Article
Food Science & Technology
Poliana Guiomar de Almeida Brasiel, Sheila Cristina Potente Dutra Luquetti, Julliane Dutra Medeiros, Jose Otavio do Amaral Correa, Alessandra Barbosa Ferreira Machado, Ana Paula Boroni Moreira, Vincius Novaes Rocha, Claudio Teodoro de Souza, Maria Do Carmo Goveia Peluzio
Summary: Obesity is linked to chronic inflammation, intestinal dysbiosis, and colorectal cancer risk. Early life nutrition based on kefir can reverse these changes.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Medicine, Research & Experimental
Yan Wang, Hui Li
Summary: The gut microbiota plays a crucial role in the development of colorectal cancer, and various strategies have been developed to modify the microbiota. However, the potential implications and long-term effects of these strategies in clinical settings need to be evaluated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Michael W. Dougherty, Christian Jobin
Summary: The development of colorectal cancer is influenced by the presence of bacterial communities in the gastrointestinal tract. These microorganisms obtain essential nutrients from indigestible compounds and play a role in molecular signaling pathways that are necessary for normal tissue and immune function. Several bacterial species, such as Fusobacterium nucleatum, Enterotoxigenic Bacteroides fragilis, and pks(+) E. coli, have been identified to potentially increase the risk of colorectal cancer. Recent research has expanded on this topic to include host mutational status, microbial heterogeneity within tumors, transient infections, and the cumulative effects of multiple carcinogenic bacteria. This review provides an updated overview of how host-bacteria interactions influence colorectal cancer development, potential applications in diagnosis or prevention, and the impact of the gut microbiome on colorectal cancer treatment efficacy.
Review
Immunology
Hanghang Yuan, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao
Summary: Colorectal cancer (CRC) is a common and deadly cancer that poses a major burden on human health. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, but the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. This review discusses recent advances and the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC, providing references and fresh ideas for the clinical application of this novel strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ramesh Pothuraju, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur, Hemant K. Roy, Michael Bouvet, Surinder K. Batra
Summary: An imbalance in the crosstalk between host and gut microbiota can lead to inflammatory diseases and colorectal cancer, with dietary patterns playing a crucial role in regulating gut microbiota composition and maintaining mucin expression. Proper communication between host and gut microbiota through different dietary patterns is essential for maintaining mucus composition and regulation in health and disease.
Article
Biochemistry & Molecular Biology
Ifeoma Julieth Dikeocha, Abdelkodose Mohammed Al-Kabsi, Hsien-Tai Chiu, Mohammed Abdullah Alshawsh
Summary: This study demonstrated the potential role of F. prausnitzii in the prevention and management of colorectal cancer, showing its anti-tumorigenic and antiproliferative effects, as well as its modulation of gut microbiota diversity in rats.
Review
Nutrition & Dietetics
Maria do Carmo Gouveia Peluzio, Mariana de Moura e Dias, J. Alfredo Martinez, Fermin I. Milagro
Summary: Kefir, a fermented food with probiotic properties, can modulate gut microbiota composition and has preventive and management effects on diseases such as obesity, diabetes mellitus, liver disease, cardiovascular disorders, immunity, and neurological disorders. Due to its reported benefits, low cost, and ease of preparation, kefir seems to be a promising approach for preventing and managing microbiota-related diseases in Latin America and globally. Further research is needed to standardize bioactive compounds in kefir and better understand the mechanisms linking kefir and intestinal microbiota modulation.
FRONTIERS IN NUTRITION
(2021)
Review
Microbiology
Christina Thoda, Maria Touraki
Summary: Colorectal cancer (CRC) is a global disease with high morbidity and mortality rates. Drug resistance and side effects of chemotherapy have led to the need for alternative anticancer agents, such as probiotic-derived bioactive compounds. These compounds, including bacteriocins, short-chain fatty acids, and bacterial peptides, exhibit anti-inflammatory and antiproliferative properties. This review summarizes the classification and biological role of postbiotics, as well as their interaction with the gut microbiota and their potential for CRC prevention and treatment.
