Review
Food Science & Technology
Osman N. Kanwugu, Tatiana Glukhareva, Irina G. Danilova, Elena G. Kovaleva
Summary: Diabetes is a major health emergency worldwide, affecting millions of people. Oxidative stress and inflammation play key roles in the development of diabetes and its complications. Astaxanthin, a powerful antioxidant found in marine organisms, has shown potential benefits in the treatment and management of diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Stephanie MacKenzie, Andreas Bergdahl
Summary: Oxidative stress is a major factor in the development of diabetes and its complications, and zinc plays a significant role in protecting against this stress. Zinc dysregulation is associated with diabetes and may contribute to vascular changes caused by the disease. Zinc supplementation has been shown to be beneficial in preventing and mitigating oxidative stress and its consequences.
Review
Biochemistry & Molecular Biology
Paula Poyatos, Miquel Gratacos, Kay Samuel, Ramon Orriols, Olga Tura-Ceide
Summary: Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Several studies have shown evidence of the critical role of oxidative stress in PH pathophysiology.
Article
Biochemistry & Molecular Biology
Junping Deng, Jie Gu, Xiaoxue Zhao, Bowen Yan, Lei Wang, Guixiang Ji, Caoxing Huang
Summary: In this study, lignin nanoparticles (L-NANO) were prepared through high-pressure homogenization, which resulted in increased functional group contents and improved bioactivity. L-NANO exhibited protective effects on the cardiovascular and neural development of BPAF-induced zebrafish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chindiana Khutami, Sri Adi Sumiwi, Nur Kusaira Khairul Ikram, Muchtaridi Muchtaridi
Summary: This review discusses the activity of antioxidant compounds against obesity, dyslipidemia, and diabetes, along with their molecular signaling mechanisms. These antioxidant compounds exhibit activity against the three metabolic disorders through various molecular signaling pathways, and further research may help in predicting drug targets for optimal effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yi-Jen Hsueh, Yen-Ning Chen, Yu-Ting Tsao, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen
Summary: This article summarizes and provides updates on the research and treatment methods of ocular degenerative diseases related to oxidative stress. The article reviews the oxidative damage that occurs in different areas of the eye and introduces the antioxidant mechanisms present in the eye as well as the ocular diseases that occur as a result of antioxidant imbalances and relevant biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Rui Wang, Jinjin Pan, Jinzhen Han, Miaomiao Gong, Liang Liu, Yunlong Zhang, Ying Liu, Dingyou Wang, Qing Tang, Na Wu, Lin Wang, Jinsong Yan, Hua Li, Yuhui Yuan
Summary: This study demonstrates that melatonin can alleviate dasatinib-aggravated hypoxic pulmonary hypertension by inhibiting pulmonary vascular remodeling and protecting endothelial cells and inhibiting abnormal proliferation of smooth muscle cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Fatima Zahra Kamal, Radu Lefter, Hassna Jaber, Ioana-Miruna Balmus, Alin Ciobica, Alin-Constantin Iordache
Summary: Ischemic strokes occur due to arterial blockage, leading to interrupted blood supply to the brain and potential damage or death of brain cells. Oxidative stress is an essential mechanism in ischemic stroke, and the assessment of oxidative stress biomarkers can aid in diagnosing the severity and guiding neuroprotective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Estefania Bravo-Sanchez, Donovan Pena-Montes, Sarai Sanchez-Duarte, Alfredo Saavedra-Molina, Elizabeth Sanchez-Duarte, Rocio Montoya-Perez
Summary: The study showed that treatment with apocynin significantly improved blood glucose levels and insulin resistance in diabetic rats, attenuated oxidative stress responses, enhanced mitochondrial function and antioxidant defense. Apocynin has a protective effect against diabetic complications.
Article
Biochemistry & Molecular Biology
Ji-Min Lv, Mostafa Gouda, Xing-Qian Ye, Zhi-Peng Shao, Jian-Chu Chen
Summary: In this study, the protective effect of purified kiwi leaves PAs (PKLPs) on oxidative stress mechanisms in Caco-2 cells was investigated. The results demonstrated that PKLPs can reduce oxidative damage by regulating the Nrf2-ARE signaling pathway.
Article
Endocrinology & Metabolism
Cheng-Chen Deng, Ji-Pan Zhang, Yuan-Nan Huo, Hong-Yan Xue, Wenxiu Wang, Jiao-Jiao Zhang, Xian-Zhong Wang
Summary: This study revealed the impact of heat stress on glucose metabolism in Sertoli cells and the protective mechanisms of melatonin on Sertoli cells under heat stress through different signaling pathways.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Qin Fang, Yang Bai, Shuiqing Hu, Jie Ding, Lei Liu, Meiyan Dai, Jie Qiu, Lujin Wu, Xiaoquan Rao, Yan Wang
Summary: This review article explores the role and mechanism of Nrf2 in pulmonary vascular remodeling associated with PH, as well as summarizes the therapeutic potential of Nrf2 inducers.
Review
Biochemistry & Molecular Biology
Lital Argaev-Frenkel, Tovit Rosenzweig
Summary: Oxidative stress is a crucial factor in the development of type 2 diabetes (T2D) and its associated complications. However, there is insufficient evidence to support the effectiveness of antioxidants (AOXs) in treating this disease. Inappropriate dosing of AOXs and the individual variation in the presence and severity of oxidative stress may explain the lack of benefits from AOX therapy.
Article
Biochemistry & Molecular Biology
Hongbing Fan, Khushwant S. Bhullar, Jianping Wu
Summary: The study identified bioactive peptides from spent hen muscle proteins that exhibited antioxidant and cytoprotective activities in vascular cells under oxidative stress. These peptides attenuated oxidative stress in vascular cells and showed potential as functional food ingredients for hypertension treatment, with V-F peptide potentially acting through increased endogenous antioxidant enzymes.
Review
Biochemistry & Molecular Biology
Narasimha M. Beeraka, Irina K. Tomilova, Galina A. Batrak, Maria V. Zhaburina, Vladimir N. Nikolenko, Mikhail Y. Sinelnikov, Liudmila M. Mikhaleva
Summary: Diabetes mellitus and its associated vascular complications have a significant impact on patient quality of life. Free radical oxidation is recognized as a main mechanism in the development of diabetes and its complications. Imbalance between the antioxidant defense system and pro-oxidants during chronic hyperglycemia leads to excess free radical formation and activation of lipid peroxidation. Antioxidants may play a positive role in preventing diabetes-induced vascular complications.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Valerie Capra, G. Enrico Rovati, Paolo Mangano, Carola Buccellati, Robert C. Murphy, Angelo Sala
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2015)
Article
Nutrition & Dietetics
Marianela Vara-Messler, Maria E. Pasqualini, Andrea Comba, Renata Silva, Carola Buccellati, Annalisa Trenti, Lucia Trevisi, Aldo R. Eynard, Angelo Sala, Chiara Bolego, Mirta A. Valentich
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Immunology
Lavinia Vocca, Caterina Di Sano, Carina G. Uasuf, Angelo Sala, Oredana Riccobono, Sebastiano Gangemi, Giusy Daniela Albano, Anna Bonanno, Rosalia Gagliardo, Mirella Profita
Article
Medicine, Research & Experimental
Fabio Stellari, Angelo Sala, Francesca Ruscitti, Chiara Carnini, Prisco Mirandola, Marco Vitale, Maurizio Civelli, Gino Villetti
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Article
Pharmacology & Pharmacy
S. Manzini, C. Pinna, M. Busnelli, P. Cinquanta, E. Rigamonti, G. S. Ganzetti, F. Dellera, A. Sala, L. Calabresi, G. Franceschini, C. Parolini, G. Chiesa
VASCULAR PHARMACOLOGY
(2015)
Correction
Nutrition & Dietetics
Marianela Vara-Messler, Maria E. Pasqualini, Andrea Comba, Renata Silva, Carola Buccellati, Annalisa Trenti, Lucia Trevisi, Aldo R. Eynard, Angelo Sala, Chiara Bolego, Mirta A. Valentich
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Pharmacology & Pharmacy
Malvina Hoxha, Carola Buccellati, Valerie Capra, Davide Garella, Clara Cena, Barbara Rolando, Roberta Fruttero, Silvia Carnevali, Angelo Sala, G. Enrico Rovati, Massimo Bertinaria
PHARMACOLOGICAL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Anna Bonanno, Giusy Daniela Albano, Liboria Siena, Angela Marina Montalbano, Loredana Riccobono, Giulia Anzalone, Giuseppina Chiappara, Rosalia Gagliardo, Mirella Profita, Angelo Sala
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2016)
Article
Clinical Neurology
Massimo Allegri, Dario Bugada, Manuela De Gregori, Maria A. Avanzini, Annalisa De Silvestri, Anna Petroni, Angelo Sala, Claudia Filisetti, Antonia Icaro Cornaglia, Lorenzo Cobianchi
JOURNAL OF PAIN RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Angelo Sala, Ewgenij Proschak, Dieter Steinhilber, G. Enrico Rovati
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Nutrition & Dietetics
Monica Gianna Giroli, Jose Pablo Werba, Patrizia Rise, Benedetta Porro, Angelo Sala, Manuela Amato, Elena Tremoli, Alice Bonomi, Fabrizio Veglia
Summary: The study found that compared to a low-fat diet, the Mediterranean diet had a more favorable effect on blood fatty acid composition in patients with coronary heart disease on multiple therapies, particularly in terms of omega-3 levels.
Article
Biochemistry & Molecular Biology
Elvira Verduci, Patrizia Rise, Elisabetta Di Profio, Laura Fiori, Sara Vizzuso, Dario Dilillo, Savina Mannarino, Elena Zoia, Valeria Calcaterra, Christian Pinna, Angelo Sala, Gianvincenzo Zuccotti
Summary: MIS-C is a pathological state linked to SARS-CoV-2 infection in children, characterized by inflammation, multisystem involvement, and altered inflammatory markers. The study reveals significant alterations in fatty acid levels in children with MIS-C, suggesting a potential contribution of omega-6 fatty acids to the observed inflammatory state.
Article
Biochemical Research Methods
Giuseppe Santini, Nadia Mores, Rugia Shohreh, Salvatore Valente, Malgorzata Dabrowska, Andrea Trove, Gina Zini, Paola Cattani, Leonello Fuso, Antonella Mautone, Chiara Mondino, Gabriella Pagliari, Angelo Sala, Giancarlo Folco, Marina Aiello, Roberta Pisi, Alfredo Chetta, Monica Losi, Enrico Clini, Giovanni Ciabattoni, Paolo Montuschi
JOURNAL OF BREATH RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Nadia Moretto, Paola Caruso, Raffaella Bosco, Gessica Marchini, Fiorella Pastore, Elisabetta Armani, Gabriele Amari, Andrea Rizzi, Eleonora Ghidini, Renato De Fanti, Carmelida Capaldi, Laura Carzaniga, Emilio Hirsch, Carola Buccellati, Angelo Sala, Chiara Carnini, Riccardo Patacchini, Maurizio Delcanale, Maurizio Civelli, Gino Villetti, Fabrizio Facchinetti
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2015)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.