Mechanisms of naturally acquired immunity to P. falciparum and approaches to identify merozoite antigen targets

Emerging concepts in T follicular helper cell responses to malaria

(2017) Diana S. Hansen et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

(2017) Lin Chen et al.   eLife

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody

(2017) Paola Favuzza et al.   eLife

Malaria: Biology and Disease

(2016) Alan F. Cowman et al.   CELL

Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes

(2016) Jennifer C. Volz et al.   Cell Host & Microbe

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

(2016) Arnaud M. Didierlaurent et al.   Expert Review of Vaccines

Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children

(2016) Linda M. Murungi et al.   INFECTION AND IMMUNITY

MultiplePlasmodium falciparumMerozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes

(2016) Clara S. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Regions ofPlasmodium falciparumErythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy

(2016) Chris Y. Chiu et al.   JOURNAL OF INFECTIOUS DISEASES

Examining cellular immune responses to inform development of a blood-stage malaria vaccine

(2016) DANIELLE I. STANISIC et al.   PARASITOLOGY

Immunological processes underlying the slow acquisition of humoral immunity to malaria

(2016) VICTORIA RYG-CORNEJO et al.   PARASITOLOGY

Overlaying Molecular and Temporal Aspects of Malaria Parasite Invasion

(2016) Greta E. Weiss et al.   TRENDS IN PARASITOLOGY

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

(2016) Victoria Ryg-Cornejo et al.   Cell Reports

A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys

(2015) Alexander D. Douglas et al.   Cell Host & Microbe

Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria

(2015) Michelle J. Boyle et al.   IMMUNITY

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-StagePlasmodium falciparumInfection

(2015) Alexander T. Kennedy et al.   JOURNAL OF IMMUNOLOGY

Antibodies to thePlasmodium falciparumProteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria

(2015) Chris Y. H. Chiu et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparumProtein Microarray Antibody Profiles Correlate With Protection From Symptomatic Malaria in Kenya

(2015) Arlene E. Dent et al.   JOURNAL OF INFECTIOUS DISEASES

Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial forPlasmodium falciparumerythrocyte invasion

(2015) K. Sony Reddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large screen approaches to identify novel malaria vaccine candidates

(2015) D. Huw Davies et al.   VACCINE

Standardization of the antibody-dependent respiratory burst assay with human neutrophils and Plasmodium falciparum malaria

(2015) David Llewellyn et al.   Scientific Reports

Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

(2015) Nyamekye Obeng-Adjei et al.   Cell Reports

Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children

(2015) Regis W. Tiendrebeogo et al.   Open Forum Infectious Diseases

Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria

(2014) Faith HA Osier et al.   BMC Medicine

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes byPlasmodium falciparum

(2014) Clara S. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of Biological Activity of Human Anti-Apical Membrane Antigen-1 Antibodies Induced by Natural Infection and Vaccination

(2014) K. Miura et al.   JOURNAL OF IMMUNOLOGY

Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum

(2014) Stephanie Kapelski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies

(2014) Katherine E. Wright et al.   NATURE

Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection

(2014) D. K. Raj et al.   SCIENCE

New antigens for a multicomponent blood-stage malaria vaccine

(2014) F. H. Osier et al.   Science Translational Medicine

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

(2014) Lin Chen et al.   eLife

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

(2014) Chris Y. H. Chiu et al.   Frontiers in Microbiology

Malaria Parasites Co-opt Human Factor H to Prevent Complement-Mediated Lysis in the Mosquito Midgut

(2013) Nina Simon et al.   Cell Host & Microbe

Sequential Processing of Merozoite Surface Proteins during and after Erythrocyte Invasion by Plasmodium falciparum

(2013) Michelle J. Boyle et al.   INFECTION AND IMMUNITY

Identification and Prioritization of Merozoite Antigens as Targets of Protective Human Immunity to Plasmodium falciparum Malaria for Vaccine and Biomarker Development

(2013) J. S. Richards et al.   JOURNAL OF IMMUNOLOGY

Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria

(2013) Tuan M. Tran et al.   JOURNAL OF INFECTIOUS DISEASES

A Library of Functional Recombinant Cell-surface and SecretedP. falciparumMerozoite Proteins

(2013) Cécile Crosnier et al.   MOLECULAR & CELLULAR PROTEOMICS

Antibodies to Polymorphic Invasion-Inhibitory and Non-Inhibitory Epitopes of Plasmodium falciparum Apical Membrane Antigen 1 in Human Malaria

(2013) Cleopatra K. Mugyenyi et al.   PLoS One

Opsonising Antibodies to P. falciparum Merozoites Associated with Immunity to Clinical Malaria

(2013) Danika L. Hill et al.   PLoS One

Crystal and Solution Structures ofPlasmodium falciparumErythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion

(2012) Daniel H. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broadly reactive antibodies specific for Plasmodium falciparum MSP-119 are associated with the protection of naturally exposed children against infection

