Reawakening fetal hemoglobin: prospects for new therapies for the  -globin disorders

Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation

(2012) Biaoru Li et al.   BMC GENOMICS

Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development

(2012) A. John et al.   DEVELOPMENT

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR

(2012) Jared J. Ganis et al.   DEVELOPMENTAL BIOLOGY

Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation

(2012) Kasey S. K. Chan et al.   FASEB JOURNAL

Genome editing in induced pluripotent stem cells

(2012) Li-Tao Cheng et al.   GENES TO CELLS

Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice

(2011) S. E. Meiler et al.   BLOOD

Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway

(2011) E. R. Macari et al.   BLOOD

A transient definitive erythroid lineage with unique regulation of the  -globin locus in the mammalian embryo

(2011) K. E. McGrath et al.   BLOOD

Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation

(2011) A. M. Pilon et al.   BLOOD

Proof of principle for transfusion of in vitro-generated red blood cells

(2011) M.-C. Giarratana et al.   BLOOD

KLF1 gene mutations cause borderline HbA2

(2011) L. Perseu et al.   BLOOD

A pilot study of subcutaneous decitabine in  -thalassemia intermedia

(2011) N. F. Olivieri et al.   BLOOD

Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease

(2011) J. Zou et al.   BLOOD

Zebrafish as a model for normal and malignant hematopoiesis

(2011) L. Jing et al.   Disease Models & Mechanisms

Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line

(2011) Sima Zein et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

(2011) S. Satta et al.   HAEMATOLOGICA

Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study

(2011) Kurt A Langberg et al.   JOURNAL OF HUMAN GENETICS

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

A Functional Element Necessary for Fetal Hemoglobin Silencing

(2011) Vijay G. Sankaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

(2011) V. G. Sankaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

(2011) J. Xu et al.   SCIENCE

A Dominant Mutation in the Gene Encoding the Erythroid Transcription Factor KLF1 Causes a Congenital Dyserythropoietic Anemia

(2010) Lionel Arnaud et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fetal globin gene inducers: novel agents and new potential

(2010) Susan P. Perrine et al.   Annals of the New York Academy of Sciences

Therapeutic levels of fetal hemoglobin in erythroid progeny of  -thalassemic CD34+ cells after lentiviral vector-mediated gene transfer

(2010) A. Wilber et al.   BLOOD

Globin phenotype of erythroid cells derived from human induced pluripotent stem cells

(2010) K.-H. Chang et al.   BLOOD

The inherited diseases of hemoglobin are an emerging global health burden

(2010) D. J. Weatherall   BLOOD

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

(2010) G. Rank et al.   BLOOD

Fetal globin expression is regulated by Friend of Prmt1

(2010) T. B. van Dijk et al.   BLOOD

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

(2010) E. Bianchi et al.   BLOOD

A complex task? Direct modulation of transcription factors with small molecules

(2010) Angela N Koehler   CURRENT OPINION IN CHEMICAL BIOLOGY

Transcriptional silencing of  -globin by BCL11A involves long-range interactions and cooperation with SOX6

(2010) J. Xu et al.   GENES & DEVELOPMENT

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

(2010) M. R. Tallack et al.   GENOME RESEARCH

Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease

(2010) M. Andreani et al.   HAEMATOLOGICA

The majority of the in vitro erythroid expansion potential resides in CD34- cells, outweighing the contribution of CD34+ cells and significantly increasing the erythroblast yield from peripheral blood samples

(2010) E. van den Akker et al.   HAEMATOLOGICA

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

(2010) H. Lapillonne et al.   HAEMATOLOGICA

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

(2010) Eirini P Papapetrou et al.   NATURE BIOTECHNOLOGY

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

(2010) Joseph Borg et al.   NATURE GENETICS

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor

(2010) M. Siatecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

The cost of health care for children and adults with sickle cell disease

(2009) Teresa L. Kauf et al.   AMERICAN JOURNAL OF HEMATOLOGY

Cytokine-mediated increases in fetal hemoglobin are associated with globin gene histone modification and transcription factor reprogramming

(2009) O. Sripichai et al.   BLOOD

SCF induces  -globin gene expression by regulating downstream transcription factor COUP-TFII

(2009) W. Aerbajinai et al.   BLOOD

Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study

(2009) A. T. Taher et al.   BLOOD

Transcriptional activation of the γ-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms

(2009) Janet Chin et al.   EXPERIMENTAL HEMATOLOGY

A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E

(2009) Manit Nuinoon et al.   HUMAN GENETICS

Developmental and species-divergent globin switching are driven by BCL11A

(2009) Vijay G. Sankaran et al.   NATURE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype

(2008) B. K. Singleton et al.   BLOOD

BCL11A is a major HbF quantitative trait locus in three different populations with β-hemoglobinopathies

(2008) Amanda E. Sedgewick et al.   BLOOD CELLS MOLECULES AND DISEASES

Global epidemiology of haemoglobin disorders and derived service indicators

(2008) Bernadette Modell   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Joining the loops: β-Globin gene regulation

(2008) Daan Noordermeer et al.   IUBMB LIFE

Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells

(2008) Laure A. Moutouh-de Parseval et al.   JOURNAL OF CLINICAL INVESTIGATION

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS

Hydroxyurea for the Treatment of Sickle Cell Anemia

(2008) Orah S. Platt   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of  -thalassemia

(2008) M. Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis

(2008) F. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymorphisms at the BCL11A, HBS1L-MYB, and  -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

(2008) G. Lettre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE