Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions

Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised controlled trial

(2013) Heart Protection Study Collaborative Group   LANCET

Computational approaches to disease-gene prediction: rationale, classification and successes

(2012) Rosario M. Piro et al.   FEBS Journal

Race, ethnicity, and the efficacy of rosuvastatin in primary prevention: The Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial

(2011) Michelle A. Albert et al.   AMERICAN HEART JOURNAL

Cardiovascular Pharmacogenomics

(2011) Dan M. Roden et al.   CIRCULATION RESEARCH

The Impact of Pharmacogenomics on the Management of Cardiac Disease

(2011) N L Pereira et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network

(2011) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Emerging Role of Electronic Medical Records in Pharmacogenomics

(2011) R A Wilke et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Statin-induced myopathy: a review and update

(2011) Thura T Abd et al.   Expert Opinion On Drug Safety

Genetics and Variable Drug Response

(2011) Russell A. Wilke et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and tolerability of once-weekly rosuvastatin in patients with previous statin intolerance

(2011) Steven P. Kennedy et al.   Journal of Clinical Lipidology

Statins and safety: can we finally be reassured?

(2011) Payal Kohli et al.   LANCET

Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: Evidence for additional functions of EYS

(2011) Paul J. Isackson et al.   MUSCLE & NERVE

Weighing the Benefits of High-Dose Simvastatin against the Risk of Myopathy

(2011) Amy Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cerivastatin, genetic variants, and the risk of rhabdomyolysis

(2011) Kristin D. Marciante et al.   Pharmacogenetics and Genomics

Integrative genomics strategies to elucidate the complexity of drug response

(2011) Andrew Kasarskis et al.   PHARMACOGENOMICS

Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children

(2011) Tesfaye M. Baye et al.   PLoS One

Impact ofSLCO1B1(OATP1B1) andABCG2(BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins

(2011) Grant T. Generaux et al.   XENOBIOTICA

Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

(2011) Guillaume Lettre et al.   PLoS Genetics

Prioritizing GWAS Results: A Review of Statistical Methods and Recommendations for Their Application

(2010) Rita M. Cantor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Combined Influence of LDLR and HMGCR Sequence Variation on Lipid-Lowering Response to Simvastatin

(2010) Lara M. Mangravite et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic involvement in statins induced myopathy. Preliminary data from an observational case–control study

(2010) Luca Puccetti et al.   ATHEROSCLEROSIS

Pitavastatin

(2010) Haniyyah Ahmad et al.   Cardiology in Review

Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study

(2010) L A Donnelly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ABCG2 Polymorphism Is Associated With the Low-Density Lipoprotein Cholesterol Response to Rosuvastatin

(2010) B Tomlinson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The effects of statins on skeletal muscle strength and exercise performance

(2010) Guru M Krishnan et al.   CURRENT OPINION IN LIPIDOLOGY

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

Statistical analysis strategies for association studies involving rare variants

(2010) Vikas Bansal et al.   NATURE REVIEWS GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis

(2010) Rüdiger Kaspera et al.   Pharmacogenetics and Genomics

Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins

(2010) Kuo-Liong Chien et al.   PHARMACOGENOMICS

Mapping genes that predict treatment outcome in admixed populations

(2010) T M Baye et al.   PHARMACOGENOMICS JOURNAL

UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

(2009) S Riedmaier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin

(2009) J E Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Using biological networks to search for interacting loci in genome-wide association studies

(2009) Mathieu Emily et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Possible Mechanisms Underlying Statin-Induced Skeletal Muscle Toxicity in L6 Fibroblasts and in Rats

(2009) Mai Itagaki et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The HMG-CoA Reductase Gene and Lipid and Lipoprotein Levels: the Multi-Ethnic Study of Atherosclerosis

(2009) Yi-Chun Chen et al.   LIPIDS

Muscle toxicity with statins

(2009) Karin Hedenmalm et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Rhabdomyolysis reports show interaction between simvastatin and CYP3A4 inhibitors

(2009) Christopher Rowan et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Different effects of theABCG2c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin

(2009) Jenni E Keskitalo et al.   PHARMACOGENOMICS

Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy

(2009) Tomomi Furihata et al.   PHARMACOGENOMICS JOURNAL

Pharmacogenomic insights into treatment and management of statin-induced myopathy

(2009) Bas JM Peters et al.   Genome Medicine

Database mining for selection of SNP markers useful in admixture mapping

(2009) Tesfaye M Baye et al.   BioData Mining

ABCG2: A perspective

(2008) Robert W. Robey et al.   ADVANCED DRUG DELIVERY REVIEWS

Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER

(2008) Eliana Polisecki et al.   ATHEROSCLEROSIS

Antiretroviral and Statin Drug-Drug Interactions

(2008) Gretchen M. Ray   Cardiology in Review

Variation in the 3-Hydroxyl-3-Methylglutaryl Coenzyme A Reductase Gene Is Associated With Racial Differences in Low-Density Lipoprotein Cholesterol Response to Simvastatin Treatment

(2008) Ronald M. Krauss et al.   CIRCULATION

Alternative Splicing of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Is Associated With Plasma Low-Density Lipoprotein Cholesterol Response to Simvastatin

(2008) Marisa Wong Medina et al.   CIRCULATION

Pharmacokinetic Comparison of the Potential Over-the-Counter Statins Simvastatin, Lovastatin, Fluvastatin and Pravastatin

(2008) Pertti J Neuvonen et al.   CLINICAL PHARMACOKINETICS

Genome-wide association studies: potential next steps on a genetic journey

(2008) M. I. McCarthy et al.   HUMAN MOLECULAR GENETICS

Opportunities for Enhancing the FDA Guidance on Pharmacovigilance

(2008) Bruce M. Psaty   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide analysis of transcript isoform variation in humans

(2008) Tony Kwan et al.   NATURE GENETICS

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

The safety of rosuvastatin in comparison with other statins in over 100 000 statin users in UK primary care

(2008) Luis Alberto García-Rodríguez et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

A paucimorphic variant in the HMG-CoA reductase gene is associated with lipid-lowering response to statin treatment in diabetes: a GoDARTS study

(2008) Louise A. Donnelly et al.   Pharmacogenetics and Genomics

Pharmacogenetic Testing for Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphisms: Are We There Yet?

(2008) Minoli A Perera et al.   PHARMACOTHERAPY

Statin Induced Myopathy and Myalgia: Time Trend Analysis and Comparison of Risk Associated with Statin Class from 1991–2006

(2008) Mariam Molokhia et al.   PLoS One