Novel C-C chemokine receptor 2 antagonists in metabolic disease: a review of recent developments

C-C Chemokine Receptor 2 Inhibitor Improves Diet-Induced Development of Insulin Resistance and Hepatic Steatosis in Mice

(2011) Yukinori Tamura et al.   Journal of Atherosclerosis and Thrombosis

Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2

(2010) Chu-Biao Xue et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

C-C Chemokine Receptor 2 (CCR2) Regulates the Hepatic Recruitment of Myeloid Cells That Promote Obesity-Induced Hepatic Steatosis

(2010) A. E. Obstfeld et al.   DIABETES

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

An Increase in the Circulating Concentration of Monocyte Chemoattractant Protein-1 Elicits Systemic Insulin Resistance Irrespective of Adipose Tissue Inflammation in Mice

(2010) Sanshiro Tateya et al.   ENDOCRINOLOGY

Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression

(2010) M Zeyda et al.   INTERNATIONAL JOURNAL OF OBESITY

CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

(2010) Amin Majdalawieh et al.   MEDIATORS OF INFLAMMATION

Innate immunity and adipose tissue biology

(2010) Andreas Schäffler et al.   TRENDS IN IMMUNOLOGY

CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE−/− mice

(2009) Robert J. Aiello et al.   ATHEROSCLEROSIS

Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2

(2009) Niu Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications

(2009) Jianli Niu et al.   CLINICAL SCIENCE

Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes

(2009) E. Tarabra et al.   DIABETES

Inhibition of the chemokine (C–C motif) ligand 2/chemokine (C–C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

(2009) S. J. Yang et al.   DIABETOLOGIA

Recent developments in CCR2 antagonists

(2009) Mingde Xia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chemokine receptor antagonists: Part 1

(2009) James E Pease et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

The role of GM-CSF in adipose tissue inflammation

(2008) Dong-Hoon Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice

(2008) Yukinori Tamura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series

(2008) Wilna J. Moree et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue

(2008) E. A. Kirk et al.   DIABETES

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue

(2008) Ayaka Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

(2008) Robert J. Cherney et al.   JOURNAL OF MEDICINAL CHEMISTRY