Targeting the permeability barrier and peptidoglycan recycling pathways to disarm Pseudomonas aeruginosa against the innate immune system

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance

(2016) G. Evan Perley-Robertson et al.   ACS Chemical Biology

Considerations and caveats in anti-virulence drug development

(2016) Damien Maura et al.   CURRENT OPINION IN MICROBIOLOGY

Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development

(2016) Ryan P Lamers et al.   Future Medicinal Chemistry

Recombinant Human Peptidoglycan Recognition Proteins Reveal Antichlamydial Activity

(2016) Pavel Bobrovsky et al.   INFECTION AND IMMUNITY

Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli

(2016) Antoine Delhaye et al.   mBio

Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway?

(2016) Marcelo Pérez-Gallego et al.   mBio

Role of Pseudomonas aeruginosa Low-Molecular-Mass Penicillin-Binding Proteins in AmpC Expression, β-Lactam Resistance, and Peptidoglycan Structure

(2015) Alaa Ropy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The cell wall amidase AmiB is essential forPseudomonas aeruginosacell division, drug resistance and viability

(2015) Anastasiya A. Yakhnina et al.   MOLECULAR MICROBIOLOGY

Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4

(2015) Ranjita N. Gowda et al.   PLoS One

The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa

(2014) Jed F. Fisher et al.   BIOORGANIC CHEMISTRY

The fitness costs of antibiotic resistance mutations

(2014) Anita H. Melnyk et al.   Evolutionary Applications

The Cpx Envelope Stress Response Modifies Peptidoglycan Cross-Linking via the l,d-Transpeptidase LdtD and the Novel Protein YgaU

(2014) Margarita Bernal-Cabas et al.   JOURNAL OF BACTERIOLOGY

Different walls for rods and balls: the diversity of peptidoglycan

(2014) Robert D. Turner et al.   MOLECULAR MICROBIOLOGY

A Novel Peptidoglycan Binding Protein Crucial for PBP1A-Mediated Cell Wall Biogenesis in Vibrio cholerae

(2014) Tobias Dörr et al.   PLoS Genetics

Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative, Thiol, and Metal Stress

(2014) Des Raj Kashyap et al.   PLoS Pathogens

Bioengineered lysozyme in combination therapies forPseudomonas aeruginosalung infections

(2014) Karl E Griswold et al.   Bioengineered

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

(2013) Keith A. Stubbs et al.   CHEMBIOCHEM

Inheritance of the Lysozyme Inhibitor Ivy Was an Important Evolutionary Step by Yersinia pestis to Avoid the Host Innate Immune Response

(2013) Anne Derbise et al.   JOURNAL OF INFECTIOUS DISEASES

Reactions of the Three AmpD Enzymes of Pseudomonas aeruginosa

(2013) Weilie Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical Use of Colistin Induces Cross-Resistance to Host Antimicrobials in Acinetobacter baumannii

(2013) B. A. Napier et al.   mBio

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

(2013) Shaan L. Gellatly et al.   Pathogens and Disease

Role of Mouse Peptidoglycan Recognition Protein PGLYRP2 in the Innate Immune Response to Salmonella enterica Serovar Typhimurium InfectionIn Vivo

(2012) Jooeun Lee et al.   INFECTION AND IMMUNITY

The Lysozyme-Induced Peptidoglycan N-Acetylglucosamine Deacetylase PgdA (EF1843) Is Required for Enterococcus faecalis Virulence

(2012) A. Benachour et al.   JOURNAL OF BACTERIOLOGY

Mammalian Peptidoglycan Recognition Proteins Kill Bacteria by Activating Two-Component Systems and Modulate Microbiome and Inflammation

(2012) Roman Dziarski et al.   Microbial Drug Resistance

A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

(2012) Deepak Balasubramanian et al.   NUCLEIC ACIDS RESEARCH

AmpG Inactivation Restores Susceptibility of Pan-β-Lactam-Resistant Pseudomonas aeruginosa Clinical Strains

(2011) Laura Zamorano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Providing β-lactams a helping hand: targeting the AmpC β-lactamase induction pathway

(2011) Brian L Mark et al.   Future Microbiology

Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

(2011) Matthew T. Sorbara et al.   IMMUNOLOGICAL REVIEWS

Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems

(2011) Des Raj Kashyap et al.   NATURE MEDICINE

Pseudomonas aeruginosa: all roads lead to resistance

(2011) Elena B.M. Breidenstein et al.   TRENDS IN MICROBIOLOGY

Enhanced Antimicrobial Activity of Engineered Human Lysozyme

(2010) Thomas C. Scanlon et al.   ACS Chemical Biology

NagZ Inactivation Prevents and Reverts  -Lactam Resistance, Driven by AmpD and PBP 4 Mutations, in Pseudomonas aeruginosa

(2010) L. Zamorano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Vertebrate Lysozyme Inhibitor Ivy Functions to Inhibit the Activity of Lytic Transglycosylase

(2010) Chelsea A. Clarke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysozymes in the animal kingdom

(2010) Lien Callewaert et al.   JOURNAL OF BIOSCIENCES

Mammalian PGRPs in the Spotlight

(2009) Ivo Gomperts Boneca   Cell Host & Microbe

PGLYRP-2 and Nod2 Are Both Required for Peptidoglycan-Induced Arthritis and Local Inflammation

(2009) Sukumar Saha et al.   Cell Host & Microbe

Pseudomonas aeruginosa Exploits Lipid A and Muropeptides Modification as a Strategy to Lower Innate Immunity during Cystic Fibrosis Lung Infection

(2009) Cristina Cigana et al.   PLoS One

Role of the Lysozyme Inhibitor Ivy in Growth or Survival of Escherichia coli and Pseudomonas aeruginosa Bacteria in Hen Egg White and in Human Saliva and Breast Milk

(2008) D. Deckers et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

High salt stress in Bacillus subtilis: involvement of PBP4* as a peptidoglycan hydrolase

(2008) María Mercedes Palomino et al.   RESEARCH IN MICROBIOLOGY

A New Family of Lysozyme Inhibitors Contributing to Lysozyme Tolerance in Gram-Negative Bacteria

(2008) Lien Callewaert et al.   PLoS Pathogens