Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia

Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4

(2013) Azza A.K. El-Sheikh et al.   Translational Research

Polymorphisms in the methotrexate transport pathway

(2012) Elixabet Lopez-Lopez et al.   Pharmacogenetics and Genomics

The activity of the inosine triphosphate pyrophosphatase affects toxicity of 6-mercaptopurine during maintenance therapy for acute lymphoblastic leukemia in Japanese children

(2011) Yoichi Tanaka et al.   LEUKEMIA RESEARCH

Thiopurine S-methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6-mercaptopurine doses during maintenance therapy: The Polish multicenter analysis

(2011) Jarosław Peregud-Pogorzelski et al.   PEDIATRIC BLOOD & CANCER

Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy

(2010) Tiphaine Adam de Beaumais et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease

(2010) O. Pozler et al.   Journal of Crohns & Colitis

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

(2010) Hiromistu Ban et al.   JOURNAL OF GASTROENTEROLOGY

Drug transporter pharmacogenetics in nucleoside-based therapies

(2010) Ekaitz Errasti-Murugarren et al.   PHARMACOGENOMICS

Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia

(2009) M. Ansari et al.   BLOOD

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

(2008) P. Krishnamurthy et al.   CANCER RESEARCH

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

(2008) G Stocco et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group Study L99-15

(2008) A. Manabe et al.   HAEMATOLOGICA

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4

(2008) Daniel Janke et al.   HUMAN MUTATION

The Human Multidrug Resistance Protein 4 (MRP4, ABCC4): Functional Analysis of a Highly Polymorphic Gene

(2008) N. Abla et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR gene, predisposes to 6-MP related toxicities in childhood ALL patients

(2008) N Karas-Kuzelicki et al.   LEUKEMIA

Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine

(2007) Xing-Xiang Peng et al.   LEUKEMIA RESEARCH