Targeting BK (big potassium) channels in epilepsy

Metal-driven Operation of the Human Large-conductance Voltage- and Ca2+-dependent Potassium Channel (BK) Gating Ring Apparatus

(2011) Anoosh D. Javaherian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mutually exclusive alternative exon ofslo1 codes for a neuronal BK channel with altered function

(2010) Malle Soom et al.   Channels

Location of modulatory β subunits in BK potassium channels

(2010) Guoxia Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical and hippocampal nerve terminals

(2010) Maria Martire et al.   JOURNAL OF NEUROCHEMISTRY

Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

(2010) Yunkun Wu et al.   NATURE

LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium

(2010) Jiusheng Yan et al.   NATURE

An Epilepsy/Dyskinesia-Associated Mutation Enhances BK Channel Activation by Potentiating Ca2+ Sensing

(2010) Junqiu Yang et al.   NEURON

Functional expression of large-conductance Ca2+-activated potassium channels in lateral globus pallidus neurons

(2010) X. Song et al.   NEUROSCIENCE

Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neurons

(2010) W.A. Kaufmann et al.   NEUROSCIENCE

Upregulation of STREX splice variant of the large conductance Ca2+-activated potassium (BK) channel in a rat model of mesial temporal lobe epilepsy

(2010) Boris S. Ermolinsky et al.   NEUROSCIENCE RESEARCH

Ca2+-Activated K+ Channels: From Protein Complexes to Function

(2010) Henrike Berkefeld et al.   PHYSIOLOGICAL REVIEWS

Ion sensing in the RCK1 domain of BK channels

(2010) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role of protein kinase C on BK channel regulation

(2010) Xiao-Bo Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat

(2009) Prosper N'Gouemo et al.   BRAIN RESEARCH

Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels

(2009) WR Sones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial involvement in temporal lobe epilepsy

(2009) Alexei P. Kudin et al.   EXPERIMENTAL NEUROLOGY

Calcium Ions Regulate K+ Uptake into Brain Mitochondria: The Evidence for a Novel Potassium Channel

(2009) Jolanta Skalska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intersubunit Coupling in the Pore of BK Channels

(2009) Ying Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zn2+Activates Large Conductance Ca2+-activated K+Channel via an Intracellular Domain

(2009) Shangwei Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Increased BK Channel Activation from a Channel Mutation that Causes Epilepsy

(2009) Bin Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

β subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia

(2009) Urvi S. Lee et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy

(2009) Liguo Wang et al.   NATURE

Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats

(2009) Boris Ermolinsky et al.   NEUROREPORT

Functional expression of a large-conductance Ca2+-activated K+ channel in mouse substantia nigra pars compacta dopaminergic neurons

(2009) Wenting Su et al.   NEUROSCIENCE LETTERS

Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy

(2008) Luis F. Pacheco Otalora et al.   BRAIN RESEARCH

Anticonvulsant effects of the BK-channel antagonist paxilline

(2008) Jesse J. Sheehan et al.   EPILEPSIA

Ethanol Modulates BKCa Channels by Acting as an Adjuvant of Calcium

(2008) J. Liu et al.   MOLECULAR PHARMACOLOGY

Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains

(2008) Huanghe Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain

(2008) Shangwei Hou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons

(2008) Sonal Shruti et al.   NEUROBIOLOGY OF DISEASE

KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes

(2008) B. A. Neubauer et al.   NEUROLOGY

Differential distribution of Ca2+-activated potassium channel β4 subunit in rat brain: Immunolocalization in neuronal mitochondria

(2008) M. Piwonska et al.   NEUROSCIENCE

17β-Estradiol at Physiological Concentrations Augments Ca2+-Activated K+Currents via Estrogen Receptor β in the Gonadotropin-Releasing Hormone Neuronal Cell Line GT1-7

(2007) Ichiro Nishimura et al.   ENDOCRINOLOGY

Modulation of hSlo BK current inactivation by fatty acid esters of CoA

(2007) Xiaolu Sun et al.   JOURNAL OF NEUROCHEMISTRY