Molecular structure and function of big calcium-activated potassium channels in skeletal muscle: pharmacological perspectives

Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels

(2016) Julia Illison et al.   DIABETES

Randomized, placebo-controlled trials of dichlorphenamide in periodic paralysis

(2016) Valeria A. Sansone et al.   NEUROLOGY

Unoprostone activation of BK (K Ca 1.1) channel splice variants

(2015) Ling Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment

(2015) Timothy I. Webb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial BKCa channel

(2015) Enrique Balderas et al.   Frontiers in Physiology

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

(2014) Antonietta Mele et al.   BIOCHEMICAL PHARMACOLOGY

LRRC26 Is a Functional BK Channel Auxiliary γ Subunit in Arterial Smooth Muscle Cells

(2014) Kirk W. Evanson et al.   CIRCULATION RESEARCH

Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels

(2014) Subhrangsu Roy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats

(2014) José M. La Fuente et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The COPD pipeline

(2014) Yasser Mushtaq   NATURE REVIEWS DRUG DISCOVERY

Inhalation of the BKCa-Opener NS1619 Attenuates Right Ventricular Pressure and Improves Oxygenation in the Rat Monocrotaline Model of Pulmonary Hypertension

(2014) Marc Revermann et al.   PLoS One

Cysteine String Protein Limits Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel

(2014) Eva Ahrendt et al.   PLoS One

The large conductance Ca2+ -activated K+ (BKCa) channel regulates cell proliferation in SH-SY5Y neuroblastoma cells by activating the staurosporine-sensitive protein kinases

(2014) Angela Curci et al.   Frontiers in Physiology

BK channel activators and their therapeutic perspectives

(2014) Bo H. Bentzen et al.   Frontiers in Physiology

The regulation of BK channel activity by pre- and post-translational modifications

(2014) Barry D. Kyle et al.   Frontiers in Physiology

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

(2013) Sabata Pierno et al.   AGE

DiBAC4(3) hits a “sweet spot” for the activation of arterial large-conductance Ca2+-activated potassium channels independently of the β1-subunit

(2013) Fabiana S. Scornik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A BK (Slo1) channel journey from molecule to physiology

(2013) Gustavo F Contreras et al.   Channels

Molecular heterogeneity of large-conductance calcium-activated potassium channels in canine intracardiac ganglia

(2013) Elisabet Selga et al.   Channels

Phosphorylation of a constitutive serine inhibits BK channel variants containing the alternate exon “SRKR”

(2013) Chris Shelley et al.   JOURNAL OF GENERAL PHYSIOLOGY

A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid

(2013) Toshinori Hoshi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Emerging Role of Calcium-Activated Potassium Channel in the Regulation of Cell Viability Following Potassium Ions Challenge in HEK293 Cells and Pharmacological Modulation

(2013) Domenico Tricarico et al.   PLoS One

Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity

(2013) Giulia Maria Camerino et al.   PLoS One

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA

(2013) T. Hoshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+(BK) Channel Modulators: The GoSlo-SR Family

(2012) Subhrangsu Roy et al.   ChemMedChem

Glioma Big Potassium Channel Expression in Human Cancers and Possible T Cell Epitopes for Their Immunotherapy

(2012) L. Ge et al.   JOURNAL OF IMMUNOLOGY

Intracellular BKCa(iBKCa) channels

(2012) Harpreet Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Opening/blocking actions of pyruvate kinase antibodies on neuronal and muscular KATP channels

(2012) Antonietta Mele et al.   PHARMACOLOGICAL RESEARCH

Activation of BKCa Channels in Zoledronic Acid-Induced Apoptosis of MDA-MB-231 Breast Cancer Cells

(2012) Yu-Guang Ma et al.   PLoS One

Splicing of the rSlo Gene Affects the Molecular Composition and Drug Response of Ca2+-Activated K+ Channels in Skeletal Muscle

(2012) Maria Maddalena Dinardo et al.   PLoS One

BK potassium channel modulation by leucine-rich repeat-containing proteins

(2012) J. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function

(2011) Kiril L. Hristov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting BK (big potassium) channels in epilepsy

(2011) Prosper N'Gouemo   EXPERT OPINION ON THERAPEUTIC TARGETS

Acetazolamide efficacy in hypokalemic periodic paralysis and the predictive role of genotype

(2011) E. Matthews et al.   NEUROLOGY

Recent Advances in the Pathogenesis and Drug Action in Periodic Paralyses and Related Channelopathies

(2011) Domenico Tricarico et al.   Frontiers in Pharmacology

Muscle channelopathies: does the predicted channel gating pore offer new treatment insights for hypokalaemic periodic paralysis?

(2010) E. Matthews et al.   JOURNAL OF PHYSIOLOGY-LONDON

The KATPchannel is a molecular sensor of atrophy in skeletal muscle

(2010) Domenico Tricarico et al.   JOURNAL OF PHYSIOLOGY-LONDON

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

(2010) Jiusheng Yan et al.   NATURE

Calcium-Activated Potassium Channels BK and IK1 Are Functionally Expressed in Human Gliomas but Do Not Regulate Cell Proliferation

(2010) Iskandar F. Abdullaev et al.   PLoS One

BK channel activation: structural and functional insights

(2010) Urvi S. Lee et al.   TRENDS IN NEUROSCIENCES

Role of KCNMA1gene in breast cancer invasion and metastasis to brain

(2009) Divya Khaitan et al.   BMC CANCER

Immediate neuronal preconditioning by NS1619

(2009) Tamás Gáspár et al.   BRAIN RESEARCH

Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice

(2009) G E Koehl et al.   ONCOGENE

Modulation of BKCa Channel Gating by Endogenous Signaling Molecules

(2009) Shangwei Hou et al.   PHYSIOLOGY

K+-dependent paradoxical membrane depolarization and Na+ overload, major and reversible contributors to weakness by ion channel leaks

(2009) K. Jurkat-Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?

(2009) Federico Sesti et al.   TRENDS IN CELL BIOLOGY

Convergent Evolution of Alternative Splices at Domain Boundaries of the BK Channel

(2008) Anthony A. Fodor et al.   Annual Review of Physiology

The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells

(2008) Xiaobing Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential expression of BK channel isoforms and β-subunits in rat neuro-vascular tissues

(2008) Asser Nyander Poulsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Acetazolamide prevents vacuolar myopathy in skeletal muscle of K+-depleted rats

(2008) D Tricarico et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Unexpected Role for Ion Channels in Brain Tumor Metastasis

(2008) Harald Sontheimer   EXPERIMENTAL BIOLOGY AND MEDICINE

An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity

(2008) Max A. Seibold et al.   HUMAN MOLECULAR GENETICS

Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis

(2008) Béatrice Cambien et al.   INTERNATIONAL JOURNAL OF CANCER

Genetic variation in the KCNMA1 potassium channel α subunit as risk factor for severe essential hypertension and myocardial infarction

(2008) Marta Tomás et al.   JOURNAL OF HYPERTENSION

The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes

(2008) Trine Nielsen et al.   JOURNAL OF HYPERTENSION

Profiling the Phospho-status of the BKCaChannel α Subunit in Rat Brain Reveals Unexpected Patterns and Complexity

(2008) Jiusheng Yan et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular Determinants for the Activating/Blocking Actions of the 2H-1,4-Benzoxazine Derivatives, a Class of Potassium Channel Modulators Targeting the Skeletal Muscle KATP Channels

(2008) D. Tricarico et al.   MOLECULAR PHARMACOLOGY

Posttranscriptional Regulation of BK Channel Splice Variant Stability by miR-9 Underlies Neuroadaptation to Alcohol

(2008) Andrzej Z. Pietrzykowski et al.   NEURON

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats

(2007) Domenico Tricarico et al.   NEUROMUSCULAR DISORDERS