Probenecid directly impairs activation of the canine P2X7 receptor

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120

(2017) Rebecca C. Allsopp et al.   Scientific Reports

Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development—Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

(2016) Katarina Truvé et al.   PLoS Genetics

Structural basis for subtype-specific inhibition of the P2X7 receptor

(2016) Akira Karasawa et al.   eLife

R270C polymorphism leads to loss of function of the canine P2X7 receptor

(2014) Mari Spildrejorde et al.   PHYSIOLOGICAL GENOMICS

Probenecid Blocks Human P2X7 Receptor-Induced Dye Uptake via a Pannexin-1 Independent Mechanism

(2014) Archana Bhaskaracharya et al.   PLoS One

Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567

(2013) Anindya Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X7R: A potential key regulator of acute gouty arthritis

(2013) Jin-Hui Tao et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Extracellular adenosine 5′-triphosphate and lipopolysaccharide induce interleukin-1β release in canine blood

(2013) Mari Spildrejorde et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms

(2013) Lin-Hua Jiang et al.   Frontiers in Pharmacology

P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells

(2012) Safina Gadeock et al.   Purinergic Signalling

Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells

(2012) Iman Jalilian et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes

(2012) Iman Jalilian et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

The History and Future of Probenecid

(2011) Nathan Robbins et al.   Cardiovascular Toxicology

Cloning and pharmacological characterization of the dog P2X7 receptor

(2009) S Roman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanism of action of species-selective P2X7 receptor antagonists

(2009) Anton D Michel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

(2009) Diana L Donnelly-Roberts et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The P2X7 receptor mediates the uptake of organic cations in canine erythrocytes and mononuclear leukocytes: comparison to equivalent human cell types

(2009) Ryan O. Stevenson et al.   Purinergic Signalling

Probenecid, a gout remedy, inhibits pannexin 1 channels

(2008) William Silverman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Diverse Subcellular Distribution Profiles of Pannexin1 and Pannexin3

(2008) Silvia Penuela et al.   CELL COMMUNICATION AND ADHESION

Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

(2008) W. Ma et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cloning and pharmacological characterization of the guinea pig P2X7receptor orthologue

(2007) E Fonfria et al.   BRITISH JOURNAL OF PHARMACOLOGY