNAL OF MOLECULAR BIOLOGY

Intense Neutral Drifts Yield Robust and Evolvable Consensus Proteins

(2008) Shimon Bershtein et al.   JOURNAL OF MOLECULAR BIOLOGY

Heterogeneous Adaptive Trajectories of Small Populations on Complex Fitness Landscapes

(2008) Daniel E. Rozen et al.   PLoS One

Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli

(2008) Z. D. Blount et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA