Acquired Amino Acid Deficiencies: A Focus on Arginine and Glutamine

Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice

(2016) Jochen Steppan et al.   ANESTHESIA AND ANALGESIA

Human Protein and Amino Acid Requirements

(2016) L. John Hoffer   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient

(2016) Stephen A. McClave et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Asymmetric Dimethylarginine in Adult Falciparum Malaria: Relationships With Disease Severity, Antimalarial Treatment, Hemolysis, and Inflammation

(2016) Bridget E. Barber et al.   Open Forum Infectious Diseases

Should perioperative immunonutrition for elective surgery be the current standard of care?: Table 1.

(2016) Shishira Bharadwaj et al.   Gastroenterology Report

Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice

(2015) Matthew L. Johnson et al.   AGING CELL

Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: a multicenter, prospective, cohort study1

(2015) Nilesh M Mehta et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vasculopathy and pulmonary hypertension in sickle cell disease

(2015) Karin P. Potoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function

(2015) Michael G. Risbano et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Maternal l-glutamine supplementation prevents prenatal alcohol exposure-induced fetal growth restriction in an ovine model

(2015) Onkar B. Sawant et al.   AMINO ACIDS

Revisiting the hyperhemolysis paradigm

(2015) M. T. Gladwin   BLOOD

Dysregulated arginine metabolism and cardiopulmonary dysfunction in patients with thalassaemia

(2015) Claudia R. Morris et al.   BRITISH JOURNAL OF HAEMATOLOGY

Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability

(2015) Yvette C. Luiking et al.   CLINICAL SCIENCE

Consequences of the REDOXS and METAPLUS Trials

(2015) Arthur R. H. van Zanten et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Immune enhancing nutrition in traumatic brain injury – A preliminary study

(2015) Thomas J. Painter et al.   International Journal of Surgery

Citrulline Supplementation Improves Organ Perfusion and Arginine Availability under Conditions with Enhanced Arginase Activity

(2015) Karolina Wijnands et al.   Nutrients

Oral supplementation with a combination of l-citrulline and l-arginine rapidly increases plasma l-arginine concentration and enhances NO bioavailability

(2014) Masahiko Morita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Erythroid DAMPs drive inflammation in SCD

(2014) M. T. Gladwin et al.   BLOOD

High protein diet attenuates histopathologic organ damage and vascular leakage in transgenic murine model of sickle cell anemia

(2014) Elizabeth Ann Manci et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Alterations of the Arginine Metabolome in Sickle Cell Disease

(2014) Claudia R. Morris   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Major surgical trauma differentially affects T-cells and APC

(2014) Markus Albertsmeier et al.   Innate Immunity

Metabolic Mysteries of the Inflammatory Response: T Cell Polarization and Plasticity

(2014) Kelley M. Fracchia et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU

(2014) Arthur R. H. van Zanten et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Omega-3 supplementation alters mitochondrial membrane composition and respiration kinetics in human skeletal muscle

(2014) E. A. F. Herbst et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Asymmetric dimethylarginine levels in children with β-thalassemia and their correlations to tricuspid regurgitant jet velocity

(2014) El-Shanshory Mohamed et al.   PEDIATRIC BLOOD & CANCER

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Cellular, Pharmacological, and Biophysical Evaluation of Explanted Lungs from a Patient with Sickle Cell Disease and Severe Pulmonary Arterial Hypertension

(2014) Natasha M. Rogers et al.   Pulmonary Circulation

The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury

(2013) Xinmei Zhu et al.   ANNALS OF SURGERY

Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils

(2013) Christabelle J. Darcy et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Asymmetric dimethylarginine levels in children with sickle cell disease and its correlation to tricuspid regurgitant jet velocity

(2013) Mohamed El-Shanshory et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension

(2013) C. R. Morris et al.   HAEMATOLOGICA

A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes

(2013) C. R. Morris et al.   HAEMATOLOGICA

Arginine administration to critically ill patients with a low nitric oxide fraction in the airways: a pilot study

(2013) Jean-Marc Tadié et al.   INTENSIVE CARE MEDICINE

Diminished Global Arginine Bioavailability as a Metabolic Defect in Chronic Systolic Heart Failure

(2013) W. H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

Role of Glutamine Supplementation in Critical Illness Given the Results of the REDOXS Study

(2013) Daren K. Heyland et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma

(2013) Erin L. Vanzant et al.   Journal of Trauma and Acute Care Surgery

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

(2013) Daren Heyland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nutritional Support for Patients Sustaining Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Prospective Studies

(2013) Xiang Wang et al.   PLoS One

A Randomized Pilot Study of L-Arginine Infusion in Severe Falciparum Malaria: Preliminary Safety, Efficacy and Pharmacokinetics

(2013) Tsin W. Yeo et al.   PLoS One

Multifactorial risk factor intervention in patients with Type 2 diabetes improves arginine bioavailability ratios

(2012) N. J. Tripolt et al.   DIABETIC MEDICINE

The immune response to surgery and trauma

(2012) Paul E. Marik et al.   Journal of Trauma and Acute Care Surgery

Increased protein-energy intake promotes anabolism in critically ill infants with viral bronchiolitis: a double-blind randomised controlled trial

(2011) C. T. de Betue et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Global arginine bioavailability in Tanzanian sickle cell anaemia patients at steady-state: a nested case control study of deaths versus survivors

(2011) Sharon E. Cox et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Arginases and arginine deficiency syndromes

(2011) Sidney M. Morris   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Endotoxemia affects citrulline, arginine and glutamine bioavailability

(2011) Fatimazahra Elwafi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Systemic Arginine Depletion After a Murine Model of Surgery or Trauma

(2011) John P. Pribis et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Perioperative Use of Arginine-supplemented Diets: A Systematic Review of the Evidence

(2011) John W. Drover et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Storage lesion: role of red blood cell breakdown

(2011) Daniel B. Kim-Shapiro et al.   TRANSFUSION

Immunonutrition nach Trauma

(2011) T.W. Felbinger et al.   UNFALLCHIRURG

Dysregulation of l-arginine metabolism and bioavailability associated to free plasma heme

(2010) F. Omodeo-Salè et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pulmonary hypertension in thalassemia

(2010) Claudia R. Morris et al.   Annals of the New York Academy of Sciences

A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers

(2010) Lillian McMahon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Docosahexaenoic Acid Reduces Traumatic Axonal Injury in a Rodent Head Injury Model

(2010) Julian E. Bailes et al.   JOURNAL OF NEUROTRAUMA

Bad Blood: The risks of red cell storage

(2010) Janet S Lee et al.   NATURE MEDICINE

Packed Red Blood Cells Suppress T-Cell Proliferation Through a Process Involving Cell–Cell Contact

(2010) Andrew Bernard et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Asthma management: Reinventing the wheel in sickle cell disease

(2009) Claudia R. Morris   AMERICAN JOURNAL OF HEMATOLOGY

l-Glutamine or l-alanyl-l-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes

(2009) Tony E. Haynes et al.   AMINO ACIDS

Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death

(2009) Gregory J. Kato et al.   BRITISH JOURNAL OF HAEMATOLOGY

Role of glutamine supplementation in critically ill patients

(2009) Jan Wernerman   Current Opinion in Anesthesiology

Hematologic, biochemical, and cardiopulmonary effects of l-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy

(2009) Jane A. Little et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Arginine is Essential in Reversing Prostaglandin E2 T-Cell Suppression by Hypertonic Saline

(2009) Sung Hyuk Choi et al.   JOURNAL OF SURGICAL RESEARCH

Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk

(2009) W.H. Wilson Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of arginine in superficial wound healing in man

(2009) I.B.J.G. Debats et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

(2008) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arginine metabolism and nutrition in growth, health and disease

(2008) Guoyao Wu et al.   AMINO ACIDS

Pharmacokinetics of L-Arginine in Adults with Moderately Severe Malaria

(2008) T. W. Yeo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nitric Oxide and Arginine Dysregulation: A Novel Pathway to Pulmonary Hypertension in Hemolytic Disorders

(2008) Claudia Morris et al.   CURRENT MOLECULAR MEDICINE

Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids

(2008) Paul R.S. Baker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pulmonary Hypertension

(2008) Christopher F. Barnett et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nitro-fatty Acid Formation and Signaling

(2008) Bruce A. Freeman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasmal‐Arginine and Blood Lactate Concentrations

(2008) Tsin W. Yeo et al.   JOURNAL OF INFECTIOUS DISEASES

Arginase and pulmonary diseases

(2008) Harm Maarsingh et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Neurological Benefits of Omega-3 Fatty Acids

(2008) S. C. Dyall et al.   NEUROMOLECULAR MEDICINE

Safety Profile of L-Arginine Infusion in Moderately Severe Falciparum Malaria

(2008) Tsin W. Yeo et al.   PLoS One

Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism

(2007) Edzard Schwedhelm et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Red blood cell arginase suppresses Jurkat (T cell) proliferation by depleting arginine

(2007) Andrew Bernard et al.   SURGERY