Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome

Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria

(2017) Sanduni U. Liyanage et al.   MITOCHONDRION

The mitochondrial genome. The nucleoid

(2016) A. A. Kolesnikov   BIOCHEMISTRY-MOSCOW

Delaunay algorithm and principal component analysis for 3D visualization of mitochondrial DNA nucleoids by Biplane FPALM/dSTORM

(2016) Lukáš Alán et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

p53 as guardian of the mitochondrial genome

(2016) Ji-Hoon Park et al.   FEBS LETTERS

Regulation of mitochondrial genome replication by hypoxia: The role of DNA oxidation in D-loop region

(2016) Viktor M. Pastukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA mitochondrial dysfunction and cardiac manifestations

(2016) Jin Han   Frontiers in Bioscience-Landmark

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease

(2016) Sentiljana Gumeni et al.   Oxidative Medicine and Cellular Longevity

Accurate concentration control of mitochondria and nucleoids

(2016) R. Jajoo et al.   SCIENCE

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress

(2016) Lukáš Alán et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function

(2016) Nicole Schwarz et al.   Cells

Structure and function of mitochondrial membrane protein complexes

(2015) Werner Kühlbrandt   BMC BIOLOGY

Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization

(2015) H Li et al.   CELL DEATH AND DIFFERENTIATION

Cardiovascular Disease, Mitochondria, and Traditional Chinese Medicine

(2015) Jie Wang et al.   Evidence-based Complementary and Alternative Medicine

Mitochondria–nucleus network for genome stability

(2015) Aneta Kaniak-Golik et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interaction of human mitochondrial transcription factor A in mitochondria: its involvement in the dynamics of mitochondrial DNA nucleoids

(2015) Katsumi Kasashima et al.   GENES TO CELLS

Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome

(2015) X.Z. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Distribution of mitochondrial DNA nucleoids inside the linear tubules vs. bulk parts of mitochondrial network as visualized by 4Pi microscopy

(2015) Andrea Dlasková et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Coupled aggregation of mitochondrial single-strand DNA-binding protein tagged with Eos fluorescent protein visualizes synchronized activity of mitochondrial nucleoids

(2015) TOMÁŠ OLEJÁR et al.   Molecular Medicine Reports

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes

(2015) Fernanda Marques da Cunha et al.   Oxidative Medicine and Cellular Longevity

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

(2015) Christian Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protecting the mitochondrial powerhouse

(2015) Morten Scheibye-Knudsen et al.   TRENDS IN CELL BIOLOGY

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

(2015) Joachim M. Gerhold et al.   Scientific Reports

Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies

(2015) Kirsten Kehrein et al.   Cell Reports

Whole Cell Formaldehyde Cross-Linking Simplifies Purification of Mitochondrial Nucleoids and Associated Proteins Involved in Mitochondrial Gene Expression

(2015) Nina Rajala et al.   PLoS One

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

(2014) P. A. Gammage et al.   EMBO Molecular Medicine

Mitochondrial Disease

(2014) Ben Thornton et al.   JOURNAL OF CHILD NEUROLOGY

Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation

(2014) Huu B. Ngo et al.   Nature Communications

In Vitro-Reconstituted Nucleoids Can Block Mitochondrial DNA Replication and Transcription

(2014) Géraldine Farge et al.   Cell Reports

Nucleoid localization of Hsp40 Mdj1 is important for its function in maintenance of mitochondrial DNA

(2013) Grzegorz L. Ciesielski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

To be or not to be a nucleoid protein: A comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins

(2013) Fenna Hensen et al.   BIOCHIMIE

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

(2013) D. Milenkovic et al.   HUMAN MOLECULAR GENETICS

From Structure to Function: Mitochondrial Morphology, Motion and Shaping in Vascular Smooth Muscle

(2013) John G. McCarron et al.   JOURNAL OF VASCULAR RESEARCH

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c

(2013) R. Ban-Ishihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mtDNA makes a U-turn for the mitochondrial nucleoid

(2013) Christian Kukat et al.   TRENDS IN CELL BIOLOGY

The Mitochondrial Nucleoid: Integrating Mitochondrial DNA into Cellular Homeostasis

(2013) R. Gilkerson et al.   Cold Spring Harbor Perspectives in Biology

Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging

(2013) Jenny K. Ngo et al.   Redox Biology

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX

(2012) Katsumi Kasashima et al.   EXPERIMENTAL CELL RESEARCH

Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells

(2012) Jan Tauber et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression

(2012) Shuijie Li et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The influence of ATP-dependent proteases on a variety of nucleoid-associated processes

(2012) L’uboš Ambro et al.   JOURNAL OF STRUCTURAL BIOLOGY

Phosphorylation of Human TFAM in Mitochondria Impairs DNA Binding and Promotes Degradation by the AAA+ Lon Protease

(2012) Bin Lu et al.   MOLECULAR CELL

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

(2012) J. He et al.   NUCLEIC ACIDS RESEARCH

How Cells Know the Size of Their Organelles

(2012) Y.-H. M. Chan et al.   SCIENCE

Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A

(2012) Géraldine Farge et al.   Nature Communications

Matrix proteases in mitochondrial DNA function

(2011) Yuichi Matsushima et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mitochondrial DNA nucleoid structure

(2011) Daniel F. Bogenhagen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The mitochondrial contact site complex, a determinant of mitochondrial architecture

(2011) Max Harner et al.   EMBO JOURNAL

LRP130 Protein Remodels Mitochondria and Stimulates Fatty Acid Oxidation

(2011) Lijun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial DNA transcription regulation and nucleoid organization

(2011) Adriana P. Rebelo et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics

(2011) David M Krzywanski et al.   LABORATORY INVESTIGATION

Mitochondrial shape changes: orchestrating cell pathophysiology

(2010) Silvia Campello et al.   EMBO REPORTS

OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution

(2010) G. Elachouri et al.   GENOME RESEARCH

Topological analysis of ATAD3A insertion in purified human mitochondria

(2010) Arnaud Hubstenberger et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

ERMES-mediated ER-mitochondria contacts: molecular hubs for the regulation of mitochondrial biology

(2010) B. Kornmann et al.   JOURNAL OF CELL SCIENCE

OPA1 (dys)functions

(2010) Thomas Landes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Functional complementation of mitochondrial DNAs: Mobilizing mitochondrial genetics against dysfunction

(2009) Eric A. Schon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Does mtDNA nucleoid organization impact aging?

(2009) Daniel F. Bogenhagen   EXPERIMENTAL GERONTOLOGY

Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia

(2009) Petr Ježek et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial DNA nucleoids determine mitochondrial genetics and dysfunction

(2009) Robert W. Gilkerson   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Functional organization of mammalian mitochondrial DNA in nucleoids: History, recent developments, and future challenges

(2009) Johannes N. Spelbrink   IUBMB LIFE

Association of a Novel Mitochondrial Protein M19 with Mitochondrial Nucleoids

(2009) Megumi Sumitani et al.   JOURNAL OF BIOCHEMISTRY

The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells

(2009) M. Di Re et al.   NUCLEIC ACIDS RESEARCH

Structural implications of mitochondrial dynamics

(2008) Jürgen Bereiter-Hahn et al.   Biotechnology Journal

The Mitochondrial Proteome: From Inventory to Function

(2008) Chris Meisinger et al.   CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Human prohibitin 1 maintains the organization and stability of the mitochondrial nucleoids

(2008) Katsumi Kasashima et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

(2008) Robert W. Gilkerson et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial nucleoids undergo remodeling in response to metabolic cues

(2008) M. Kucej et al.   JOURNAL OF CELL SCIENCE

Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p

(2007) Malgorzata Macierzanka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH