Cellular, Pharmacological, and Biophysical Evaluation of Explanted Lungs from a Patient with Sickle Cell Disease and Severe Pulmonary Arterial Hypertension

First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno-Occlusive Disease

(2014) M. Patricia George et al.   Pulmonary Circulation

Hemodynamic Predictors of Mortality in Adults with Sickle Cell Disease

(2013) Alem Mehari et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Thrombospondin-1 Regulates Blood Flow via CD47 Receptor–Mediated Activation of NADPH Oxidase 1

(2012) Gábor Csányi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1

(2012) Philip M. Bauer et al.   CARDIOVASCULAR RESEARCH

Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47

(2012) David R Soto-Pantoja et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe

(2012) M. Nouraie et al.   HAEMATOLOGICA

Mortality in Adults With Sickle Cell Disease and Pulmonary Hypertension

(2012) Alem Mehari et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension

(2012) Jun Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Altered Patterns of Endothelial Progenitor Cells in Sickle Cell Disease Related Pulmonary Arterial Hypertension

(2012) Fatima Anjum et al.   Pulmonary Circulation

Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates

(2011) Enrico M Novelli et al.   AMERICAN JOURNAL OF HEMATOLOGY

Pulmonary Arterial Hypertension

(2011) Eric S. Papierniak et al.   AMERICAN JOURNAL OF THERAPEUTICS

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

(2011) R. F. Machado et al.   BLOOD

Echocardiographic Markers of Elevated Pulmonary Pressure and Left Ventricular Diastolic Dysfunction Are Associated With Exercise Intolerance in Adults and Adolescents With Homozygous Sickle Cell Anemia in the United States and United Kingdom

(2011) Vandana Sachdev et al.   CIRCULATION

Pulmonary hypertension diagnosed by right heart catheterisation in sickle cell disease

(2011) G. H. H. Fonseca et al.   EUROPEAN RESPIRATORY JOURNAL

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi Fujii Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme

(2011) Masato Katsuyama et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease

(2011) Florence Parent et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension

(2010) Revathi Rajkumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling

(2010) B. S. Zuckerbraun et al.   CARDIOVASCULAR RESEARCH

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

(2010) Eileen M. Bauer et al.   CARDIOVASCULAR RESEARCH

Sickle cell disease serum induces NADPH enzyme subunit expression and oxidant production in leukocytes

(2010) Camila B. Almeida et al.   Hematology

Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension

(2010) Cristhiaan D Ochoa et al.   Journal of Cardiothoracic Surgery

Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension

(2010) Patrick Crosswhite et al.   JOURNAL OF HYPERTENSION

Sickle-cell disease

(2010) David C Rees et al.   LANCET

Segmentation and quantification of pulmonary artery for noninvasive CT assessment of sickle cell secondary pulmonary hypertension

(2010) Marius George Linguraru et al.   MEDICAL PHYSICS

Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

(2010) Beate Fuchs et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Angiogenic and Inflammatory Markers of Cardiopulmonary Changes in Children and Adolescents with Sickle Cell Disease

(2009) Xiaomei Niu et al.   PLoS One

Pulmonary arterial hypertension and left‐sided heart disease in sickle cell disease: Clinical characteristics and association with soluble adhesion molecule expression

(2008) Elizabeth S. Klings et al.   AMERICAN JOURNAL OF HEMATOLOGY

Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves

(2008) Steven R. Lammers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia

(2008) Kristine D. Estrada et al.   Biomechanics and Modeling in Mechanobiology

Thrombospondins: from structure to therapeutics

(2008) J. S. Isenberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice

(2008) Lucia De Franceschi et al.   FASEB JOURNAL

Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses

(2008) Jeff S. Isenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension

(2008) Marc Humbert et al.   VASCULAR PHARMACOLOGY