The Ties That Bind: Mapping the Dynamic Enhancer-Promoter Interactome

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage-and celltype-specific dynamics of interactions between regulators and gene promoters.