Article
Multidisciplinary Sciences
Sandra Bajana, Aneta Pankow, Kaili Liu, Martyna Michniowska, Joseph F. Urban, Wei R. Chen, Xiao-Hong Sun
Summary: The thymus plays a role in maintaining the homeostasis of ILC pools in tissues, especially in the absence of E protein transcription factors. ILC precursors can differentiate into various subsets in vitro, and in steady state, icCD3 epsilon(+) cells differentiate into diverse ILC subsets in different tissue environments. Helminth infection promotes their differentiation into functional ILC2s. This finding may help explain age-related differences in immune responses, as thymic activity is age-dependent.
Review
Pharmacology & Pharmacy
Chengyuan Zhang, Xuemei Zhou, Hanyi Zhang, Xuanliang Han, Baijun Li, Ran Yang, Xing Zhou
Summary: Multidrug resistance (MDR) is a major reason for chemotherapy failure, and developing nano-delivery systems for MDR tumors has become important. This review systematically summarizes recent advances in nanotechnology targeting different mechanisms of MDR. However, there are still issues with nano-delivery systems for MDR tumors, such as excessive use of carrier materials, low drug-loading capacity, and limited targeting mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ian G. Chambers, Praveen Kumar, Jens Lichtenberg, Pengcheng Wang, Jianshi Yu, John D. Phillips, Maureen A. Kane, David Bodine, Iqbal Hamza
Summary: MRP5 and MRP9 transporters play a coordinated role in regulating male reproductive functions and mitochondrial sufficiency in mice. The absence of MRP5 leads to significant male reproductive deficits.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Polymer Science
Yi Qin, Weipan Peng, Xiaoqun Gong, Dianming Zhou, Wenna Li, Minghui Chen, Guowei Lian, Jin Chang, Tao Wang
Summary: This research developed a microRNA-responsive nanomedicine that uses microRNA-21 as a trigger for killing cancer cells, aiming to enhance treatment effectiveness.
Article
Oncology
Xin Gao, Chenguang Wang, Suhaib Abdelrahman, Nermin Kady, Carlos Murga-Zamalloa, Peter Gann, Maria Sverdlov, Ashley Wolfe, Avery Polk, Noah Brown, Nathanael G. Bailey, Kedar Inamdar, Sandro Casavilca-Zambrano, Jaime Montes, Carlos Barrionuevo, Luis Taxa, John Reneau, Christian W. Siebel, Ivan Maillard, Ryan A. Wilcox
Summary: Notch signaling pathway plays a crucial role in the pathogenesis of peripheral T-cell lymphoma, and Notch1 activation is associated with proliferation. Blockade of Notch1/Notch2 and DLL1/DLL4 can inhibit the proliferation of malignant T cells and tumor progression.
Review
Microbiology
Mohd W. Azam, Raffaele Zarrilli, Asad U. Khan
Summary: The Enterobacterales order is a large group of Gram-negative bacteria that includes both pathogenic and nonpathogenic members, including beneficial gut microbiota. Pathogenic members produce virulence factors and display antimicrobial resistance. This review focuses on the virulence factors, pathogenicity, and infections caused by multidrug-resistant Enterobacterales, particularly E. coli and similar bacterial species. The review also discusses different approaches for combating these infections. Understanding the virulence factors of pathogenic bacteria can aid in the development of novel strategies to treat infections caused by them.
Article
Immunology
Shinya Yari, Junichi Kikuta, Hotaka Shigyo, Yu Miyamoto, Daisuke Okuzaki, Yuki Furusawa, Masafumi Minoshima, Kazuya Kikuchi, Masaru Ishii
Summary: This study found that a JAK inhibitor suppresses bone resorption by blocking the function of mature osteoclasts and targeting the migratory behaviors of osteoclast precursors to the bone surface. Further molecular mechanism studies revealed that the JAK inhibitor inhibits bone destruction under inflammatory conditions by suppressing Ccr1 expression on osteoclast precursors.
INFLAMMATION AND REGENERATION
(2023)
Article
Multidisciplinary Sciences
Takuro Kobori, Mayuka Tameishi, Chihiro Tanaka, Yoko Urashima, Tokio Obata
Summary: The ERM family proteins ezrin, radixin, and moesin play a crucial role in regulating P-gp's plasma membrane localization and transport function in cancer cells. The study showed that ezrin mainly regulates P-gp's cell surface expression and transport function without affecting its mRNA expression in LS180 cells. These findings could be important for developing treatments for colorectal cancer, a leading cause of cancer-related deaths.
Article
Hematology
Megan E. Zavorka Thomas, Jae Yoon Jeon, Zahra Talebi, Daelynn R. Buelow, Josie Silvaroli, Moray J. Campbell, Alex Sparreboom, Navjot Pabla, Sharyn D. Baker
Summary: The study identified calcium-binding proteins S100A8 and S100A9 as contributors to gilteritinib resistance in FLT3-ITD+ AML, indicating that targeting these proteins could enhance the anti-leukemic effects of gilteritinib.
