Article
Gastroenterology & Hepatology
Sun-Ho Lee, Margaret Walshe, Eun Hye Oh, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Tomer Greener, Adam Weizman, Mark S. Silverberg, Byong Duk Ye
Summary: The study suggests that changes in serum albumin levels within the first 2 weeks of anti-TNF treatment can predict primary nonresponse, endoscopic outcomes, time to colectomy, and anti-TNF failure in patients with UC. Early access to this biomarker may help identify patients at risk of treatment failure and guide early optimization of anti-TNF therapy.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Kengo Kanayama, Jun Kato, Wataru Shiratori, Ariki Nagashima, Yuki Ohta, Takashi Taida, Keiko Saito, Chihiro Goto, Satsuki Takahashi, Ryosuke Horio, Akane Kurosugi, Tsubasa Ishikawa, Tatsuya Kaneko, Naoki Akizue, Kenichiro Okimoto, Tomoaki Matsumura, Naoya Kato
Summary: This study found that selecting subsequent treatment based on the response to initial anti-tumor necrosis factor (TNF)alpha antibody (ATA) is feasible in refractory ulcerative colitis (UC) patients. Non-ATA may be suitable as subsequent biologics for UC patients regardless of the efficacy of the first ATA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Guanglin Cui, Qingbo Fan, Zhenfeng Li, Rasmus Goll, Jon Florholmen
Summary: This review discusses the use of TNF antibodies in treating IBD and the evaluation of therapeutic efficacy using current and novel biomarkers. It emphasizes the urgent need for validation and comparison studies of promising novel biomarkers to improve their value in clinical practice.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Xinhui Yang, Jintong Shi, Gaoyang Wang, Huifang Chen, Youqiong Ye, Jie Zhong, Zhengting Wang
Summary: A new method for predicting the therapeutic efficacy of anti-tumor necrosis factor in ulcerative colitis patients was developed using a transcription signature score. The study also identified the associations between clinical features, immune microenvironment, and treatment response.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P. Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen G. C. McGregor, Tim Ambrose, Bruce D. George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P. L. Travis, Jack Satsangi
Summary: The changes in acute severe colitis (ASC) management have resulted in improved outcomes. A simple predictive model can be used to identify patients who will not respond to steroids upon admission.
Article
Gastroenterology & Hepatology
Alka A. Potdar, Shishir Dube, Takeo Naito, Katherine Li, Gregory Botwin, Talin Haritunians, Dalin Li, David Casero, Shaohong Yang, Janine Bilsborough, Jacqueline G. Perrigoue, Lee A. Denson, Mark Daly, Stephan R. Targan, Phillip Fleshner, Jonathan Braun, Subra Kugathasan, Thaddeus S. Stappenbeck, Dermot P. B. McGovern
Summary: The study identified differences in intestinal ACE2 expression levels in patients with Crohn's disease and ulcerative colitis, associated with inflammation and disease severity. Treatment with anti-cytokine therapy restored ACE2 expression, potentially impacting outcomes of severe acute respiratory syndrome coronavirus 2 infection.
Article
Microbiology
Jie Liu, Huaying Fang, Na Hong, Chaolan Lv, Qihua Zhu, Yinping Feng, Bo Wang, Jiashuang Tian, Yue Yu
Summary: Patients with ulcerative colitis (UC) have low response rates to anti-integrin medications in the latest VARSITY study. Our study aimed to identify differences in the gut microbiome and metabonomics patterns between early remission and nonremission patients, and to explore the diagnostic value in predicting clinical remission to anti-integrin therapy accurately. We found that Verrucomicrobiota, butyric acid, and isobutyric acid improved the diagnosis of early remission to anti-integrin therapy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Riccardo Capecchi, Paola Migliorini, Federico Zanzi, Simona Maltinti, Ilaria Puxeddu, Nicola de Bortoli, Massimo Bellini, Francesco Costa, Santino Marchi, Lorenzo Bertani
Summary: The study demonstrated a correlation between Ig glycosylation and disease activity in UC patients, suggesting a potential role for lectin-selected Ig in predicting therapeutic effectiveness. If confirmed, Ig glycosylation could serve as a biomarker in UC.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiangji Yan, Lingzhang Meng, Xingzhe Zhang, Zhichao Deng, Bowen Gao, Yujie Zhang, Mei Yang, Yana Ma, Yuanyuan Zhang, Kangsheng Tu, Mingzhen Zhang, Qiuran Xu
Summary: This study aims to develop a ROS-responsive and FA-functionalized nanoparticle for efficient PSB delivery to treat UC. The PSB@NP-FA exhibited ROS-scavenging properties and preferentially localized to the inflamed colon, effectively relieving murine colitis. Mechanism results showed that PSB@NP-FA regulated DCs, promoted macrophage polarization, and regulated T cell infiltration. Furthermore, the combination of PSB and DEX enhanced the therapeutic efficacy.
