Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B

APOBEC2 negatively regulates myoblast differentiation in muscle regeneration

(2017) Hideaki Ohtsubo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization

(2017) Madison B. Adolph et al.   NUCLEIC ACIDS RESEARCH

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate

(2017) Stefan Harjes et al.   NUCLEIC ACIDS RESEARCH

Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation

(2017) Xiao Xiao et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

(2017) Takahide Kouno et al.   Nature Communications

A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger’s CATalytic Pocket

(2017) Justin J. King et al.   Frontiers in Immunology

Progressive APOBEC3B mRNA expression in distant breast cancer metastases

(2017) Anieta M. Sieuwerts et al.   PLoS One

B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers

(2017) Wen-Cheng Chou et al.   Scientific Reports

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

(2016) In-Ja L. Byeon et al.   BIOCHEMISTRY

APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines

(2016) Onder Onguru et al.   BIOMEDICINE & PHARMACOTHERAPY

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

Evidence for APOBEC3B mRNA and protein expression in oral squamous cell carcinomas

(2016) Galinos Fanourakis et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

(2016) Vladimir B. Seplyarskiy et al.   GENOME RESEARCH

APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma

(2016) Keisuke Kosumi et al.   MEDICAL ONCOLOGY

New Insights into the Mechanism of DNA Duplication by the Eukaryotic Replisome

(2016) Luca Pellegrini et al.   TRENDS IN BIOCHEMICAL SCIENCES

The APOBEC Protein Family: United by Structure, Divergent in Function

(2016) Jason D. Salter et al.   TRENDS IN BIOCHEMICAL SCIENCES

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

(2016) Gabriel J. Starrett et al.   Nature Communications

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

(2016) James I. Hoopes et al.   Cell Reports

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

(2016) E. K. Law et al.   Science Advances

Clusters of Multiple Mutations: Incidence and Molecular Mechanisms

(2015) Kin Chan et al.   Annual Review of Genetics

DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B

(2015) Y. Fu et al.   BIOCHEMICAL JOURNAL

Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability

(2015) Yuqing Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

(2015) Ke Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine

(2015) Sachini U. Siriwardena et al.   JOURNAL OF MOLECULAR BIOLOGY

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization

(2015) Markus-Frederik Bohn et al.   STRUCTURE

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages

(2015) Shraddha Sharma et al.   Nature Communications

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies

(2015) Luda S. Shlyakhtenko et al.   Scientific Reports

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions

(2015) Marat D. Kazanov et al.   Cell Reports

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

(2015) Manikandan Periyasamy et al.   Cell Reports

Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

(2015) Artem G. Lada et al.   PLoS Genetics

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

(2015) Catherine E. Waters et al.   Oncotarget

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Diffusion of Human Replication Protein A along Single-Stranded DNA

(2014) Binh Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Positive and negative impacts of nonspecific sites during target location by a sequence-specific DNA-binding protein: origin of the optimal search at physiological ionic strength

(2014) Alexandre Esadze et al.   NUCLEIC ACIDS RESEARCH

Concentration-Dependent Exchange of Replication Protein A on Single-Stranded DNA Revealed by Single-Molecule Imaging

(2014) Bryan Gibb et al.   PLoS One

Interaction of APOBEC3A with DNA Assessed by Atomic Force Microscopy

(2014) Luda S. Shlyakhtenko et al.   PLoS One

Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria

(2014) Aziz El Hage et al.   PLoS Genetics

Different Mutagenic Potential of HIV-1 Restriction Factors APOBEC3G and APOBEC3F Is Determined by Distinct Single-Stranded DNA Scanning Mechanisms

(2014) Anjuman Ara et al.   PLoS Pathogens

DNA Translocation by Human Uracil DNA Glycosylase: The Case of Single-Stranded DNA and Clustered Uracils

