Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Optimizing the Bioavailability of Subcutaneously Administered Biotherapeutics Through Mechanochemical Drivers
Authors
Keywords
biodistribution, biologics, drug delivery, lymphatics, subcutaneous
Journal
PHARMACEUTICAL RESEARCH
Volume 34, Issue 10, Pages 2000-2011
Publisher
Springer Nature
Online
2017-07-14
DOI
10.1007/s11095-017-2229-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Aging and adipose tissue: potential interventions for diabetes and regenerative medicine
- (2016) Allyson K. Palmer et al. EXPERIMENTAL GERONTOLOGY
- Self-administered hyaluronidase-facilitated subcutaneous immunoglobulin therapy in complicated primary antibody deficiencies
- (2016) Maria Giovanna Danieli et al. Immunotherapy
- The pathology of the foreign body reaction against biomaterials
- (2016) R. Klopfleisch et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Switching Patients to Home-Based Subcutaneous Immunoglobulin: an Economic Evaluation of an Interprofessional Drug Therapy Management Program
- (2016) Clemence Perraudin et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Long-Term Tolerability, Safety, and Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Human Immunoglobulin for Primary Immunodeficiency
- (2016) Richard L. Wasserman et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Relating Protein–Protein Interactions and Aggregation Rates From Low to High Concentrations
- (2016) Ranendu Ghosh et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure
- (2016) Chi-Kin Chow et al. MOLECULAR PHARMACEUTICS
- Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling Subcutaneous Drug Administration
- (2015) Sanna Rosengren et al. AAPS Journal
- Tolerability of High-Volume Subcutaneous Injections of a Viscous Placebo Buffer: A Randomized, Crossover Study in Healthy Subjects
- (2015) Clapton Dias et al. AAPS PHARMSCITECH
- Hyaluronidase Caveats in Treating Filler Complications
- (2015) Marina Landau DERMATOLOGIC SURGERY
- A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components
- (2015) Hanne M. Kinnunen et al. JOURNAL OF CONTROLLED RELEASE
- Comparative Study of Analytical Techniques for Determining Protein Charge
- (2015) Dana I. Filoti et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Anatomical, Physiological, and Experimental Factors Affecting the Bioavailability of sc-Administered Large Biotherapeutics
- (2015) Anas M. Fathallah et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance after Subcutaneous Administration
- (2015) Linda J. Chan et al. MOLECULAR PHARMACEUTICS
- Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions
- (2015) Mariya Pindrus et al. MOLECULAR PHARMACEUTICS
- From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
- (2015) Natalie L. Trevaskis et al. NATURE REVIEWS DRUG DISCOVERY
- Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
- (2015) Giovanna Scapin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Defining the Lymphatic System of the Anterior Abdominal Wall
- (2015) Tali Friedman et al. PLASTIC AND RECONSTRUCTIVE SURGERY
- Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab
- (2015) Giovanna Scapin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Use of Transcutaneous Ultrasound for Lipolysis and Skin Tightening: A Review
- (2014) Lindsay R. Sklar et al. AESTHETIC PLASTIC SURGERY
- Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration
- (2014) Anas M. Fathallah et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Tolerability and Pharmacokinetic Properties of Ondansetron Administered Subcutaneously With Recombinant Human Hyaluronidase in Minipigs and Healthy Volunteers
- (2014) Samuel S. Dychter et al. CLINICAL THERAPEUTICS
- Subcutaneous Administration of Monoclonal Antibodies in Oncology
- (2014) C. Jackisch et al. GEBURTSHILFE UND FRAUENHEILKUNDE
- Comparison of Subcutaneous Versus Intravenous Administration of Rituximab As Maintenance Treatment for Follicular Lymphoma: Results From a Two-Stage, Phase IB Study
- (2014) Antonio Salar et al. JOURNAL OF CLINICAL ONCOLOGY
- Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site
- (2014) Hanne M. Kinnunen et al. JOURNAL OF CONTROLLED RELEASE
- Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging
- (2014) Livia S. Eberlin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Role of Electrostatics in Protein–Protein Interactions of a Monoclonal Antibody
- (2014) D. Roberts et al. MOLECULAR PHARMACEUTICS
- Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
- (2014) Sung-Youl Ko et al. NATURE
- Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties
- (2014) Li Li et al. PHARMACEUTICAL RESEARCH
- Model Study of the Pressure Build-Up during Subcutaneous Injection
- (2014) Maria Thomsen et al. PLoS One
- Therapeutic protein aggregation: mechanisms, design, and control
- (2014) Christopher J. Roberts TRENDS IN BIOTECHNOLOGY
- The mechanical properties of human adipose tissues and their relationships to the structure and composition of the extracellular matrix
- (2013) Nadia Alkhouli et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Changes in Adipose Tissue Macrophages and T Cells During Aging
- (2013) Sanjay K. Garg et al. CRITICAL REVIEWS IN IMMUNOLOGY
- Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes
- (2013) H. Sacks et al. DIABETES
- Cellular control of connective tissue matrix tension
- (2013) Helene M. Langevin et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Preference for subcutaneous or intravenous administration of trastuzumab in patients with HER2-positive early breast cancer (PrefHer): an open-label randomised study
- (2013) Xavier Pivot et al. LANCET ONCOLOGY
- Characterization and Suitability of Therapeutic Antibody Dense Phases for Subcutaneous Delivery
- (2013) Harvey R. Johnson et al. MOLECULAR PHARMACEUTICS
- High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
- (2013) Xiao Tian et al. NATURE
- Effect of ultrasound on the aqueous viscosity of several water-soluble polymers
- (2013) Josue Addiel Venegas-Sanchez et al. POLYMER JOURNAL
- Ultrasound effect used as external stimulus for viscosity change of aqueous carrageenans
- (2013) Josue Addiel Venegas-Sanchez et al. ULTRASONICS SONOCHEMISTRY
- Porcine model to evaluate local tissue tolerability associated with subcutaneous delivery of protein
- (2013) D.W. Kang et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics
- (2012) Daniela Bumbaca et al. AAPS Journal
- A frustrating problem: Accelerated blood clearance of PEGylated solid lipid nanoparticles following subcutaneous injection in rats
- (2012) Yongxue Zhao et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I–III breast cancer (HannaH study): a phase 3, open-label, multicentre, randomised trial
- (2012) Gustavo Ismael et al. LANCET ONCOLOGY
- Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration
- (2012) Yanan Zheng et al. mAbs
- Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies
- (2012) Yi Du et al. mAbs
- Effect of PEGylation on Protein Hydrodynamics
- (2012) Yatin R. Gokarn et al. MOLECULAR PHARMACEUTICS
- The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions
- (2012) Sandeep Yadav et al. MOLECULAR PHARMACEUTICS
- Factors Influencing the Use and Interpretation of Animal Models in the Development of Parenteral Drug Delivery Systems
- (2011) Marilyn N. Martinez AAPS Journal
- Aggrecan, an unusual polyelectrolyte: Review of solution behavior and physiological implications
- (2011) Preethi L. Chandran et al. Acta Biomaterialia
- Deep penetration and liquid injection into adipose tissue
- (2011) Kerstyn Comley et al. Journal of Mechanics of Materials and Structures
- Viscosity Behavior of High-Concentration Monoclonal Antibody Solutions: Correlation with Interaction Parameter and Electroviscous Effects
- (2011) Sandeep Yadav et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Lymphatic anatomy and biomechanics
- (2011) Daniela Negrini et al. JOURNAL OF PHYSIOLOGY-LONDON
- Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions
- (2011) Yatin R. Gokarn et al. PROTEIN SCIENCE
- Layers of the abdominal wall: anatomical investigation of subcutaneous tissue and superficial fascia
- (2011) Luca Lancerotto et al. SURGICAL AND RADIOLOGIC ANATOMY
- Acide hyaluronique : structure, métabolisme et implication dans la cicatrisation
- (2010) Y. Gall ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
- Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics
- (2010) C. Andrew Boswell et al. BIOCONJUGATE CHEMISTRY
- Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody
- (2010) J. Paul Brandt et al. BIOPHYSICAL JOURNAL
- Microvascular fluid exchange and the revised Starling principle
- (2010) J. Rodney Levick et al. CARDIOVASCULAR RESEARCH
- Nonablative Radiofrequency for Skin Rejuvenation
- (2010) Mohamed L. Elsaie et al. DERMATOLOGIC SURGERY
- Dose-Dependent Delay of the Hypoglycemic Effect of Short-Acting Insulin Analogs in Obese Subjects With Type 2 Diabetes: A pharmacokinetic and pharmacodynamic study
- (2010) M. Gagnon-Auger et al. DIABETES CARE
- Minipig, minipig, let me in
- (2010) Elie Dolgin NATURE MEDICINE
- Microneedle-Based Intradermal Delivery Enables Rapid Lymphatic Uptake and Distribution of Protein Drugs
- (2010) Alfred J. Harvey et al. PHARMACEUTICAL RESEARCH
- Continuous kinematic wave models of merging traffic flow
- (2010) Wen-Long Jin TRANSPORTATION RESEARCH PART B-METHODOLOGICAL
- Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release
- (2009) R. D. Jayant et al. DRUG DELIVERY
- Comparison of Manual Lymph Drainage Therapy and Connective Tissue Massage in Women With Fibromyalgia: A Randomized Controlled Trial
- (2009) Gamze Ekici et al. JOURNAL OF MANIPULATIVE AND PHYSIOLOGICAL THERAPEUTICS
- Sonophoresis: recent advancements and future trends
- (2009) Rekha Rao et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Hyaluronidase in the correction of hyaluronic acid-based fillers: a review and a recommendation for use
- (2009) Berthold Rzany et al. Journal of Cosmetic Dermatology
- Interaction Between the Interstitial Fluid and the Extracellular Matrix in Confined Indentation
- (2008) Yiling Lu et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- Transdermal drug delivery
- (2008) Mark R Prausnitz et al. NATURE BIOTECHNOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started