(2012) Arlene E Dent et al.   MALARIA JOURNAL

The Plasmodium falciparum Erythrocyte Invasion Ligand Pfrh4 as a Target of Functional and Protective Human Antibodies against Malaria

(2012) Linda Reiling et al.   PLoS One

Efficient Measurement of Opsonising Antibodies to Plasmodium falciparum Merozoites

(2012) Danika L. Hill et al.   PLoS One

Antibodies to Plasmodium falciparum Erythrocyte-binding Antigen-175 are Associated With Protection From Clinical Malaria

(2011) Matthew B. McCarra et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Quantifying the Importance of MSP1-19 as a Target of Growth-Inhibitory and Protective Antibodies against Plasmodium falciparum in Humans

(2011) Danny W. Wilson et al.   PLoS One

Binding ofPlasmodiummerozoite proteins RON2 and AMA1 triggers commitment to invasion

(2011) Prakash Srinivasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum

(2011) Wai-Hong Tham et al.   TRENDS IN PARASITOLOGY

An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum

(2011) Lin Chen et al.   PLoS Pathogens

Complement driven innate immune response to malaria: fuelling severe malarial diseases

(2010) Karlee L. Silver et al.   CELLULAR MICROBIOLOGY

Association between Naturally Acquired Antibodies to Erythrocyte‐Binding Antigens ofPlasmodium falciparumand Protection from Malaria and High‐Density Parasitemia

(2010) Jack S. Richards et al.   CLINICAL INFECTIOUS DISEASES

Evidence That the Erythrocyte Invasion Ligand PfRh2 is a Target of Protective Immunity against Plasmodium falciparum Malaria

(2010) L. Reiling et al.   JOURNAL OF IMMUNOLOGY

Erythrocyte Invasion and Merozoite Ligand Gene Expression in Severe and MildPlasmodium falciparumMalaria

(2010) Natalia Gomez‐Escobar et al.   JOURNAL OF INFECTIOUS DISEASES

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

(2010) Lars M Joergensen et al.   MALARIA JOURNAL

Clinical Protection from Falciparum Malaria Correlates with Neutrophil Respiratory Bursts Induced by Merozoites Opsonized with Human Serum Antibodies

(2010) Charlotte Joos et al.   PLoS One

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

(2010) P. D. Crompton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

(2010) Freya J. I. Fowkes et al.   PLOS MEDICINE

Long-Lived Antibody and B Cell Memory Responses to the Human Malaria Parasites, Plasmodium falciparum and Plasmodium vivax

(2010) Jiraprapa Wipasa et al.   PLoS Pathogens

The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections

(2010) Greta E. Weiss et al.   PLoS Pathogens

The wheat germ cell-free protein synthesis system: A key tool for novel malaria vaccine candidate discovery

(2009) Takafumi Tsuboi et al.   ACTA TROPICA

Strain-Specific Duffy Binding Protein Antibodies Correlate with Protection against Infection with Homologous Compared to Heterologous Plasmodium vivax Strains in Papua New Guinean Children

(2009) J. L. Cole-Tobian et al.   INFECTION AND IMMUNITY

In Vitro Growth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali

(2009) P. D. Crompton et al.   INFECTION AND IMMUNITY

Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness

(2009) D. I. Stanisic et al.   INFECTION AND IMMUNITY

Submicroscopic Infection inPlasmodium falciparum–Endemic Populations: A Systematic Review and Meta‐Analysis

(2009) Lucy C. Okell et al.   JOURNAL OF INFECTIOUS DISEASES

MSP-1p42-specific antibodies affect growth and development of intra-erythrocytic parasites of Plasmodium falciparum

(2009) Elke S Bergmann-Leitner et al.   MALARIA JOURNAL

Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya

(2009) Bernhards R. Ogutu et al.   PLoS One

Antigenic Variation in Plasmodium falciparum

(2008) Artur Scherf et al.   Annual Review of Microbiology

Reticulocyte-binding protein homologue 5 – An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

(2008) Jake Baum et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

MSP119miniproteins can serve as targets for invasion inhibitory antibodies in Plasmodium falciparum provided they contain the correct domains for cell surface trafficking

(2008) Paul R. Gilson et al.   MOLECULAR MICROBIOLOGY

Formation of the Food Vacuole in Plasmodium falciparum: A Potential Role for the 19 kDa Fragment of Merozoite Surface Protein 1 (MSP119)

(2008) Anton R. Dluzewski et al.   PLoS One

Antibody-Mediated Growth Inhibition of Plasmodium falciparum: Relationship to Age and Protection from Parasitemia in Kenyan Children and Adults

(2008) Arlene E. Dent et al.   PLoS One

Profiling humoral immune responses to P. falciparum infection with protein microarrays

(2008) Denise L. Doolan et al.   PROTEOMICS

Longitudinal analyses of immune responses to Plasmodium falciparum derived peptides corresponding to novel blood stage antigens in coastal Kenya

(2008) George W. Agak et al.   VACCINE