Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

(2016) Takaya Moriyama et al.   NATURE GENETICS

Susceptibility to 6-MP toxicity conferred by aNUDT15variant in Japanese children with acute lymphoblastic leukaemia

(2015) Yoichi Tanaka et al.   BRITISH JOURNAL OF HAEMATOLOGY

NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia

(2015) K. Chiengthong et al.   HAEMATOLOGICA

InheritedNUDT15Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

(2015) Jun J. Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Influence ofSLCO1B1polymorphism on maintenance therapy for childhood leukemia

(2015) Ryoko Suzuki et al.   PEDIATRICS INTERNATIONAL

Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients

(2015) Mohammad Salem Hareedy et al.   PHARMACOGENOMICS

NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia

(2015) D-C Liang et al.   PHARMACOGENOMICS JOURNAL

NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia

(2015) K. Chiengthong et al.   HAEMATOLOGICA

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

(2014) Suk-Kyun Yang et al.   NATURE GENETICS

Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia

(2014) Y Tanaka et al.   PHARMACOGENOMICS JOURNAL

Incorporation of 6-Thioguanine Nucleotides into DNA During Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia-The Influence of Thiopurine Methyltransferase Genotypes

(2013) Maria S. Ebbesen et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children

(2011) Yoichi Tanaka et al.   LEUKEMIA RESEARCH

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

(2010) Hiromistu Ban et al.   JOURNAL OF GASTROENTEROLOGY

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

(2008) P. Krishnamurthy et al.   CANCER RESEARCH

Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group Study L99-15

(2008) A. Manabe et al.   HAEMATOLOGICA