Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling
Published 2017 View Full Article
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Title
Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling
Authors
Keywords
Bone development, Tibia, Osteoblasts, Analysis of variance, Bone fracture, Gene expression, Wnt signaling cascade, Bone remodeling
Journal
PLoS One
Volume 12, Issue 11, Pages e0187980
Publisher
Public Library of Science (PLoS)
Online
2017-11-18
DOI
10.1371/journal.pone.0187980
References
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Related references
Note: Only part of the references are listed.- Connexins in the skeleton
- (2016) Joseph P. Stains et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
- (2016) Monica Florio et al. Nature Communications
- Connexins and pannexins in the skeleton: gap junctions, hemichannels and more
- (2015) Lilian I. Plotkin et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats
- (2014) Marina Stolina et al. BONE
- Mechanisms linking connexin mutations to human diseases
- (2014) John J. Kelly et al. CELL AND TISSUE RESEARCH
- Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway
- (2014) Alyson Morse et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43
- (2013) Joseph P. Stains et al. CALCIFIED TISSUE INTERNATIONAL
- Load Regulates Bone Formation and Sclerostin Expression through a TGFβ-Dependent Mechanism
- (2013) Jacqueline Nguyen et al. PLoS One
- Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice
- (2012) Marcus P. Watkins et al. BONE
- Wnt/β-Catenin Signaling and Disease
- (2012) Hans Clevers et al. CELL
- Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice
- (2012) Susan K. Grimston et al. PLoS One
- Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis
- (2011) Susan K Grimston et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
- (2011) Nicoletta Bivi et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling
- (2011) Marcus Watkins et al. MOLECULAR BIOLOGY OF THE CELL
- Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered
- (2011) A. Moustafa et al. OSTEOPOROSIS INTERNATIONAL
- N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
- (2010) A. Di Benedetto et al. JOURNAL OF CELL SCIENCE
- Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling
- (2009) Chuwen Lin et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
- (2008) Xiaodong Li et al. JOURNAL OF BONE AND MINERAL RESEARCH
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