(2013) Joseph D. Schonhoft et al.   BIOCHEMISTRY

APOBEC3B Upregulation and Genomic Mutation Patterns in Serous Ovarian Carcinoma

(2013) B. Leonard et al.   CANCER RESEARCH

A Biochemical Analysis Linking APOBEC3A to Disparate HIV-1 Restriction and Skin Cancer

(2013) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Viral Infectivity Factor (Vif) Alters Processive Single-stranded DNA Scanning of the Retroviral Restriction Factor APOBEC3G

(2013) Yuqing Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atomic force microscopy studies of APOBEC3G oligomerization and dynamics

(2013) Luda S. Shlyakhtenko et al.   JOURNAL OF STRUCTURAL BIOLOGY

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties

(2013) M. Mitra et al.   NUCLEIC ACIDS RESEARCH

D316 is critical for the enzymatic activity and HIV-1 restriction potential of human and rhesus APOBEC3B

(2013) Rebecca M. McDougle et al.   VIROLOGY

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

Single-stranded DNA Scanning and Deamination by APOBEC3G Cytidine Deaminase at Single Molecule Resolution

(2012) Gayan Senavirathne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Analysis of Hypermutation by the Deoxycytidine Deaminase APOBEC3A

(2012) Robin P. Love et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOBEC3B and AID Have Similar Nuclear Import Mechanisms

(2012) Lela Lackey et al.   JOURNAL OF MOLECULAR BIOLOGY

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

APOBEC3A can activate the DNA damage response and cause cell-cycle arrest

(2011) Sébastien Landry et al.   EMBO REPORTS

Intensity of Deoxycytidine Deamination of HIV-1 Proviral DNA by the Retroviral Restriction Factor APOBEC3G Is Mediated by the Noncatalytic Domain

(2011) Yuqing Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

Analysis of Human APOBEC3H Haplotypes and Anti-Human Immunodeficiency Virus Type 1 Activity

(2011) X. Wang et al.   JOURNAL OF VIROLOGY

Replication Protein A (RPA) Hampers the Processive Action of APOBEC3G Cytosine Deaminase on Single-Stranded DNA

(2011) Artem G. Lada et al.   PLoS One

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

(2011) R. Suspene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription

(2011) Judith G Levin et al.   RNA Biology

Detection of Damaged DNA Bases by DNA Glycosylase Enzymes

(2010) Joshua I. Friedman et al.   BIOCHEMISTRY

Atomic Force Microscopy Studies Provide Direct Evidence for Dimerization of the HIV Restriction Factor APOBEC3G

(2010) Luda S. Shlyakhtenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Model for Deoxycytidine Deamination Mechanisms of the HIV-1 Inactivation Enzyme APOBEC3G

(2010) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Reptilian APOBEC1 Suggests that RNA Editing May Not Be Its Ancestral Function

(2010) Francesco Severi et al.   MOLECULAR BIOLOGY AND EVOLUTION

Reverse transcriptase in motion: Conformational dynamics of enzyme–substrate interactions

(2009) Matthias Götte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Deficiency in APOBEC2 Leads to a Shift in Muscle Fiber Type, Diminished Body Mass, and Myopathy

(2009) Yusuke Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination

(2009) Bao Q Vuong et al.   NATURE IMMUNOLOGY

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity

(2009) Meng Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-Dependent Oligomerization of APOBEC3G Is Required for Restriction of HIV-1

(2009) Hendrik Huthoff et al.   PLoS Pathogens

The Biochemistry of Somatic Hypermutation

(2008) Jonathan U. Peled et al.   Annual Review of Immunology

Antiretroelement Activity of APOBEC3H Was Lost Twice in Recent Human Evolution

(2008) Molly OhAinle et al.   Cell Host & Microbe

Impact of Phosphorylation and Phosphorylation-null Mutants on the Activity and Deamination Specificity of Activation-induced Cytidine Deaminase

(2008) Phuong Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Model for Oligomeric Regulation of APOBEC3G Cytosine Deaminase-dependent Restriction of HIV

(2008) Linda Chelico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY