Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity

Uncoupling lifespan and healthspan inCaenorhabditis eleganslongevity mutants

(2015) Ankita Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caenorhabditis elegans as a Model System for Studying Drug Induced Mitochondrial Toxicity

(2015) Richard de Boer et al.   PLoS One

Zidovudine Induces Downregulation of Mitochondrial Deoxynucleoside Kinases: Implications for Mitochondrial Toxicity of Antiviral Nucleoside Analogs

(2014) Ren Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome System

(2014) Alexandra Segref et al.   Cell Metabolism

The paradox of mitochondrial dysfunction and extended longevity

(2014) Erin Munkácsy et al.   EXPERIMENTAL GERONTOLOGY

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

(2014) Michael Ristow   NATURE MEDICINE

CEP-1, the Caenorhabditis elegans p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants

(2014) Aiswarya Baruah et al.   PLoS Genetics

Nucleoside Reverse Transcriptase Inhibitors Induce a Mitophagy-Associated Endothelial Cytotoxicity That Is Reversed by Coenzyme Q10 Cotreatment

(2013) Stephen Y. Xue et al.   TOXICOLOGICAL SCIENCES

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Mitochondrial Dysfunction in Aging and Longevity: A Causal or Protective Role?

(2012) Daniel A. Pulliam et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Stress and Mitochondrial Impairment After Treatment with Anti-HIV Drugs: Clinical Implications

(2012) Ana Blas-Garcia et al.   CURRENT PHARMACEUTICAL DESIGN

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

ROS in AgingCaenorhabditis elegans: Damage or Signaling?

(2012) Patricia Back et al.   Oxidative Medicine and Cellular Longevity

In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

(2012) Kyle R. Hukezalie et al.   PLoS One

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Kinetic Effects on Thymidine Kinase 2 by Enzyme-Bound dTTP May Explain the Mitochondrial Side Effects of Antiviral Thymidine Analogs

(2011) Liya Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Toxicity in HAART: An Overview of In Vitro Evidence

(2011) Nadezda Apostolova et al.   CURRENT PHARMACEUTICAL DESIGN

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition

(2011) Nadezda Apostolova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Effect of Antioxidants on Mitochondrial Function in HIV-1–Related Lipoatrophy: A Pilot Study

(2010) Laura Milazzo et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial cells

(2010) Kalyan Reddy Manda et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Optimal micronutrients delay mitochondrial decay and age-associated diseases

(2010) Bruce N. Ames   MECHANISMS OF AGEING AND DEVELOPMENT

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

(2010) Andrew R Burns et al.   Nature Chemical Biology

Trans-Cellular Introduction of HIV-1 Protein Nef Induces Pathogenic Response in Caenorhabditis elegans

(2010) Aamir Nazir et al.   PLoS One

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Condition-adapted stress and longevity gene regulation byCaenorhabditis elegansSKN-1/Nrf

(2009) Riva P. Oliveira et al.   AGING CELL

Roles and Mechanisms of Human Immunodeficiency Virus Protease Inhibitor Ritonavir and Other Anti-Human Immunodeficiency Virus Drugs in Endothelial Dysfunction of Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells

(2009) Xinwen Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors

(2009) M. V. Stankov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

(2009) Tomas Cihlar et al.   ANTIVIRAL RESEARCH

C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles

(2009) Eyleen J. O'Rourke et al.   Cell Metabolism

Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy

(2009) Antonella Mandas et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mitochondrial DNA level, but not active replicase, is essential for Caenorhabditis elegans development

(2009) Ivana Bratic et al.   NUCLEIC ACIDS RESEARCH

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

The mitochondrial cocktail: Rationale for combined nutraceutical therapy in mitochondrial cytopathies☆

(2008) M.A. Tarnopolsky   ADVANCED DRUG DELIVERY REVIEWS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction

(2008) Erik R. Kline et al.   Cardiovascular Toxicology

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Hormesis defined

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS

Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors

(2007) Kaleb C. Lund et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY