CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point

A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression

(2013) Miriam Merzel Schachter et al.   MOLECULAR CELL

Mechanism of Cell Cycle Entry Mediated by the Intrinsically Disordered Protein p27Kip1

(2012) Li Ou et al.   ACS Chemical Biology

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Why minimal is not optimal: Driving the mammalian cell cycle—and drug discovery—with a physiologic CDK control network

(2012) Karl A. Merrick et al.   CELL CYCLE

Regulation of p27Kip1by mitogen-induced tyrosine phosphorylation

(2012) Heidelinde Jäkel et al.   CELL CYCLE

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion

(2012) Miguel Ganuza et al.   EMBO JOURNAL

Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

(2012) Patrick J. Roberts et al.   JNCI-Journal of the National Cancer Institute

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

(2012) Lawrence N Kwong et al.   NATURE MEDICINE

Rb inactivation in cell cycle and cancer: The puzzle of highly regulated activating phosphorylation of CDK4 versus constitutively active CDK-activating kinase

(2011) Sabine Paternot et al.   CELL CYCLE

Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation

(2011) Katia Coulonval et al.   MOLECULAR BIOLOGY OF THE CELL

Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

(2011) Yuefeng Wang et al.   Nature Chemical Biology

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

(2010) Marta Puyol et al.   CANCER CELL

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

Targeting the RB-pathway in Cancer Therapy

(2010) E. S. Knudsen et al.   CLINICAL CANCER RESEARCH

cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4

(2010) Sara Blancquaert et al.   MOLECULAR ENDOCRINOLOGY

Combined Inhibition of MEK and Mammalian Target of Rapamycin Abolishes Phosphorylation of Cyclin-Dependent Kinase 4 in Glioblastoma Cell Lines and Prevents Their Proliferation

(2009) S. Paternot et al.   CANCER RESEARCH

Differential Regulation of Cyclin-Dependent Kinase 4 (CDK4) and CDK6, Evidence that CDK4 Might Not Be Activated by CDK7, and Design of a CDK6 Activating Mutation

(2009) L. Bockstaele et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular Signal-Regulated Kinase 2-Dependent Phosphorylation Induces Cytoplasmic Localization and Degradation of p21Cip1

(2009) C. Y. Hwang et al.   MOLECULAR AND CELLULAR BIOLOGY

TFIIH-Associated Cdk7 Kinase Functions in Phosphorylation of C-Terminal Domain Ser7 Residues, Promoter-Proximal Pausing, and Termination by RNA Polymerase II

(2009) K. Glover-Cutter et al.   MOLECULAR AND CELLULAR BIOLOGY

The structure of CDK4/cyclin D3 has implications for models of CDK activation

(2009) T. Takaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p27Kip1 Inhibits Cyclin D-Cyclin-Dependent Kinase 4 by Two Independent Modes

(2008) A. Ray et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclic AMP Inhibits the Proliferation of Thyroid Carcinoma Cell Lines through Regulation of CDK4 Phosphorylation

(2008) Ana Sofia Rocha et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct Activation Pathways Confer Cyclin-Binding Specificity on Cdk1 and Cdk2 in Human Cells

(2008) Karl A. Merrick et al.   MOLECULAR CELL

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

(2008) K Bettayeb et al.   ONCOGENE