Review
Oncology
Himani Pandey, Daryl W. T. Tang, Sunny H. H. Wong, Devi Lal
Summary: Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. Gut microbiota play a significant role in promoting inflammation and tumor progression in CRC. Advances in next-generation sequencing technologies and metagenomics have provided new insights into the role of gut microbiota in CRC development and its potential applications in diagnosis, prevention, and treatment.
Review
Gastroenterology & Hepatology
Monika Kvakova, Anna Kamlarova, Jana Stofilova, Veronika Benetinova, Izabela Bertkova
Summary: Colorectal cancer is a major cause of death worldwide. Conventional anticancer therapy is not always effective, leading to growing interest in drug-free cancer treatments or interventions that improve the efficacy of established therapy. Supplementing patient treatment with probiotics, next-generation probiotics, or postbiotics can restore gut microbiota composition and/or signaling to the host, providing an effective and accessible complementary anticancer strategy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Food Science & Technology
Hadi Feizi, Andrey Plotnikov, Mohammad Ahangarzadeh Rezaee, Khudaverdi Ganbarov, Fadhil S. Kamounah, Sergei Nikitin, Hiva Kadkhoda, Pourya Gholizadeh, Pasquale Pagliano, Hossein Samadi Kafil
Summary: The mechanisms and applications of probiotics and postbiotics in preventing and treating early-onset colorectal cancer are of significant importance but are still subject to debate. Probiotics exert anticancer features through immune system regulation, inhibition of cancer cell propagation, and other mechanisms, while postbiotics restore eubiosis against EOCRC through modulation of gut microbiota composition, regulation of microbial metabolites, and improvement of intestinal barrier function.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Bin Wang, Xuheng Chen, Zhiyuan Chen, Huiwen Xiao, Jiali Dong, Yuan Li, Xiaozhou Zeng, Jinjian Liu, Guoyun Wan, Saijun Fan, Ming Cui
Summary: In this study, the researchers found that stable colonization of live A. muciniphila at lesion sites is essential for its anti-inflammatory function. They also developed a modified A. muciniphila that had enhanced inflammation targeting and intestinal colonization under an external magnetic field, leading to improved therapeutic efficacy against intestinal diseases. The findings further revealed that this modified A. muciniphila could drive M2 macrophage polarization by upregulating the protein level of IL-4 at inflammatory loci. These results demonstrate the importance of A. muciniphila in treating intestinal diseases.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Alice Bertocchi, Sara Carloni, Paola Simona Ravenda, Giovanni Bertalot, Ilaria Spadoni, Antonino Lo Cascio, Sara Gandini, Michela Lizier, Daniele Braga, Francesco Asnicar, Nicola Segata, Chris Klaver, Paola Brescia, Elio Rossi, Achille Anselmo, Silvia Guglietta, Annalisa Maroli, Paola Spaggiari, Noelia Tarazona, Andres Cervantes, Silvia Marsoni, Luca Lazzari, Maria Giovanna Jodice, Chiara Luise, Marco Erreni, Salvatore Pece, Pier Paolo Di Fiore, Giuseppe Viale, Antonino Spinelli, Chiara Pozzi, Giuseppe Penna, Maria Rescigno
Summary: Bacteria from primary tumors can lead to bacterial dissemination from the intestine to the liver, disrupting the gut vascular barrier, boosting the formation of a premetastatic niche, and enhancing the recruitment of metastatic cells. High levels of PV-1, a marker of impaired gut vascular barrier, are associated with liver bacteria dissemination and metachronous distant metastases in colorectal cancer patients, making it a prognostic marker for distant recurrence and vascular impairment.
Article
Pharmacology & Pharmacy
Lijuan Wei, Liwei Duan, Hongyu Zhao, Jinghua Tai
Summary: This review discusses the positive effects and mechanisms of action of mixed probiotics, specifically VSL#3, on colorectal cancer, providing new ideas for its treatment. The need to explore more therapeutic possibilities, especially through the research and application of synbiotics and postbiotics, is also emphasized.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Food Science & Technology
Seung Yun Lee, Da Young Lee, Ji Hyeop Kang, Jae Hyeon Kim, Jae Won Jeong, Hyun Woo Kim, Dong Hoon Oh, Seung Hyeon Yoon, Sun Jin Hur
Summary: This article highlights the effects of meat intake and fermented foods on gut microbiota and their role in the development of colorectal cancer (CRC). The gut microbiota can influence CRC through various mechanisms, including toxin secretion, activation of carcinogenic enzymes, inflammation, and oxidative stress. Additionally, the composition of gut microbiota plays a role in antioxidant activities, antimicrobial effects, and inhibition of pathogen colonization.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Nutrition & Dietetics
Monise Viana Abranches, Fernanda Cristina Esteves de Oliveira, Lisiane Lopes da Conceicao, Maria do Carmo Gouveia Peluzio
NUTRITION RESEARCH REVIEWS
(2015)
Article
Nutrition & Dietetics
Lisiane Lopes da Conceicao, Mariana de Moura e Dias, Milene Cristine Pessoa, Georgia das Gracas Pena, Maria Carolina Santos Mendes, Cristiane Vilas Boas Neves, Helen Hermana Miranda Hermsdorff, Renata Nascimento de Freitas, Maria do Carmo Gouveia Peluzio
NUTRICION HOSPITALARIA
(2016)
Review
Nutrition & Dietetics
S. A. Reis, L. L. Conceicao, D. D. Rosa, N. P. Siqueira, M. C. G. Peluzio
NUTRITION RESEARCH REVIEWS
(2017)
Review
Nutrition & Dietetics
Damiana D. Rosa, Manoela M. S. Dias, Lukasz M. Grzes'kowiak, Sandra A. Reis, Lisiane L. Conceicao, Maria do Carmo G. Peluzio
NUTRITION RESEARCH REVIEWS
(2017)
Article
Food Science & Technology
Eliana dos Santos Leandro, Emiliane Andrade de Araujo, Lisiane Lopes da Conceicao, Celia Alencar de Moraes, Antonio Fernandes de Carvalho
JOURNAL OF FUNCTIONAL FOODS
(2013)
Article
Food Science & Technology
Mariana de Moura e Dias, Nathane Pais Siqueira, Lisiane Lopes da Conceicao, Sandra Aparecida dos Reis, Flavia Xavier Valente, Manoela Maciel dos Santos Dias, Carla de Oliveira Barbosa Rosa, Sergio Oliveira de Paula, Sergio Luis Pinto da Matta, Leandro Licursi de Oliveira, Josefina Bressan, Maria do Carmo Gouveia Peluzio
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Microbiology
L. L. da Conceicao, E. S. Leandro, F. S. Freitas, M. N. V. de Oliveira, A. B. Ferreira-Machado, A. C. Borges, C. A. de Moraes
BENEFICIAL MICROBES
(2013)
Article
Food Science & Technology
Sandra Aparecida dos Reis, Lisiane Lopes da Conceicao, Mariana Moura e Dias, Nathane Paes Siqueira, Damiana Diniz Rosa, Leandro Licursi de Oliveira, Sergio Luis Pinto da Matta, Maria do Carmo Gouveia Peluzio
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Food Science & Technology
Alexandre Azevedo Novello, Lisiane Lopes Da Conceicao, Manoela Maciel Dos Santos Dias, Luciana Marques Cardoso, Cynthia Aparecida De Castro, Maria Esther Ricci-Silva, Joao Paulo Viana Leite, Maria Do Carmo Gouveia Peluzio
JOURNAL OF FOOD AND NUTRITION RESEARCH
(2015)
Review
Nutrition & Dietetics
Sandra Aparecida dos Reis, Lisiane Lopes da Conceicao, Damiana Diniz Rosa, Manoela Maciel dos Santos Dias, Maria do Carmo Gouveia Peluzio
NUTRICION HOSPITALARIA
(2015)