Granulocyte-colony–stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

(2017) Ming-Chin Lee et al.   JOURNAL OF IMMUNOLOGY

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

(2017) John A. Hamilton et al.   NATURE REVIEWS DRUG DISCOVERY

Immune Regulation of Antibody Access to Neuronal Tissues

(2017) Akiko Iwasaki   TRENDS IN MOLECULAR MEDICINE

Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis

(2016) Elizabeth A. Mazzio et al.   BMC Complementary and Alternative Medicine

Chronic peripheral inflammation, hippocampal neurogenesis, and behavior

(2016) Vera Chesnokova et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia in health and pain: impact of noxious early life events

(2016) Nikita N. Burke et al.   EXPERIMENTAL PHYSIOLOGY

Neuron-immune mechanisms contribute to pain in early stages of arthritis

(2016) Francisco R. Nieto et al.   Journal of Neuroinflammation

Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation

(2016) Alexis Bavencoffe et al.   JOURNAL OF NEUROSCIENCE

Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability

(2016) Tiphaine Voisin et al.   JOURNAL OF PHYSIOLOGY-LONDON

The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel

(2016) Mircea Iftinca et al.   Molecular Pain

Hippocampal microglial activation and glucocorticoid receptor down-regulation precipitate visceral hypersensitivity induced by colorectal distension in rats

(2016) Gongliang Zhang et al.   NEUROPHARMACOLOGY

Microglia and chronic pain

(2016) Marzia Malcangio   PAIN

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction

(2016) Xia Hu et al.   Cell Reports

Reversible Induction of Pain Hypersensitivity following Optogenetic Stimulation of Spinal Astrocytes

(2016) Youngpyo Nam et al.   Cell Reports

Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats

(2016) Masamichi Okubo et al.   PLoS One

TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis

(2015) Tamia K. Lapointe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal inflammation and pain management

(2015) Lilian Basso et al.   CURRENT OPINION IN PHARMACOLOGY

Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10

(2015) Thacyana T. Carvalho et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic intestinal inflammation alters hippocampal neurogenesis

(2015) Svetlana Zonis et al.   Journal of Neuroinflammation

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

(2015) Zhonghui Guan et al.   NATURE NEUROSCIENCE

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

Analgesic effect of minocycline in rat model of inflammation-induced visceral pain

(2014) Pradeep Kannampalli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity

(2014) Annemie Deiteren et al.   GUT

Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced Hypersensitivity

(2014) Robyn Flynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Descending Controls Modulate Inflammatory Joint Pain and Regulate CXC Chemokine and iNOS Expression in the Dorsal Horn

(2014) Fiona B Carr et al.   Molecular Pain

Neuroplasticity and dysfunction after gastrointestinal inflammation

(2014) Stuart M. Brierley et al.   Nature Reviews Gastroenterology & Hepatology

Calcium-Permeable Ion Channels in Pain Signaling

(2014) Emmanuel Bourinet et al.   PHYSIOLOGICAL REVIEWS

Endogenous Regulation of Visceral Pain via Production of Opioids by Colitogenic CD4+ T Cells in Mice

(2013) Jérôme Boué et al.   GASTROENTEROLOGY

A Systematic Review of the Evidence for Central Nervous System Plasticity in Animal Models of Inflammatory-mediated Gastrointestinal Pain

(2013) Kristen E. Farrell et al.   INFLAMMATORY BOWEL DISEASES

Transcriptional Mechanisms Underlying Sensitization of Peripheral Sensory Neurons by Granulocyte-/Granulocyte-Macrophage Colony Stimulating Factors

(2013) Kiran Kumar Bali et al.   Molecular Pain

Intrathecal granulocyte colony-stimulating factor modulate glial cell line-derived neurotrophic factor and vascular endothelial growth factor A expression in glial cells after experimental spinal cord ischemia

(2013) C.-H. Chen et al.   NEUROSCIENCE

Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury

(2013) Y. Guo et al.   NEUROSCIENCE

P2X4R+ microglia drive neuropathic pain

(2012) Simon Beggs et al.   NATURE NEUROSCIENCE

Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model

(2011) Anna K. Clark et al.   ARTHRITIS AND RHEUMATISM

Chemokine mediated neuron–glia communication and aberrant signalling in neuropathic pain states

(2011) Elizabeth Amy Old et al.   CURRENT OPINION IN PHARMACOLOGY

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-Dependent Mechanism in Mice

(2011) Fiore Cattaruzza et al.   GASTROENTEROLOGY

Spinal Microglia Initiate and Maintain Hyperalgesia in a Rat Model of Chronic Pancreatitis

(2011) Pei–Yi Liu et al.   GASTROENTEROLOGY

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

(2011) S. Heine et al.   JOURNAL OF NEUROSCIENCE

Monocyte Chemoattractant Protein-1-Deficiency Impairs the Expression of IL-6, IL-1β and G-CSF after Transient Focal Ischemia in Mice

(2011) Jan-Kolja Strecker et al.   PLoS One

Editorial: Inflammatory Bowel Disease, Irritable Bowel Syndrome, or What?: A Challenge to the Functional–Organic Dichotomy

(2010) Millie D Long et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel-Like Syndrome

(2010) Simona Agostini et al.   GASTROENTEROLOGY

What is this thing called pain?

(2010) Clifford J. Woolf   JOURNAL OF CLINICAL INVESTIGATION

Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice

(2010) Ryo Yamasaki et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways

(2010) Caterina Veroni et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF

(2009) Jing Ding et al.   BRAIN BEHAVIOR AND IMMUNITY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Spinal cord long-term potentiation (LTP) is associated with increased dorsal horn gene expression of IL-1β, GDNF and iNOS

(2009) Linda M. Pedersen et al.   EUROPEAN JOURNAL OF PAIN

The Liberation of Fractalkine in the Dorsal Horn Requires Microglial Cathepsin S

(2009) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Hematopoietic colony–stimulating factors mediate tumor-nerve interactions and bone cancer pain

(2009) Matthias Schweizerhof et al.   NATURE MEDICINE

Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress

(2008) Sylvie Bradesi et al.   GASTROENTEROLOGY

Is chronic pain an extraintestinal manifestation of IBD?

(2008) Corey A. Siegel et al.   INFLAMMATORY BOWEL DISEASES

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis

(2007) QiQi Zhou et al.   PAIN

Transition from acute to chronic pain and disability: A model including cognitive, affective, and trauma factors

(2007) Corinna Young Casey et al.   PAIN