Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation

Effectiveness and Harms of Recombinant Human Bone Morphogenetic Protein-2 in Spine Fusion

(2013) Rongwei Fu et al.   ANNALS OF INTERNAL MEDICINE

Mitogen-Activated Protein Kinase Pathways in Osteoblasts

(2013) Matthew B. Greenblatt et al.   Annual Review of Cell and Developmental Biology

Inflammatory Cytokines Induce a Unique Mineralizing Phenotype in Mesenchymal Stem Cells Derived from Human Bone Marrow

(2013) Elisabeth Ferreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein 2 on Cranial Defect Closure in the Pediatric Population

(2013) Omar E. Beidas et al.   JOURNAL OF CRANIOFACIAL SURGERY

BMP-2 Adverse Reactions Treated With Human Dose Equivalent Dexamethasone in a Rodent Model of Soft-Tissue Inflammation

(2013) Chengjie Xiong et al.   SPINE

Characterizing the Host Response to rhBMP-2 in a Rat Spinal Arthrodesis Model

(2013) Wellington K. Hsu et al.   SPINE

Contralateral psoas seroma after transpsoas lumbar interbody fusion with bone morphogenetic protein-2 implantation

(2013) Fadi Taher et al.   Spine Journal

LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NF-κB and BMP/Smad Signaling

(2013) Ru-Lin Huang et al.   STEM CELLS AND DEVELOPMENT

Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) in posterolateral lumbar spine fusion: complications in the elderly

(2013) Martin F Hoffmann et al.   Journal of Orthopaedic Surgery and Research

DMH1, a Highly Selective Small Molecule BMP Inhibitor Promotes Neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 Expression during Neural Induction

(2012) M. Diana Neely et al.   ACS Chemical Neuroscience

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

(2012) Guiqian Chen et al.   International Journal of Biological Sciences

Transient Soft-Tissue Edema Associated with Implantation of Increasing Doses of rhBMP-2 on an Absorbable Collagen Sponge in an Ectopic Rat Model

(2012) Hyun W. Bae et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104

(2012) Yi-Feng Huang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis

(2012) Nan Yang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BMP induced inflammation: A comparison of rhBMP-7 and rhBMP-2

(2012) Kwang-Bok Lee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells

(2012) Ada Ao et al.   PLoS One

The Effect of Corticosteroid Administration on Soft-Tissue Inflammation Associated With rhBMP-2 Use in a Rodent Model of Inflammation

(2012) Yanlin Tan et al.   SPINE

Activated NF-κB in Bone Marrow Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients Inhibits Osteogenic Differentiation Through Downregulating Smad Signaling

(2012) Yu Tang et al.   STEM CELLS AND DEVELOPMENT

Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration

(2011) Juthamas Ratanavaraporn et al.   BIOMATERIALS

Effects of inflammatory and anti-inflammatory cytokines on the bone

(2011) Georg Schett   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Exaggerated Inflammatory Response and Bony Resorption From BMP-2 Use in a Pediatric Forearm Nonunion

(2011) Andrew W. Ritting et al.   JOURNAL OF HAND SURGERY-AMERICAN VOLUME

Exaggerated Inflammatory Response After Use of Recombinant Bone Morphogenetic Protein in Recurrent Unicameral Bone Cysts

(2011) Kevin M. MacDonald et al.   JOURNAL OF PEDIATRIC ORTHOPAEDICS

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

TNF-  promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells

(2011) G. E. Glass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Characteristics of rhBMP-2 In Vitro and in an In Vivo Rodent Model

(2011) Kwang-Bok Lee et al.   SPINE

Bone morphogenetic protein–binding peptide reduces the inflammatory response to recombinant human bone morphogenetic protein-2 and recombinant human bone morphogenetic protein-7 in a rodent model of soft-tissue inflammation

(2011) Kwang-Bok Lee et al.   Spine Journal

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

(2011) Eugene J. Carragee et al.   Spine Journal

BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing p300 Levels and Histone Acetyltransferase Activity

(2010) Ji Hae Jun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of c-Jun NH2-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor

(2010) Hui Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Trauma-Induced Inflammation and Fracture Healing

(2010) Hans-Christophe Pape et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Estrogen and glucocorticoid regulate osteoblast differentiation through the interaction of bone morphogenetic protein-2 and tumor necrosis factor-α in C2C12 cells

(2010) Yoshinori Matsumoto et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts

(2010) Hiroyuki Eda et al.   RHEUMATOLOGY INTERNATIONAL

Cytokine-Mediated Inflammatory Reaction Following Posterior Cervical Decompression and Fusion Associated With Recombinant Human Bone Morphogenetic Protein-2

(2010) Brett N. Robin et al.   SPINE

A COMPREHENSIVE REVIEW OF THE SAFETY PROFILE OF BONE MORPHOGENETIC PROTEIN IN SPINE SURGERY

(2010) David Benglis et al.   Operative Neurosurgery

TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway

(2009) Katrin Hess et al.   BONE

BMP2 signaling in bone development and repair

(2009) Vicki Rosen   CYTOKINE & GROWTH FACTOR REVIEWS

Prevalence, Complications, and Hospital Charges Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion Procedures

(2009) Kevin S. Cahill   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tumor Necrosis Factor α Represses Bone Morphogenetic Protein (BMP) Signaling by Interfering with the DNA Binding of Smads through the Activation of NF-κB

(2009) Masato Yamazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-Inflammatory Cytokines TNF-Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen-Activated Protein Kinase (MAPK)-Dependent Expression of Sclerostin in Human Osteoblasts*

(2009) Cristina Vincent et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Simvastatin antagonizes tumor necrosis factor-α inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway

(2008) Misuzu Yamashita et al.   JOURNAL OF ENDOCRINOLOGY

Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation

(2008) D.C. Lacey et al.   OSTEOARTHRITIS AND CARTILAGE