DNA methylation and its role in the pathogenesis of diabetes

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

(2016) Jinxiu Rui et al.   DIABETOLOGIA

Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression

(2016) V. K. Chaithanya Ponnaluri et al.   Epigenetics

Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins

(2016) Emon Elboudwarej et al.   JOURNAL OF AUTOIMMUNITY

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Role of DNA methylation at the placentalRTL1gene locus in type 1 diabetes

(2016) Marie-Pierre Belot et al.   PEDIATRIC DIABETES

Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences

(2016) Sebastian Moran et al.   Epigenomics

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

(2015) Marisa M. Fisher et al.   DIABETES

Gestational Diabetes Alters Offspring DNA Methylation Profiles in Human and Rat: Identification of Key Pathways Involved in Endocrine System Disorders, Insulin Signaling, Diabetes Signaling, and ILK Signaling

(2015) Sophie Petropoulos et al.   ENDOCRINOLOGY

Bisphenol A Exposure Disrupts Metabolic Health Across Multiple Generations in the Mouse

(2015) Martha Susiarjo et al.   ENDOCRINOLOGY

DNA Methylation Profiles in Placenta and Its Association with Gestational Diabetes Mellitus

(2015) C. Rong et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Maternal gestational diabetes is associated with genome-wide DNA methylation variation in placenta and cord blood of exposed offspring

(2015) Sarah Finer et al.   HUMAN MOLECULAR GENETICS

DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes

(2015) Tina Rönn et al.   Epigenomics

The Potential Use of DNA Methylation Biomarkers to Identify Risk and Progression of Type 2 Diabetes

(2015) Linn Gillberg et al.   Frontiers in Endocrinology

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

(2014) Maléne E Lindholm et al.   Epigenetics

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Genome-Wide Associations between Genetic and Epigenetic Variation Influence mRNA Expression and Insulin Secretion in Human Pancreatic Islets

(2014) Anders H. Olsson et al.   PLoS Genetics

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

(2013) Elin Hall et al.   BMC Medical Genetics

Economic Costs of Diabetes in the U.S. in 2012

(2013)   DIABETES CARE

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

(2013) T. A. Dayeh et al.   DIABETOLOGIA

Clinical presentation of 6q24 transient neonatal diabetes mellitus (6q24 TNDM) and genotype–phenotype correlation in an international cohort of patients

(2013) L. E. Docherty et al.   DIABETOLOGIA

Bridging epigenetics and metabolism

(2013) James M. Phang et al.   Epigenetics

DNA hypermethylation and DNA hypomethylation is present at different loci in chronic kidney disease

(2013) Laura J Smyth et al.   Epigenetics

DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology

(2013) Mihaela Stefan et al.   JOURNAL OF AUTOIMMUNITY

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

Bisphenol A Exposure Disrupts Genomic Imprinting in the Mouse

(2013) Martha Susiarjo et al.   PLoS Genetics

DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes

(2013) Dvir Aran et al.   GENOME BIOLOGY

Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms

(2012) Robert V. Intine et al.   Current Diabetes Reports

Metabolic Programming of MEST DNA Methylation by Intrauterine Exposure to Gestational Diabetes Mellitus

(2012) N. El Hajj et al.   DIABETES

Epigenetics in autoimmune diseases with focus on type 1 diabetes

(2012) Mary Ngoc Dang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Hypoglycaemia following diabetes remission in patients with 6q24 methylation defects: expanding the clinical phenotype

(2012) S. E. Flanagan et al.   DIABETOLOGIA

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

Dietary protein restriction and excess of pregnant German Landrace sows induce changes in hepatic gene expression and promoter methylation of key metabolic genes in the offspring

(2012) Simone Altmann et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Increased DNA Methylation and Decreased Expression ofPDX-1in Pancreatic Islets from Patients with Type 2 Diabetes

(2012) Beatrice T. Yang et al.   MOLECULAR ENDOCRINOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study

(2012) Roopa Kanakatti Shankar et al.   PEDIATRIC DIABETES

Development of a Quantitative Methylation-Specific Polymerase Chain Reaction Method for Monitoring Beta Cell Death in Type 1 Diabetes

(2012) Mohamed I. Husseiny et al.   PLoS One

An Unbiased Assessment of the Role of Imprinted Genes in an Intergenerational Model of Developmental Programming

(2012) Elizabeth J. Radford et al.   PLoS Genetics

Diagnosis and Classification of Diabetes Mellitus

(2011)   DIABETES CARE

Type 2 Diabetes in Youth: Epidemiology and Pathophysiology

(2011) E. D'Adamo et al.   DIABETES CARE

Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias

(2011) Shalima S. Nair et al.   Epigenetics

DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy

(2011) Carmen Sapienza et al.   Epigenetics

Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome

(2011) Céline Jousse et al.   FASEB JOURNAL

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

(2011) Hongcang Gu et al.   Nature Protocols

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

(2011) I. Sandovici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of   cell death in diabetes using differentially methylated circulating DNA

(2011) E. M. Akirav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the Infinium Methylation 450K technology

(2011) Sarah Dedeurwaerder et al.   Epigenomics

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

(2011) Vardhman K. Rakyan et al.   PLoS Genetics

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

(2010) Dandan Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus

(2010) Christopher G Bell et al.   BMC Medical Genomics

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

(2010) B. T. Yang et al.   DIABETOLOGIA

DNA methylation profiling in cell models of diabetic nephropathy

(2010) Eoin P. Brennan et al.   Epigenetics

Replication timing-related and gene body-specific methylation of active human genes

(2010) Dvir Aran et al.   HUMAN MOLECULAR GENETICS

Experimental Intrauterine Growth Restriction Induces Alterations in DNA Methylation and Gene Expression in Pancreatic Islets of Rats

(2010) Reid F. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Targets and dynamics of promoter DNA methylation during early mouse development

(2010) Julie Borgel et al.   NATURE GENETICS

Genome-scale DNA methylation analysis

(2010) Shaun D Fouse et al.   Epigenomics

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction

(2009) Esther M. E. van Straten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

(2009) Romain Barrès et al.   Cell Metabolism

Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes

(2009) Charlotte Ling et al.   DIABETES

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

(2009) Madeleine P Ball et al.   NATURE BIOTECHNOLOGY

Rethinking how DNA methylation patterns are maintained

(2009) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring

(2008) Karen A. Lillycrop et al.   BRITISH JOURNAL OF NUTRITION

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

Genome-scale DNA methylation maps of pluripotent and differentiated cells

(2008) Alexander Meissner et al.   NATURE

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

(2008) Shawn J. Cokus et al.   NATURE