Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats

General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus

(2016) Lorenza Dalla Massara et al.   ANESTHESIOLOGY

Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspringviathe BDNF-TrkB signalling pathway

(2016) Liang Zhong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure

(2016) Jing Li et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats

(2016) Bo Chen et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Does age matter? The impact of rodent age on study outcomes

(2016) Samuel J Jackson et al.   LABORATORY ANIMALS

Propofol, but not etomidate, increases corticosterone levels and induces long-term alteration in hippocampal synaptic activity in neonatal rats

(2016) Changqing Xu et al.   NEUROSCIENCE LETTERS

The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats

(2016) Desanka Milanovic et al.   NEUROTOXICITY RESEARCH

Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

(2016) Sung-Soo Jang et al.   NEURAL PLASTICITY

Functional Evaluations of Genes Disrupted in Patients with Tourette’s Disorder

(2016) Nawei Sun et al.   Frontiers in Psychiatry

Repeated Exposure to Ketamine–Xylazine during Early Development Impairs Motor Learning–dependent Dendritic Spine Plasticity in Adulthood

(2015) Lianyan Huang et al.   ANESTHESIOLOGY

Repeated Neonatal Propofol Administration Induces Sex-Dependent Long-Term Impairments on Spatial and Recognition Memory in Rats

(2015) Edson Luck T. Gonzales et al.   Biomolecules & Therapeutics

Detrimental effects of postnatal exposure to propofol on memory and hippocampal LTP in mice

(2015) Yuan-Lin Wang et al.   BRAIN RESEARCH

Neonatal propofol anesthesia modifies activity-dependent processes and induces transient hyperlocomotor response to d-amphetamine during adolescence in rats

(2015) Vesna Pešić et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum

(2015) N. Lunardi et al.   MOLECULAR NEUROBIOLOGY

Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo

(2015) Takahiko Chimura et al.   PLoS One

Propofol anesthesia induces proapoptotic tumor necrosis factor-α and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain

(2014) Desanka Milanović et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Isoflurane Reversibly Destabilizes Hippocampal Dendritic Spines by an Actin-Dependent Mechanism

(2014) Jimcy Platholi et al.   PLoS One

The roles of protein expression in synaptic plasticity and memory consolidation

(2014) Tali Rosenberg et al.   Frontiers in Molecular Neuroscience

Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar

(2013) V Jevtovic-Todorovic et al.   BRITISH JOURNAL OF ANAESTHESIA

Maternal Endotoxin Exposure Results in Abnormal Neuronal Architecture in the Newborn Rabbit

(2013) Bindu Balakrishnan et al.   DEVELOPMENTAL NEUROSCIENCE

The Novel Caspase-3 Substrate Gap43 is Involved in AMPA Receptor Endocytosis and Long-Term Depression

(2013) Meng-Hsuan Han et al.   MOLECULAR & CELLULAR PROTEOMICS

Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats

(2013) Deshui Yu et al.   NEUROSCIENCE LETTERS

Repeated exposure to propofol impairs spatial learning, inhibits LTP and reduces CaMKIIα in young rats

(2013) Jin Gao et al.   NEUROSCIENCE LETTERS

Effect of Propofol in the Immature Rat Brain on Short- and Long-Term Neurodevelopmental Outcome

(2013) Tanja Karen et al.   PLoS One

N-Cadherin Relocalizes from the Periphery to the Center of the Synapse after Transient Synaptic Stimulation in Hippocampal Neurons

(2013) Patricia T. Yam et al.   PLoS One

Developmental neuroplasticity and the origin of neurodegenerative diseases

(2013) Andrea T. U. Schaefers et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Isoflurane suppresses early cortical activity

(2013) Guzel Sitdikova et al.   Annals of Clinical and Translational Neurology

General Anesthesia

(2012) Laszlo Vutskits   ANESTHESIA AND ANALGESIA

Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats

(2012) Jennifer Shih et al.   ANESTHESIOLOGY

What does the developing brain tell us about neural diseases?

(2012) Esther T. Stoeckli   EUROPEAN JOURNAL OF NEUROSCIENCE

N-Cadherin Prodomain Processing Regulates Synaptogenesis

(2012) A. Reines et al.   JOURNAL OF NEUROSCIENCE

Attention-Deficit/Hyperactivity Disorder After Early Exposure to Procedures Requiring General Anesthesia

(2012) Juraj Sprung et al.   MAYO CLINIC PROCEEDINGS

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain

(2011) Victoria Sanchez et al.   ANESTHESIOLOGY

Developmental Stage-dependent Persistent Impact of Propofol Anesthesia on Dendritic Spines in the Rat Medial Prefrontal Cortex

(2011) Adrian Briner et al.   ANESTHESIOLOGY

Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation

(2011) Matthew L. Pearn et al.   ANESTHESIOLOGY

Neurodevelopmental movement disorders - an update on childhood motor stereotypies

(2011) SINÉAD BARRY et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Beyond Anesthetic Properties: The Effects of Isoflurane on Brain Cell Death, Neurogenesis, and Long-Term Neurocognitive Function

(2010) Greg Stratmann et al.   ANESTHESIA AND ANALGESIA

Timing versus duration

(2010) Sabina Rizzi et al.   Annals of the New York Academy of Sciences

Sensory features and repetitive behaviors in children with autism and developmental delays

(2010) Brian A. Boyd et al.   Autism Research

Is there any relationship between long-term behavior disturbance and early exposure to anesthesia?

(2010) Robert T Wilder   Current Opinion in Anesthesiology

Regional and Temporal Profiles of Calpain and Caspase-3 Activities in Postnatal Rat Brain following Repeated Propofol Administration

(2010) Desanka Milanovic et al.   DEVELOPMENTAL NEUROSCIENCE

N-cadherin mediates plasticity-induced long-term spine stabilization

(2010) Pablo Mendez et al.   JOURNAL OF CELL BIOLOGY

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems

(2010) Evelyne Sernagor   Frontiers in Cellular Neuroscience

N-cadherin prodomain cleavage regulates synapse formationin vivo

(2009) Nazlie S. Latefi et al.   Developmental Neurobiology

Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons

(2009) A. Ivanov et al.   JOURNAL OF CELL SCIENCE

Calpain-Mediated N-Cadherin Proteolytic Processing in Brain Injury

(2009) Y.-N. Jang et al.   JOURNAL OF NEUROSCIENCE

Neurodegeneration in Newborn Rats Following Propofol and Sevoflurane Anesthesia

(2009) Sven Bercker et al.   NEUROTOXICITY RESEARCH

Anesthetics Rapidly Promote Synaptogenesis during a Critical Period of Brain Development

(2009) Mathias De Roo et al.   PLoS One

Motor Stereotypies

(2009) Harvey S. Singer   Seminars in Pediatric Neurology

Propofol causes neurite retraction in neurones

(2008) D. Turina et al.   BRITISH JOURNAL OF ANAESTHESIA

Cadherins and synaptic plasticity

(2008) Chin-Yin Tai et al.   CURRENT OPINION IN CELL BIOLOGY

Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia

(2008) Vesna Pešić et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE