A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol and defense pathways

GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua

(2016) Minghui Chen et al.   NEW PHYTOLOGIST

A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus

(2016) Priyanka Paul et al.   NEW PHYTOLOGIST

Over-expression ofDXSgene enhances terpenoidal secondary metabolite accumulation in rose-scented geranium andWithania somnifera: active involvement of plastid isoprenogenic pathway in their biosynthesis

(2016) Jyoti Singh Jadaun et al.   PHYSIOLOGIA PLANTARUM

Jasmonate-Responsive ERF Transcription Factors Regulate Steroidal Glycoalkaloid Biosynthesis in Tomato

(2016) Chonprakun Thagun et al.   PLANT AND CELL PHYSIOLOGY

Nitrogen treatment enhances sterols and withaferin A through transcriptional activation of jasmonate pathway, WRKY transcription factors, and biosynthesis genes in Withania somnifera (L.) Dunal

(2016) Shaifali Pal et al.   PROTOPLASMA

GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway

(2016) Pablo D. Cárdenas et al.   Nature Communications

Silencing of sterol glycosyltransferases modulates the withanolide biosynthesis and leads to compromised basal immunity of Withania somnifera

(2016) Gaurav Singh et al.   Scientific Reports

RNAi and Homologous Over-Expression Based Functional Approaches Reveal Triterpenoid Synthase Gene-Cycloartenol Synthase Is Involved in Downstream Withanolide Biosynthesis in Withania somnifera

(2016) Smrati Mishra et al.   PLoS One

Virus-induced gene silencing ofWithania somniferasqualene synthase negatively regulates sterol and defence-related genes resulting in reduced withanolides and biotic stress tolerance

(2015) Anup Kumar Singh et al.   PLANT BIOTECHNOLOGY JOURNAL

The bHLH Transcription Factors TSAR1 and TSAR2 Regulate Triterpene Saponin Biosynthesis in Medicago truncatula

(2015) Jan Mertens et al.   PLANT PHYSIOLOGY

Precursor feeding studies and molecular characterization of geraniol synthase establish the limiting role of geraniol in monoterpene indole alkaloid biosynthesis in Catharanthus roseus leaves

(2015) Krishna Kumar et al.   PLANT SCIENCE

Light and auxin responsive cytochrome P450s from Withania somnifera Dunal: cloning, expression and molecular modelling of two pairs of homologue genes with differential regulation

(2015) Sudhakar Srivastava et al.   PROTOPLASMA

Plasticity of specialized metabolism as mediated by dynamic metabolons

(2015) Tomas Laursen et al.   TRENDS IN PLANT SCIENCE

Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations

(2014) Satiander Rana et al.   BMC BIOTECHNOLOGY

RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters

(2014) Eleni A Spyropoulou et al.   BMC GENOMICS

Cloning and Functional Characterization of Three Branch Point Oxidosqualene Cyclases fromWithania somnifera(L.) Dunal

(2014) Niha Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of macronutrient deficiency on withanolides content in the roots ofWithania somniferaand its correlationship with molybdenum content

(2014) Santosh T. Devkar et al.   PHARMACEUTICAL BIOLOGY

Sterol partitioning byHMGRandDXRfor routing intermediates toward withanolide biosynthesis

(2014) Shefali Singh et al.   PHYSIOLOGIA PLANTARUM

WRKY45-dependent priming of diterpenoid phytoalexin biosynthesis in rice and the role of cytokinin in triggering the reaction

(2014) Aya Akagi et al.   PLANT MOLECULAR BIOLOGY

Regulation of Specialized Metabolism by WRKY Transcription Factors

(2014) Craig Schluttenhofer et al.   PLANT PHYSIOLOGY

Plant Oxidosqualene Metabolism: Cycloartenol Synthase–Dependent Sterol Biosynthesis in Nicotiana benthamiana

(2014) Elisabet Gas-Pascual et al.   PLoS One

Investigation of triterpene synthesis and regulation in oats reveals a role for  -amyrin in determining root epidermal cell patterning

(2014) A. C. Kemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0

(2013) Koichiro Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis

(2013) Avanish Rai et al.   Molecular Plant

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biologyin vivoandin vitro

(2013) Tessa Moses et al.   NEW PHYTOLOGIST

Discovery of WRKY transcription factors through transcriptome analysis and characterization of a novel methyl jasmonate-inducible PqWRKY1 gene from Panax quinquefolius

(2013) Yongzhen Sun et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Characterization of HbWRKY1, a WRKY transcription factor from Hevea brasiliensis that negatively regulates HbSRPP

(2013) Ying Wang et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Accumulation of a bioactive triterpene saponin fraction of Quillaja brasiliensis leaves is associated with abiotic and biotic stresses

(2013) Fernanda de Costa et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal

(2012) Wajid Waheed Bhat et al.   GENE

Molecular characterization and promoter analysis of squalene epoxidase gene from Withania somnifera (L.) Dunal

(2012) Sumeer Razdan et al.   MOLECULAR BIOLOGY REPORTS

Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene inTaxus chinensis

(2012) S. Li et al.   PLANT BIOLOGY

Engineering triterpene metabolism in tobacco

(2012) Shuiqin Wu et al.   PLANTA

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis of Cholesterol and Other Sterols

(2011) W. David Nes   CHEMICAL REVIEWS

Molecular activities, biosynthesis and evolution of triterpenoid saponins

(2011) Jörg M. Augustin et al.   PHYTOCHEMISTRY

Overexpression of Brassica juncea wild-type and mutant HMG-CoA synthase 1 in Arabidopsis up-regulates genes in sterol biosynthesis and enhances sterol production and stress tolerance

(2011) Hui Wang et al.   PLANT BIOTECHNOLOGY JOURNAL

Phosphorylation of the Nicotiana benthamiana WRKY8 Transcription Factor by MAPK Functions in the Defense Response

(2011) N. Ishihama et al.   PLANT CELL

The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

(2011) N. Suttipanta et al.   PLANT PHYSIOLOGY

Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species

(2011) Eun-Ryeong Hahm et al.   PLoS One

Expression profiling of HbWRKY1, an ethephon-induced WRKY gene in latex from Hevea brasiliensis in responding to wounding and drought

(2011) Quanqi Zhang et al.   TREES-STRUCTURE AND FUNCTION

Brassinosteroid-mediated stress tolerance in Arabidopsis shows interactions with abscisic acid, ethylene and salicylic acid pathways

(2010) Uday K Divi et al.   BMC PLANT BIOLOGY

Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis

(2010) S. Koduru et al.   MOLECULAR CANCER THERAPEUTICS

High throughput screening of mutants of oat that are defective in triterpene synthesis

(2010) Bo Qin et al.   PHYTOCHEMISTRY

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

(2009) Mohammad Mirjalili et al.   MOLECULES

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

(2009) Dongming Ma et al.   PLANT AND CELL PHYSIOLOGY

An efficient chromatin immunoprecipitation (ChIP) protocol for studying histone modifications in Arabidopsis plants

(2008) Abdelaty Saleh et al.   Nature Protocols

Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera)

(2008) Rajender Singh Sangwan et al.   PHYSIOLOGIA PLANTARUM

Two nearly identical terpene synthases catalyze the formation of nerolidol and linalool in snapdragon flowers

(2008) Dinesh A. Nagegowda et al.   PLANT JOURNAL