An enhancer haplotype may influence BCL11A expression levels and the response to hydroxyurea in β-thalassemia patients
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Title
An enhancer haplotype may influence BCL11A expression levels and the response to hydroxyurea in β-thalassemia patients
Authors
Keywords
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Journal
PHARMACOGENOMICS
Volume 18, Issue 10, Pages 995-967
Publisher
Future Medicine Ltd
Online
2017-06-22
DOI
10.2217/pgs-2017-0019
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Note: Only part of the references are listed.- Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells
- (2016) Qiupeng Zheng et al. BIOTECHNIQUES
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- (2015) Alessia Finotti et al. EXPERIMENTAL HEMATOLOGY
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- (2015) Yu-Chi Chou et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2015) Yu Gyoung Tak et al. Epigenetics & Chromatin
- Red cells in post-genomic era: impact of personalized medicine in the treatment of anemias
- (2015) A. Iolascon et al. HAEMATOLOGICA
- Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1
- (2015) Amanda J. Grieco et al. PLoS One
- Induction of adult levels of -globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL
- (2014) K. Trakarnsanga et al. HAEMATOLOGICA
- Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells
- (2014) Matthew C. Canver et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs
- (2014) Katarzyna Duda et al. NUCLEIC ACIDS RESEARCH
- An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System
- (2014) Xiaoxiao Zhu et al. Scientific Reports
- Enhancer variants: evaluating functions in common disease
- (2014) Olivia Corradin et al. Genome Medicine
- Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?
- (2013) Mehdi Banan ANNALS OF HEMATOLOGY
- Clinical experience with fetal hemoglobin induction therapy in patients with -thalassemia
- (2013) K. M. Musallam et al. BLOOD
- Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
- (2013) S. W. Cho et al. GENOME RESEARCH
- To respond or not to respond to hydroxyurea in thalassemia: a matter of stress adaptation?
- (2013) A. Ronchi et al. HAEMATOLOGICA
- Utility Of The Multivariate Approach In Predicting β-Thalassemia Intermedia Or β-Thalassemia Major Types In Iranian Patients
- (2013) Mehdi Banan et al. HEMOGLOBIN
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- (2013) Emmanuelle Charpentier et al. NATURE
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- (2013) Seung Woo Cho et al. NATURE BIOTECHNOLOGY
- Cas9 as a versatile tool for engineering biology
- (2013) Prashant Mali et al. NATURE METHODS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level
- (2013) D. E. Bauer et al. SCIENCE
- Pathophysiology and Clinical Manifestations of the -Thalassemias
- (2013) A. W. Nienhuis et al. Cold Spring Harbor Perspectives in Medicine
- Reawakening fetal hemoglobin: prospects for new therapies for the -globin disorders
- (2012) D. E. Bauer et al. BLOOD
- cAMP response element-binding protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells
- (2012) Mehdi Banan et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Hydroxyurea responsiveness in -thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity
- (2012) F. Pourfarzad et al. HAEMATOLOGICA
- The XmnI andBCL11ASingle Nucleotide Polymorphisms May Help Predict Hydroxyurea Response in Iranian β-Thalassemia Patients
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- Gene expression analysis of human red blood cells
- (2012) Sveta Kabanova et al. International Journal of Medical Sciences
- Enhancers and silencers: an integrated and simple model for their function
- (2012) Petros Kolovos et al. Epigenetics & Chromatin
- MBD2 contributes to developmental silencing of the human ε-globin gene
- (2011) Jeremy W. Rupon et al. BLOOD CELLS MOLECULES AND DISEASES
- Thalassaemia
- (2011) Douglas R Higgs et al. LANCET
- Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus
- (2010) Kiran Jawaid et al. BLOOD CELLS MOLECULES AND DISEASES
- Transcriptional silencing of -globin by BCL11A involves long-range interactions and cooperation with SOX6
- (2010) J. Xu et al. GENES & DEVELOPMENT
- BCL11A represses HBG transcription in K562 cells
- (2009) Zhiyi Chen et al. BLOOD CELLS MOLECULES AND DISEASES
- Control of fetal hemoglobin: new insights emerging from genomics and clinical implications
- (2009) S. L. Thein et al. HUMAN MOLECULAR GENETICS
- Copy number variants, diseases and gene expression
- (2009) C. N. Henrichsen et al. HUMAN MOLECULAR GENETICS
- A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger
- (2008) Rodwell Mabaera et al. EXPERIMENTAL HEMATOLOGY
- Genetic complexity in sickle cell disease
- (2008) D. R. Higgs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A
- (2008) Vijay G. Sankaran et al. SCIENCE
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