The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

(2014) A. M. Cook et al.   BLOOD

Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability

(2014) Marta M. Fay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface

(2014) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing

(2013) Jihyun Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score

(2013) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

(2013) Xiangxiang Bao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27Kip1

(2013) Courtney Nicholas et al.   PLoS One

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

(2012) Zhongping Gu et al.   BIOCHEMICAL JOURNAL

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia

(2012) W. Blum et al.   BLOOD

Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia

(2012) A Mims et al.   LEUKEMIA

HOXA9 Methylation by PRMT5 Is Essential for Endothelial Cell Expression of Leukocyte Adhesion Molecules

(2012) S. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1

(2011) Yi-Kun Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene mutation and AML pathogenesis

(2011) H. Dombret   BLOOD

JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation

(2011) Fan Liu et al.   CANCER CELL

Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications

(2011) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Fragment-Based Drug Design and Drug Repositioning Using Multiple Ligand Simultaneous Docking (MLSD): Identifying Celecoxib and Template Compounds as Novel Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3)

(2011) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

(2010) G. Rank et al.   BLOOD

Sp1/NFκB/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia

(2010) Shujun Liu et al.   CANCER CELL

Evaluation of the performance of four molecular docking programs on a diverse set of protein-ligand complexes

(2010) Xun Li et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine

(2010) W. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

MicroRNA 29b functions in acute myeloid leukemia

(2009) R. Garzon et al.   BLOOD

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML

(2009) Ellen Weisberg et al.   DRUG RESISTANCE UPDATES

Epigenetics in cancer: Targeting chromatin modifications

(2009) L. Ellis et al.   MOLECULAR CANCER THERAPEUTICS

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

(2009) A. Scoumanne et al.   NUCLEIC ACIDS RESEARCH

Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors

(2008) Dawid Eckert et al.   BMC DEVELOPMENTAL BIOLOGY

Protein Arginine Methyltransferase 5 Suppresses the Transcription of the RB Family of Tumor Suppressors in Leukemia and Lymphoma Cells

(2008) L. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY