Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits

Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077

(2017) Annabel Romero-Hernandez et al.   MOLECULAR PHARMACOLOGY

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

(2017) Weinan Sun et al.   NEURON

Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain

(2016) Lucia Tamborini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors

(2016) Feng Yi et al.   NEURON

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

(2016) David H. Hackos et al.   NEURON

MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit

(2016) Robert A. Volkmann et al.   PLoS One

NMDA receptor modulators: an updated patent review (2013 – 2014)

(2014) Katie L Strong et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABAAreceptors

(2014) Marcel P. Goldschen-Ohm et al.   JOURNAL OF GENERAL PHYSIOLOGY

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Structural Insights into Competitive Antagonism in NMDA Receptors

(2014) Annie Jespersen et al.   NEURON

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Crystal Structure and Pharmacological Characterization of a NovelN-Methyl-d-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site

(2013) Trine Kvist et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

(2012) Daniel T. Monaghan et al.   NEUROCHEMISTRY INTERNATIONAL

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

(2012) Eva Chovancova et al.   PLoS Computational Biology

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors

(2011) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

Molecular pharmacology of human NMDA receptors

(2011) Maiken Hedegaard et al.   NEUROCHEMISTRY INTERNATIONAL

New advances in NMDA receptor pharmacology

(2011) Kevin K. Ogden et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Novel 3-Carboxy- and 3-Phosphonopyrazoline Amino Acids as Potent and Selective NMDA Receptor Antagonists: Design, Synthesis, and Pharmacological Characterization

(2010) Paola Conti et al.   ChemMedChem

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the MajorN-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

(2010) Claudia Rauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Family of Negative and Positive Allosteric Modulators of NMDA Receptors

(2010) B. M. Costa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain

(2009) H. Yuan et al.   JOURNAL OF NEUROSCIENCE

N-Methyl-D-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse

(2009) B. M. Costa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B

(2009) Zhenyu Sheng et al.   NEUROPHARMACOLOGY

Taking The Time To Study Competitive Antagonism

(2007) D J A Wyllie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia

(2007) Jeffrey A. Pfefferkorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed inXenopus laevisoocytes

(2007) Philip E. Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON