Article
Chemistry, Applied
Hongbing Fan, Jianping Wu
Summary: The study investigated the use of spent hen as a starting material for preparing antihypertensive peptides with both ACE inhibitory (ACEi) and ACE2 upregulating (ACE2u) activities. Several potent ACEi and ACE2u peptides were identified, supporting the potential use of spent hens as functional food ingredients and nutraceuticals for hypertension treatment.
Article
Agriculture, Multidisciplinary
Hongbing Fan, Wang Liao, Sandra T. Davidge, Jianping Wu
Summary: This study found that chicken muscle-derived peptide V-F can alleviate Ang II-induced inflammation in vascular smooth muscle cells through the ACE2/Ang (1-7)/MasR pathway, supporting its application in the prevention and treatment of hypertension and cardiovascular diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Michal Kluknavsky, Andrea Micurova, Martina Cebova, Ezgi Saman, Sona Cacanyiova, Iveta Bernatova
Summary: MLN-4760 did not worsen pre-existing hypertension and behavioral hyperactivity/anxiety in SHRs. However, MLN-4760-induced oxidative damage in the brainstem was associated with activation of NO- and H2S-mediated compensatory mechanisms and increased expression of antioxidant, NO and H2S-producing enzymes, which correlated positively with elevated Nfe2l2 expression.
Article
Agriculture, Dairy & Animal Science
Yoo-Bhin Kim, Sang-Hyeok Lee, Da-Hye Kim, Hyun-Gwan Lee, Yongjun Choi, Sung-Dae Lee, Kyung-Woo Lee
Summary: This study aimed to evaluate the effects of organic and inorganic sulfur on laying hens. The results showed that both types of sulfur had positive effects on ileal morphology and antioxidant capacity in laying hens. However, sodium sulfate inhibited laying performance and further research is needed.
Article
Agriculture, Dairy & Animal Science
Fang Chen, Hao Zhang, Encun Du, Feng Jin, Chao Zheng, Qiwen Fan, Na Zhao, Wanzheng Guo, Wei Zhang, Shaowen Huang, Jintao Wei
Summary: The study showed that dietary supplementation of 200 and 300 mg/kg magnolol can improve hen performance, albumen quality of fresh and storage eggs, and hepatic lipid metabolism in the late laying cycle. Additionally, magnolol has a beneficial effect on increasing villi and improving the intestinal mucosal mechanical barrier function.
Article
Food Science & Technology
Chuqiao Xiao, Fidel Toldra, Mouming Zhao, Feibai Zhou, Donghui Luo, Ruibo Jia, Leticia Mora
Summary: The study found that chicken hydrolysates exhibited significant antioxidant activity and could resist simulated gastrointestinal digestion. Novel peptides RWGG and YYCQ showed strong antioxidant activity.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Dairy & Animal Science
Y. F. Gu, Y. P. Chen, R. Jin, C. Wang, C. Wen, Y. M. Zhou
Summary: The study revealed that with increasing age, the hepatic metabolism and antioxidant capacity of laying hens undergo changes, leading to reduced liver function in older hens compared to younger ones.
Article
Agriculture, Dairy & Animal Science
Xiaodi E, Dan Shao, Mengmei Li, Shourong Shi, Yunqi Xiao
Summary: The effects of supplemental genistein on laying hens during the late laying period were evaluated. The results showed that genistein supplementation improved laying rate, eggshell quality, and antioxidant capacity in the hens. The optimal dosage was found to be 120 mg/kg of genistein.
Article
Biochemistry & Molecular Biology
Yoo-Bhin Kim, Sang-Hyeok Lee, Da-Hye Kim, Hyun-Gwan Lee, Yong-Sung Jeon, Sung-Dae Lee, Kyung-Woo Lee
Summary: This study evaluated the effects of dietary methyl sulfonyl methane (MSM) on laying hens. The results showed that increasing levels of MSM had a quadratic effect on feed intake and conversion ratio. However, egg qualities and components were not affected. Dietary MSM increased the deposition of MSM in egg albumens and decreased the concentration of malondialdehyde in egg yolks. It also affected indicators of antioxidant/oxidative stress in serum samples. The study suggests that MSM can be used as an antioxidant feed additive for laying hens.
Article
Agriculture, Multidisciplinary
Lanlan Li, Yue Zhu, Shuangshuang Zhang, Jihua Wang, Shuangshuang Guo, Binying Ding, Zhengfan Zhang
Summary: The supplementation of GCM has positive effects on reducing egg loss and improving egg quality in laying hens.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Microbiology
Hengyong Xu, Yuxiang Lu, Dan Li, Chaoyang Yan, Yuru Jiang, Zhi Hu, Zhipeng Zhang, Ranran Du, Xiaoling Zhao, Yao Zhang, Yaofu Tian, Qing Zhu, Yiping Liu, Yan Wang
Summary: This study investigated the effects of dietary probiotics supplementation on laying performance, egg quality, serum hormone levels, immunity, antioxidant, and gut microbiota of layers at different laying stages. The results showed that the addition of probiotics improved egg weight, egg quality, ovarian development, hormone levels, antioxidant indices, and decreased proinflammatory factors. Probiotics also influenced the distribution and abundance of different bacterial phyla in the gut microbiota of laying hens at different laying stages. Furthermore, probiotics supplementation enriched important gene clusters related to metabolism, genetic information processing, and decreased the proportion of potential pathogenic bacteria. Overall, adding probiotics enhanced the performance, egg quality, immune function, and gut microbiota of layers, leading to improved production efficiency.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Gozde Kilinc, Sakine Yalcin, Suzan Yalcin
Summary: This study investigated the effects of dietary supplementation with dried wild leek (Allium scorodoprasum L. subsp. rotundum) leaves on laying performance, egg quality, antioxidant status, and oxidative stability in laying hens. The results showed that supplementation with 3 g/kg dried wild leek leaves improved egg weight, feed efficiency, DPPH radical scavenging activity, and antioxidant status in egg yolk. Therefore, adding dried wild leek leaves to laying hen diets can help produce functional eggs with low cholesterol and high antioxidants.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Veterinary Sciences
Katrin Roehm, Martin Diener, Korinna Huber, Jana Seifert
Summary: The study focused on the ex vivo characterization of cecal smooth muscle contraction in laying hens, showing that the use of calcium-free buffer decreases muscle contraction, while carbachol increases it. Nitroprusside, isoprenaline and Verapamil inhibit smooth muscle contraction.
VETERINARY SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Ling Zhou, Xuemei Ding, Jianping Wang, Shiping Bai, Qiufeng Zeng, Zuowei Su, Yue Xuan, Keying Zhang
Summary: Ageing corn negatively impacts the performance, egg quality, and antioxidant status of laying hens, while supplementation with tea polyphenols can partially mitigate these adverse effects.
Article
Agriculture, Dairy & Animal Science
Weizhao He, Hao Wang, Chaohua Tang, Qingyu Zhao, Junmin Zhang
Summary: This study investigated the effects of astaxanthin supplementation on the egg quality, antioxidant capacity, and ovarian aging of aged laying hens. The results showed that astaxanthin improved egg yolk color and Haugh unit, increased the number of follicles in the ovary and reduced atresia. Astaxanthin also enhanced the antioxidant capacity, reduced cellular apoptosis, and improved serum reproductive hormone levels.
Article
Agronomy
Liang Zhang, Zhiyu Zhu, Fangfang Chen, Yueqing Zhu, Xiaocan Guo, Minjie Fu, Jiahong Chen, Jianguo Wu, Zhujun Zhu
Summary: In this study, distant hybridization between radish and kohlrabi was successfully achieved using tissue culture and chromosome doubling technology, resulting in the production of xBrassicoraphanus allotetraploids. The allotetraploid hybrids exhibited normal morphology and fertility, providing a basis for the production of new radish germplasm and serving as a bridge for gene transfer between Brassica and Raphanus vegetable species.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Xiao-Fan Chen, Zhi-Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi-Feng Chen
Summary: Exposure to pollutants can cause damage to the eyes of aquatic organisms. Zebrafish is a commonly used model to study ocular toxicity and has shown morphological changes, retinal damage, and abnormalities in visual signal processes. The underlying mechanisms involve thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. This review discusses the phenotypes and signaling pathways associated with ocular toxicity from contaminants, detection methods, and a predictive model for potential ocular toxicity.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Geosciences, Multidisciplinary
Yongjie Wang, Guitao Shi, Danhe Wang, Qian Zhao, Su Jiang, Yangjie Li, Dongqi Wang, Chuanjin Li, Zhenlou Chen, Roberto Bargagli
Summary: This study investigated soil mercury levels in different areas of Antarctica and found a close relationship between mercury distribution and organic carbon content. The findings contribute to a better understanding of the biogeochemical cycle of mercury in Antarctic terrestrial ecosystems.
Article
Plant Sciences
Yan Wang, Wei Dong, Qin Zhang, Zhen-Peng Li, Yue-Xing Wang, Xiu-Fen Li, Long-Jiang Huang
Summary: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was developed, achieving a total yield of 34.5%, which is significantly higher than the previously reported process (11.0% total yield). The plausible ring-opening mechanism of the 6,19-epoxy bridge in compound 7 was proposed, and the structures of intermediates were confirmed by LC-MS analysis.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Yinchun Fang, Jianguo Wu, Guojie Ma, Qufu Wei
Summary: Polylactic acid (PLA) fibre is a renewable and biodegradable synthetic polymer that has gained attention in textiles. However, its dyeing process faces challenges, and a waterless dyeing method using disperse dyes is being explored as an alternative. This study investigated the waterless dyeing of PLA fibre using different disperse dyes and decamethylcyclopentasiloxane (D5) as the medium. Optimal dyeing process conditions were determined, and it was found that disperse dyes with a monoazo structure were most suitable for PLA waterless dyeing. The research provides a basis for developing suitable dyes for waterless dyeing of PLA using D5.
COLORATION TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yuanrong Li, Jianguo Wu, Chuanjiang He, Honghui He, Mingjun Xie, Ke Yao, Jing He, Yan Duan, Liujing Zhaung, Ping Wang, Yong He
Summary: Many mammalian tissues have specific cellular arrangements under stress stimulus, but conventional 3D encapsulation fails to replicate these arrangements accurately, so advanced cellular arrangement approaches are needed. In this study, a novel 3D prestress bioprinting approach is developed, using static sustained tensile stress, molecular chain orientation, and slow crosslinking in bioink to guide tissue construction. The semi-crosslinking state of the bioink provides excellent elasticity for applying stress on cells during the printing process. After printing, the bioink gradually crosslinks and maintains the applied stress force to induce cell-orientated growth. This approach allows for directional arrangement of multiple cell types, with adjustable internal stress in the hydrogel filament, and has potential applications in engineering skeletal muscles, tendons, ligaments, vascular networks, or combinations thereof.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Industrial
Ruiyu Xu, Song Huang, Zheren Song, Yuanyuan Gao, Jianguo Wu
Summary: This article proposes a deep mixed-effects modeling approach for anomaly detection in additive manufacturing. It captures the relationship between the melt pool temperature and other sensing data using a deep neural network, and incorporates random-effect and residual terms to account for variations and autocorrelations. Control charts based on T2 and generalized likelihood ratio statistics are developed for online monitoring.
Article
Environmental Sciences
Guanghui Zhao, Taihu Sun, Dongqi Wang, Shu Chen, Yan Ding, Yilan Li, Guitao Shi, Hechen Sun, Shengnan Wu, Yizhe Li, Chenyang Wu, Yufang Li, Zhongjie Yu, Zhenlou Chen
Summary: This study used stable isotopes to investigate the sources and transformation processes of nitrate in Suzhou Creek. The results showed that treated wastewater, soil nitrogen, and nitrogen fertilizer were the main sources of nitrate in the river. Reducing nitrate concentrations in treated wastewater is crucial for addressing nitrogen pollution in urban rivers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Mathematics, Applied
Marco Tosato, Xue Zhang, Jianhong Wu
Summary: We investigate the behavior of solutions to a scalar Delay Differential Equation (DDE) with periodic switching between two constant values. This equation naturally arises in structured vector populations involved in the spread of various vector-borne diseases in a periodically changing environment. We examine the influence of two different time lags and the switching time on the existence and patterns of periodic solutions, with a specific focus on multi-cycles within the prime period.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)