JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21

Targeting CDK4/6 in patients with cancer

(2016) Erika Hamilton et al.   CANCER TREATMENT REVIEWS

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

(2015) M. Fallahi-Sichani et al.   Molecular Systems Biology

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer

(2015) Nicholas C. Turner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting CDK4 and CDK6: From Discovery to Therapy

(2015) C. J. Sherr et al.   Cancer Discovery

The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes

(2014) Sabine Paternot et al.   CELL CYCLE

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

(2013) Miriam Merzel Schachter et al.   MOLECULAR CELL

CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point

(2013) Xavier Bisteau et al.   PLoS Genetics

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Regulation of p27Kip1by mitogen-induced tyrosine phosphorylation

(2012) Heidelinde Jäkel et al.   CELL CYCLE

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

(2012) Miguel Ganuza et al.   EMBO JOURNAL

Rb inactivation in cell cycle and cancer: The puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase

(2011) Sabine Paternot et al.   CELL CYCLE

The role of JNK in the development of hepatocellular carcinoma

(2011) Madhumita Das et al.   GENES & DEVELOPMENT

Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation

(2011) C. Cellurale et al.   MOLECULAR AND CELLULAR BIOLOGY

Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation

(2011) Katia Coulonval et al.   MOLECULAR BIOLOGY OF THE CELL

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

The Mitogen-Activated Protein Kinase Kinase 4 Has a Pro-Oncogenic Role in Skin Cancer

(2010) K. G. Finegan et al.   CANCER RESEARCH

cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4

(2010) Sara Blancquaert et al.   MOLECULAR ENDOCRINOLOGY

The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis

(2010) R T Nitta et al.   ONCOGENE

Knockdown of the c-Jun-N-terminal kinase expression by siRNA inhibits MCF-7 breast carcinoma cell line growth

(2010) Parra   ONCOLOGY REPORTS

Combined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation

(2009) S. Paternot et al.   CANCER RESEARCH

Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation

(2009) L. Bockstaele et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular Signal-Regulated Kinase 2-Dependent Phosphorylation Induces Cytoplasmic Localization and Degradation of p21Cip1

(2009) C. Y. Hwang et al.   MOLECULAR AND CELLULAR BIOLOGY

Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells

(2009) J. Cui et al.   MOLECULAR CANCER THERAPEUTICS

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms

(2009) A Satyanarayana et al.   ONCOGENE

Constitutive Activity of JNK2α2 Is Dependent on a Unique Mechanism of MAPK Activation

(2008) Ryan T. Nitta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

(2008) Lijian Hui et al.   JOURNAL OF CLINICAL INVESTIGATION

p27Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes

(2008) A. Ray et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclic AMP Inhibits the Proliferation of Thyroid Carcinoma Cell Lines through Regulation of CDK4 Phosphorylation

(2008) Ana Sofia Rocha et al.   MOLECULAR BIOLOGY OF THE CELL

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY