Acetylation of 53BP1 dictates the DNA double strand break repair pathway

The p53-binding protein 1-Tudor-interacting repair regulator complex participates in the DNA damage response

(2017) Aili Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18

(2017) Qi Hu et al.   MOLECULAR CELL

TIRR regulates 53BP1 by masking its histone methyl-lysine binding function

(2017) Pascal Drané et al.   NATURE

Dual-utility NLS drives RNF169-dependent DNA damage responses

(2017) Liwei An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

(2016) H. Jane Dyson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode

(2016) Donglai Wang et al.   NATURE

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy

(2015) Kristy R. Stengel et al.   ANTIOXIDANTS & REDOX SIGNALING

Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

(2015) Takayo Fukuda et al.   CANCER SCIENCE

Accessing DNA damage in chromatin: Preparing the chromatin landscape for base excision repair

(2015) Yesenia Rodriguez et al.   DNA REPAIR

REV7/MAD2L2: the multitasking maestro emerges as a barrier to recombination

(2015) J. E. Sale   EMBO JOURNAL

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells

(2015) Emilie Renaud et al.   NUCLEIC ACIDS RESEARCH

PTIP associates with Artemis to dictate DNA repair pathway choice

(2014) Jiadong Wang et al.   GENES & DEVELOPMENT

A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint

(2014) Tongzheng Liu et al.   MOLECULAR CELL

Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks

(2014) Dong-Hyun Lee et al.   MOLECULAR CELL

The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy

(2014) M Li et al.   ONCOGENE

UbcH7 regulates 53BP1 stability and DSB repair

(2014) Xiangzi Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair

(2014) Yu Zhao et al.   TRENDS IN CELL BIOLOGY

The 53BP1-EXPAND1 connection in chromatin structure regulation

(2014) Shirley M. H. Sy et al.   Nucleus

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

(2013) Elsa Callen et al.   CELL

DNA repair pathway choice—a PTIP of the hat to 53BP1

(2013) Cristina Escribano-Diaz et al.   EMBO REPORTS

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Push back to respond better: regulatory inhibition of the DNA double-strand break response

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

(2013) M. Bohgaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

53BP1: pro choice in DNA repair

(2013) Michal Zimmermann et al.   TRENDS IN CELL BIOLOGY

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

(2012) Frédérick A Mallette et al.   EMBO JOURNAL

Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage

(2012) Jie Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks

(2012) Maria Poulsen et al.   JOURNAL OF CELL BIOLOGY

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

(2011) Klara Acs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1

(2010) Michael S.Y. Huen et al.   MOLECULAR CELL

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation

(2010) Abderrahmane Kaidi et al.   SCIENCE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE