Activated T follicular helper-like cells are released into blood after oral vaccination and correlate with vaccine specific mucosal B-cell memory

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

(2017) Antje Heit et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Correlates of protection for enteric vaccines

(2017) Jan Holmgren et al.   VACCINE

Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion

(2017) Mark A. Pilkinton et al.   VACCINE

Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infection

(2017) Laila N. Abudulai et al.   PLoS One

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Circulating HIV-Specific Interleukin-21 + CD4 + T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions

(2016) Bruce T. Schultz et al.   IMMUNITY

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique

(2016) Colin Havenar-Daughton et al.   JOURNAL OF IMMUNOLOGY

Induction of long term mucosal immunological memory in humans by an oral inactivated multivalent enterotoxigenic Escherichia coli vaccine

(2016) Anna Lundgren et al.   VACCINE

Circulating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccine

(2016) Fouzia Farooq et al.   Scientific Reports

ICOS+PD-1+CXCR3+ T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination

(2016) Salah-Eddine Bentebibel et al.   Scientific Reports

Advances in IL-21 biology—enhancing our understanding of human disease

(2015) Stuart G Tangye   CURRENT OPINION IN IMMUNOLOGY

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

(2015) Cindy S. Ma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Reversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV Infection

(2015) Rafael Cubas et al.   JOURNAL OF IMMUNOLOGY

Cholera Toxin, and the Related Nontoxic Adjuvants mmCT and dmLT, Promote Human Th17 Responses via Cyclic AMP–Protein Kinase A and Inflammasome-Dependent IL-1 Signaling

(2015) Maximilian Larena et al.   JOURNAL OF IMMUNOLOGY

Pathophysiology of T follicular helper cells in humans and mice

(2015) Hideki Ueno et al.   NATURE IMMUNOLOGY

Vaccines against enteric infections for the developing world

(2015) C. Czerkinsky et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Circulating CXCR5+CD4+ T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus Vaccines

(2015) Ken Matsui et al.   PLoS One

Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

(2015) Nyamekye Obeng-Adjei et al.   Cell Reports

Circulating T follicular regulatory and helper cells have memory-like properties

(2014) Peter T. Sage et al.   JOURNAL OF CLINICAL INVESTIGATION

Life of T Follicular Helper Cells

(2014) Woong-Kyung Suh   MOLECULES AND CELLS

Phenotype and functions of memory Tfh cells in human blood

(2014) Nathalie Schmitt et al.   TRENDS IN IMMUNOLOGY

Safety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I study

(2014) Anna Lundgren et al.   VACCINE

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

A Double Mutant Heat-Labile Toxin from Escherichia coli, LT(R192G/L211A), Is an Effective Mucosal Adjuvant for Vaccination against Helicobacter pylori Infection

(2013) Louise Sjökvist Ottsjö et al.   INFECTION AND IMMUNITY

Gain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survival

(2013) Neil Romberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection

(2013) S. Alam et al.   JOURNAL OF VIROLOGY

Enzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in blood

(2013) Giulietta Saletti et al.   Nature Protocols

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein

(2013) A. Lundgren et al.   VACCINE

Different kinetics of circulating antibody-secreting cell responses after primary and booster oral immunizations: A tool for assessing immunological memory

(2013) Susannah Leach et al.   VACCINE

Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant

(2013) J. Holmgren et al.   VACCINE

Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal and affinity-matured gut IgA responses

(2012) P Bergqvist et al.   Mucosal Immunology

The Adjuvant Double Mutant Escherichia coli Heat Labile Toxin Enhances IL-17A Production in Human T Cells Specific for Bacterial Vaccine Antigens

(2012) Susannah Leach et al.   PLoS One

Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets

(2011) Chuanwu Wang et al.   BMC IMMUNOLOGY

Characterization of a Mutant Escherichia coli Heat-Labile Toxin, LT(R192G/L211A), as a Safe and Effective Oral Adjuvant

(2011) Elizabeth B. Norton et al.   Clinical and Vaccine Immunology

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Function of Mucosa-Associated Lymphoid Tissue in Antibody Formation

(2010) Per Brandtzaeg   IMMUNOLOGICAL INVESTIGATIONS

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins

(2010) N Lycke et al.   Mucosal Immunology

The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells

(2010) C. M. Paulos et al.   Science Translational Medicine

Parallel analysis of mucosally derived B- and T-cell responses to an oral typhoid vaccine using simplified methods

(2009) Anna Lundgren et al.   VACCINE

Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: Comparison with other mucosal and systemic responses

(2009) Sohel Shamsuzzaman et al.   VACCINE