The Anti-inflammatory Immune Regulation Induced by Butyrate Is Impaired in Inflamed Intestinal Mucosa from Patients with Ulcerative Colitis

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis

(2019) Samuel P. Costello et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis

(2019) Maaike Vancamelbeke et al.   Journal of Crohns & Colitis

Mucosal and Systemic Immune Profiles Differ During Early and Late Phases of the Disease in Patients With Active Ulcerative Colitis

(2019) Georgios Mavroudis et al.   Journal of Crohns & Colitis

Intestinal Inflammation Modulates the Epithelial Response to Butyrate in Patients With Inflammatory Bowel Disease

(2019) Elena Ferrer-Picón et al.   INFLAMMATORY BOWEL DISEASES

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

(2018) Ye Zhao et al.   Mucosal Immunology

Systematic Review and Meta-analysis

(2017) Neeraj Narula et al.   INFLAMMATORY BOWEL DISEASES

Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner

(2017) Changhyun Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Microbial shifts and signatures of long-term remission in ulcerative colitis after faecal microbiota transplantation

(2017) Susana Fuentes et al.   ISME Journal

Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells

(2017) Claudia Nastasi et al.   Scientific Reports

Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway

(2017) Hui Yan et al.   PLoS One

Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity

(2017) Annelies Geirnaert et al.   Scientific Reports

Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats

(2016) Mingming Zhang et al.   BMC GASTROENTEROLOGY

An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis

(2016) Raffaele Simeoli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease

(2016) Kenichiro Takahashi et al.   DIGESTION

A decrease of the butyrate-producing speciesRoseburia hominisandFaecalibacterium prausnitziidefines dysbiosis in patients with ulcerative colitis

(2013) Kathleen Machiels et al.   GUT

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India

(2013) Reena Kumari   WORLD JOURNAL OF GASTROENTEROLOGY

Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells

(2012) Lu Liu et al.   CELLULAR IMMUNOLOGY

Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery

(2012) Ilaria Russo et al.   PLoS One

Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway*

(2011) Vicky De Preter et al.   INFLAMMATORY BOWEL DISEASES

The dietary histone deacetylase inhibitor sulforaphane induces human β-defensin-2 in intestinal epithelial cells

(2008) Markus Schwab et al.   IMMUNOLOGY