Article
Gastroenterology & Hepatology
Lujain Maasfeh, Anetta Hartlova, Stefan Isaksson, Johanna Sundin, Georgios Mavroudis, Otto Savolainen, Hans Strid, Lena Ohman, Maria K. Magnusson
Summary: Fecal luminal factors from healthy donors can down-regulate signaling pathways in macrophages and influence their function, while those from UC patients in remission have a weaker effect on macrophages. Metabolomic analysis revealed differential fecal metabolite composition between healthy individuals and UC patients in remission. This suggests that UC patients in remission may lack the necessary signals to condition macrophages towards a hyporesponsive and tolerogenic phenotype, making them vulnerable to relapse.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ji Tae Kim, Dana L. Napier, Jinhwan Kim, Chang Li, Eun Y. Lee, Heidi L. Weiss, Qingding Wang, B. Mark Evers
Summary: The disturbance of self-regeneration in mammalian intestinal epithelium is associated with intestinal disorders, particularly inflammatory bowel diseases (IBDs). TNF alpha inhibits ketone body production, but the exact role of ketogenesis in TNF alpha-mediated pathology is not fully understood. The study showed that HMGCS2, a key enzyme in ketogenesis, is downregulated by TNF alpha and plays a role in attenuating apoptosis and inflammation in intestinal epithelial cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Freddy Caldera, Francis A. Farraye, Brian M. Necela, Davitte Cogen, Sumona Saha, Arnold Wald, Nader D. Daoud, Kelly Chun, Ian Grimes, Megan Lutz, Sean R. Van Helden, Melanie D. Swift, Abinash Virk, Adil E. Bharucha, Tushar C. Patel, Gregory J. Gores, Saranya Chumsri, Mary S. Hayney, Keith L. Knutson
Summary: Most patients with inflammatory bowel disease achieve a cell-mediated immune response (CMIR) to mRNA COVID-19 vaccines, with no difference compared to healthy control subjects. There is no significant difference in CMIR between immunocompetent and immunosuppressed patients. There is no correlation between humoral and cell-mediated immunity after vaccination.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Cell Biology
Chunlan Huang, Qixiang Mei, Lihong Lou, Zehua Huang, Yang Fu, Junjie Fan, Jingjing Wang, Nuoming Yin, Yi Zheng, Yingying Lu, Yue Zeng
Summary: The colonization of Faecalibacterium after fecal microbiota transplantation plays a crucial role in the remission of ulcerative colitis by alleviating intestinal inflammation. This anti-inflammatory effect of Faecalibacterium may be achieved by regulating the imbalance of Th17/Treg levels in ulcerative colitis.
Review
Gastroenterology & Hepatology
Edo H. J. Savelkoul, Pepijn W. A. Thomas, Lauranne A. A. P. Derikx, Nathan den Broeder, Tessa E. H. Romkens, Frank Hoentjen
Summary: Loss of response to infliximab or adalimumab in ulcerative colitis occurs frequently, with an annual rate of 10% for infliximab and 13% for adalimumab. Dose escalation rates were higher than loss of response, with 72% and 52% regaining clinical benefit for infliximab and adalimumab, respectively. Uniform definitions are needed for more robust evaluations.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
M. K. Magnusson, S. F. Brynjolfsson, A. Dige, H. Uronen-Hansson, L. G. Borjesson, J. L. Bengtsson, S. Gudjonsson, L. Ohman, J. Agnholt, H. Sjovall, W. W. Agace, M. J. Wick
MUCOSAL IMMUNOLOGY
(2016)
Article
Nutrition & Dietetics
Nina Friis Bak, M. Bendix, S. Hald, L. Reinert, M. K. Magnusson, J. Agnholt
EUROPEAN JOURNAL OF NUTRITION
(2018)
Article
Gastroenterology & Hepatology
Maria K. Magnusson, Hans Strid, Stefan Isaksson, Magnus Simren, Lena Ohman
INFLAMMATORY BOWEL DISEASES
(2017)
Review
Gastroenterology & Hepatology
Bani Ahluwalia, Maria K. Magnusson, Lena Ohman
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2017)
Article
Cell Biology
Anders Dige, Maria K. Magnusson, Claus Uhrenholt, Tue Kruse Rasmussen, Tue Kragstrup, Lena Ohman, Jens Dahlerup, Jorgen Agnholt
MEDIATORS OF INFLAMMATION
(2018)
Review
Gastroenterology & Hepatology
Bani Ahluwalia, Luiza Moraes, Maria K. Magnusson, Lena Ohman
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2018)
Article
Multidisciplinary Sciences
Ana Cardeno, Maria K. Magnusson, Marianne Quiding-Jarbrink, Anna Lundgren
SCIENTIFIC REPORTS
(2018)
Article
Gastroenterology & Hepatology
Sean M. P. Bennet, Johanna Sundin, Maria K. Magnusson, Hans Strid, Julien Tap, Muriel Derrien, Boris Le Neve, Joel Dore, Hans Tornblom, Magnus Simren, Lena Ohman
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Cell Biology
Maria K. Magnusson, Stefan Isaksson, Lena Ohman
Article
Gastroenterology & Hepatology
Cristina Iribarren, Hans Tornblom, Imran Aziz, Maria K. Magnusson, Johanna Sundin, Louise K. Vigsnaes, Ingvild Dybdrodt Amundsen, Bruce McConnell, Dorthe Seitzberg, Lena Ohman, Magnus Simren
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Gastroenterology & Hepatology
Charles Caer, Frida Gorreja, Sophia K. Forsskahl, Siggeir F. Brynjolfsson, Louis Szeponik, Maria K. Magnusson, Lars G. Borjesson, Mattias Block, Elinor Bexe-Lindskog, Mary Jo Wick
Summary: The study showed that high expression of intestinal TREM-1 in IBD patients is associated with a high frequency of TREM-1(+) immature macrophages and TREM-1(+)CD11b(+) granulocytes, which contribute to the deleterious inflammatory microenvironment. Blocking the TREM-1 pathway, especially simultaneously with anti-TNF therapy, has potential as a new therapy for IBD.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Lujain Maasfeh, Anetta Hartlova, Stefan Isaksson, Johanna Sundin, Georgios Mavroudis, Otto Savolainen, Hans Strid, Lena Ohman, Maria K. Magnusson
Summary: Fecal luminal factors from healthy donors can down-regulate signaling pathways in macrophages and influence their function, while those from UC patients in remission have a weaker effect on macrophages. Metabolomic analysis revealed differential fecal metabolite composition between healthy individuals and UC patients in remission. This suggests that UC patients in remission may lack the necessary signals to condition macrophages towards a hyporesponsive and tolerogenic phenotype, making them vulnerable to relapse.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bani Ahluwalia, Maria K. Magnusson, Fredrik Larsson, Otto Savolainen, Alastair B. Ross, Lena Ohman
Summary: This study aimed to determine the metabolite composition of commercial Aloe extracts and assess their effects on human blood T cell activity. The results showed that different extracts had varying effects on T cells, including activation, proliferation, apoptosis, and cell death, which were related to the standard phytochemical composition of the extracts rather than the acemannan content.
Article
Biochemistry & Molecular Biology
Luiza Moraes Holst, Cristina Iribarren, Maria Sapnara, Otto Savolainen, Hans Tornblom, Yvonne Wettergren, Hans Strid, Magnus Simren, Maria K. Magnusson, Lena Ohman
Summary: This study analyzed the metabolite profiles of fecal supernatants from patients with colon cancer, ulcerative colitis, and irritable bowel syndrome, and investigated their effects on intestinal cells and colonoid cultures. The results showed that the fecal supernatants from different patient groups and healthy subjects altered the gene expression profiles of Caco-2 cells and colonoid cultures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Bani Ahluwalia, Maria K. Magnusson, Lena Bohn, Stine Storsrud, Fredrik Larsson, Lena Ohman, Magnus Simren
Summary: Aloe extract significantly improves symptom severity in IBS-D patients and increases the proportion of responders, but its effect on other IBS subtypes is not superior to control treatment.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)