Article
Chemistry, Multidisciplinary
Wojciech Wojcik, Krzysztof Damaziak, Monika Lukasiewicz-Mierzejewska, Olga Swider, Jan Niemiec, Michal Wojcicki, Marek Roszko, Dariusz Gozdowski, Julia Riedel, Agata Marzec
Summary: This study aimed to determine the formation of biogenic amines (BAs) and their precursor amino acids in chicken breast and leg muscles stored under chilling conditions. The results showed a significant increase in BAs in both muscle types during storage, and distinct levels of BAs were detected in the muscles.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Muhammad Aamir Manzoor, Guohui Li, Muhammad Abdullah, Wang Han, Han Wenlong, Zhang Yang, Wang Xinya, Zhao Yu, Feng Xiaofeng, Jin Qing, Muhammad Sohaib Shafique, Yongping Cai
Summary: In this study, 404 MATE genes from six Rosaceae genomes were identified and classified into eight main subfamilies based on structural and phylogenetic analysis. The results suggest that whole-genome duplication events may have played a vital role in the expansion of the MATE genes family. The analysis revealed functional divergence among different subfamilies, providing insights into the functions, expansion complexity, and evolutions of the MATE genes in Chinese pear and five Rosaceae species.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Hematology
Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Ounap, Tiit Ord, Heidi H. Pulkkinen, Petri Polonen, Merja Heinaniemi, Seppo Yla-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen
Summary: This study aimed to characterize microRNA-related regulatory mechanisms in the aorta during atherosclerosis. The research analyzed miRNA expression changes in different cell types under proatherogenic stimuli and found common miRNA species dominating in all cell types. The study identified potential mechanisms by which miRNAs affect atherogenesis in a cell-type-specific manner.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Sara Petrin, Massimiliano Orsini, Andrea Massaro, John E. Olsen, Lisa Barco, Carmen Losasso
Summary: The antimicrobial resistance among zoonotic pathogens, such as Salmonella, is a serious health threat. This study investigated the phenotypic antimicrobial resistance and identified the antimicrobial resistance genes (ARGs) and plasmid replicons associated with the resistances. The results showed a high level of variability in ARGs and plasmid replicons content among different serovars of Salmonella enterica.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Analytical
Liang Dong, Chung-Ying Huang, Eric J. Johnson, Lei Yang, Richard C. Zieren, Kengo Horie, Chi-Ju Kim, Sarah Warren, Sarah R. Amend, Wei Xue, Kenneth J. Pienta
Summary: Extracellular vesicles (EVs) are important players in intercellular communication, with mRNA transcripts in EVs potentially contributing to cancer progression. The cargo of EVs is not completely reflective of their cell origin, indicating a complex mechanism of cargo sorting that requires further elucidation.
ANALYTICAL CHEMISTRY
(2021)
Article
Microbiology
Meinan Lyu, Julio C. Ayala, Isabella Chirakos, Chih-Chia Su, William M. Shafer, Edward W. Yu
Summary: In this study, a cationic antibiotic-sensitizing peptide (CASP) that binds to the periplasmic cleft of a specific RND transporter protein was identified. CASP was found to render Gram-negative rod-shaped bacteria susceptible to an antibiotic that is normally exported by the RND efflux pump. CASP (or its derivatives) could be used as an adjuvant to treat multidrug-resistant infections caused by RND transporters.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Applied
Anna Dzimitrowicz, Piotr Jamroz, Piotr Cyganowski, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl
Summary: By controlling cold atmospheric pressure plasma (CAPP) treatment, the element composition pattern and phenolic compound content of beetroot juice were altered, inhibiting the proliferation of colorectal adenocarcinoma cell lines while exhibiting non-cytotoxic effects on non-malignant endothelial cells, resulting in a safe-to-consume beetroot juice with improved nutritional quality.
Review
Engineering, Chemical
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: Cold atmospheric pressure plasmas (CAPPs) have attracted increasing attention in the field of medicine, particularly in oncology. The selective anticancer characteristics of CAPP make it a promising application for treating skin cancers. Research on the effects of CAPP on skin cancers has provided insights into potential new treatments and the complex interactions between reactive species and cellular components.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2021)
Article
Immunology
Joanna Cwykiel, Arkadiusz Jundzill, Aleksandra Klimczak, Maria Madajka-Niemeyer, Maria Siemionow
Summary: The study assessed the efficacy of DRCC therapy in a rat VCA model, showing that the therapy induced long-term chimerism and extended VCA survival. DRCC introduces a novel concept of customized donor-recipient cell-based therapy supporting solid organ and VCA transplants.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2021)
Article
Biochemistry & Molecular Biology
Dominik Terefinko, Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Aleksandra Klimczak, Pawel Pohl, Piotr Jamroz
Summary: The research demonstrates that treating media with CAPP for 180 seconds significantly reduces cell viability and migration of MDA-MB-231 cells, while also disrupting the life processes of MCF7 cells. Furthermore, CAPP-activated media leads to the apoptosis of the analyzed cell lines, especially the metastatic MDA-MB-231 cell line. This suggests that the application of the CAPP system may serve as a potential therapeutic strategy for managing highly metastatic human breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Urszula Kozlowska, Charles Nichols, Kalina Wiatr, Maciej Figiel
Summary: Studies on psychedelics, particularly psilocybin, are gaining interest in neuroscience research due to their potential therapeutic effects on psychiatric illnesses like depression. Recent research suggests that psychedelics may not only treat conditions like major depressive disorder, but also have benefits in treating brain injuries and neurodegenerative diseases. Their exact molecular mechanisms and interactions within the central nervous system during brain injuries and neurodegenerative diseases are still being investigated.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Cell Biology
Sandra Stamnitz, Aleksandra Klimczak
Summary: Mesenchymal stem cell-based therapies show promise in bone tissue regeneration, but cell tracking and maintenance in the injury site pose challenges. Seeding cells onto a biocompatible scaffold may offer a potential solution. The development of bone tissue engineering involves optimizing various variables like stem cell source, osteogenic molecular factors, scaffold design, and suitable animal models.
Article
Cell Biology
Urszula Kozlowska, Aleksandra Klimczak, Karolina Anna Bednarowicz, Tomasz Zalewski, Natalia Rozwadowska, Katarzyna Chojnacka, Stefan Jurga, Eytan R. Barnea, Maciej K. Kurpisz
Summary: This study aimed to investigate the efficiency of glial restricted progenitors (GRPs) grafted into murine CNS in different immune environments, and to study the effects of various immunosuppressive/immunomodulatory regimens on their survival and immune response.
Article
Biochemistry & Molecular Biology
Honorata Kraskiewicz, Piotr Hinc, Agnieszka Krawczenko, Aleksandra Bielawska-Pohl, Maria Paprocka, Danuta Witkowska, Isma Liza Mohd Isa, Abhay Pandit, Aleksandra Klimczak
Summary: A potential treatment for chronic wounds using a hydrogel loaded with secretome from adipose tissue mesenchymal stem cells has been proposed. The biocompatibility and pro-angiogenic activity of the hydrogel-released factors were investigated, showing positive effects on skin-origin cell proliferation and endothelial cell angiogenic properties. Additionally, antimicrobial activity was observed in the secretome, indicating its potential use as an advanced wound-healing dressing in combination with the hydrogel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Krawczenko, Aleksandra Klimczak
Summary: MSCs, known for their regenerative and immunomodulatory properties, are typically isolated from bone marrow and adipose tissue. This review focuses on MSCs derived from adipose tissue and their secretome in regeneration processes, with a special emphasis on their contribution to angiogenic processes. Various clinical trials have been registered to explore the application of AT-MSCs and their secretome in treating different medical conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Julia K. Bar, Tomasz Kowalczyk, Piotr G. Grelewski, Sandra Stamnitz, Maria Paprocka, Joanna Lis, Anna Lis-Nawara, Seongpil An, Aleksandra Klimczak
Summary: This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrolytically-modified PLCL nanofiber scaffold. The results showed that the PLCL scaffold significantly supported hDPSC viability/proliferation and their osteogenic differentiation. These findings suggest the potential application of modified PLCL scaffold in bone tissue engineering.
Editorial Material
Biochemistry & Molecular Biology
Aleksandra Klimczak
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Meriem Baouche, Agnieszka Krawczenko, Maria Paprocka, Aleksandra Klimczak, Pascal Mermillod, Yann Locatelli, Malgorzata Ochota, Wojciech Nizanski
Summary: This study investigates whether cells derived from the feline umbilical cord exhibit mesenchymal stromal/stem cells (MSCs) characteristics. The results show that MSCs derived from Wharton's jelly have the best proliferation ability, pluripotency gene expressions, and differentiation potential, making them the most valuable for feline regenerative medicine.
Article
Biochemistry & Molecular Biology
Agnieszka Szyposzynska, Aleksandra Bielawska-Pohl, Marek Murawski, Rafal Sozanski, Grzegorz Chodaczek, Aleksandra Klimczak
Summary: The study demonstrates that HATMSC2 microvesicles can reduce metabolic activity and induce cancer cell death in primary ovarian cancer cells, leading to decreased migratory activity. The anti-cancer effect is likely contributed by the delivery of specific molecules that induce cell cycle arrest and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)