Article
Anesthesiology
Jiajia Ma, Wei Xiong, Dongze Guo, Anxin Wang, Hui Qiao, Ruquan Han
Summary: The study compares the effect of sevoflurane-propofol-balanced anesthesia with propofol-based total intravenous anesthesia on the amplitude of FVEP during spine surgery. The results show that the effect of sevoflurane-propofol-balanced anesthesia on FVEP amplitude is noninferior to propofol-based TIVA under comparable BIS range.
ANESTHESIA AND ANALGESIA
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xia Li, Yali Liu, Chengjun Li, Jiexue Wang
Summary: This study found through meta-analysis that nitrous oxide inhalation is an effective sedative and analgesic treatment during tooth extraction, and oral midazolam can be used as an alternative to nitrous oxide inhalation.
Article
Cell Biology
Yanqiong Wu, Zeyong Yang, Shanchun Su, Xueqin Xu, Yang Li, Xiaohui Li, Yan Gao, Dongsheng Sun, Shengjun Wan, Mingjin Pen, Weiling Jin, Changbin Ke
Summary: This study reveals that repeated early-life exposure to anesthetics can disrupt neurodevelopment and affect social behaviors. The m6A modification plays a crucial role in this process, and anesthetics lead to persistent alterations in protein expression and brain function.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hiroyuki Saito, Ryuichi Kambayashi, Mihoko Hagiwara-Nagasawa, Yoshio Nunoi, Ai Goto, Hiroko Izumi-Nakaseko, Shinichi Kawai, Yoshinori Takei, Akio Matsumoto, Kiyotaka Hoshiai, Yasuki Akie, Atsushi Sugiyama
Summary: The study compared the electrocardiographic responses induced by dl-sotalol in intact dogs under different anesthetic states, revealing differences in sympathetic nerve suppression between halothane and isoflurane with nitrous oxide. Both anesthetics exhibited similar effects on ventricular ion channel inhibition, but differed in their influence on the atrioventricular node.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Longfei Wang, Qiuyue Wu, Ming Wang, Wanquan Ming, Cheng Sheng, Yonghua Zhang, Yongbin Chen, Yunfei Cao
Summary: This study aimed to assess the safety and efficacy of midazolam combined with different doses of alfentanil in DFB sedation. The results showed that higher doses of alfentanil combined with a fixed low dose of midazolam significantly reduced discomfort and improved patient satisfaction during DFB, without increasing the risk of desaturation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Petra Dmitrovic, Jana Vanaga, Julien Dupont, Thierry Franck, Alexandra Gougnard, Johann Detilleux, Liga Kovalcuka, Alexandra Salciccia, Didier Serteyn, Charlotte Sandersen
Summary: The study aimed to investigate the effect of fentanyl on various parameters during equine general anaesthesia, showing that horses in the fentanyl group required a significantly lower dose of additional ketamine to maintain sufficient depth of anaesthesia, and had significantly higher PTA values.
Article
Geosciences, Multidisciplinary
Weiyi Tang, Amal Jayakumar, Xin Sun, John C. Tracey, Julia Carroll, Elizabeth Wallace, Jenna A. Lee, Levy Nathan, Bess Ward
Summary: The study found that N2O consumption rates are high in the seasonally anoxic environment of Chesapeake Bay, but generally undetectable in oxygenated waters. However, when the oxygen concentration was reduced in oxygenated samples, N2O consumption rates increased significantly, indicating the potential for N2O consumption in oxygenated environments. These new observations provide insights into N2O cycling processes and can be used to improve the modeling of N2O flux in estuaries.
GEOPHYSICAL RESEARCH LETTERS
(2022)
Review
Pediatrics
Pyrola Backe, Matteo Bruschettini, Ylva Thernstrom Blomqvist, Greta Sibrecht, Emma Olsson
Summary: This systematic review aimed to evaluate the benefits and harms of pharmacological and non-pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia. The study found limited evidence and recommended further clinical trials to determine the most effective interventions in this population.
Article
Pediatrics
Roaa I. Alhaidari, Maha A. AlSarheed
Summary: The aim of this study was to evaluate the post-discharge effects of oral midazolam with intranasal fentanyl sedation in pediatric patients who had dental treatment and to evaluate parents' preference regarding sedation visits. The results showed that intranasal fentanyl added to oral midazolam sedation could have an effect on post-discharge adverse behavioral changes, prolonged sleeping, and prolonged recovery time. Children sedated with midazolam/fentanyl required a longer amount of time until the first meal. There was no difference in parents' preferences regarding the two sedation regimens.
Article
Environmental Sciences
Todd S. Rosenstock, Andreas Wilkes
Summary: Improving agricultural activity data is a cost-effective option for reducing the uncertainty of greenhouse gas inventories and monitoring mitigation actions, meeting multiple national data needs, and bolstering investments. It's time to direct effort to this opportunity.
NATURE CLIMATE CHANGE
(2021)
Review
Gastroenterology & Hepatology
Brian M. Fung, Deanna J. Leon, Lauren N. Beck, James H. Tabibian
Summary: Gastrointestinal endoscopy in patients with advanced liver disease poses challenges for procedural sedation, requiring careful consideration of sedative agent selection and individualized planning.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Agronomy
Do-Yeong Hur, Sung-Un Kim, Hyeon-Cheol Park, Keun-Ki Kim, Hong-Ju Son, Kwang-Min Lee, Yu-Jin Kim, Chang-Oh Hong
Summary: The study found that the application of bottom ash (BA) can reduce N2O emissions from upland arable soil and increase crop yield. With increasing BA application rates, N2O emissions decreased significantly and yield-scaled N2O emissions also decreased. The study suggests that an application rate of 200 Mg·ha(-1) of BA can reduce N2O emissions.
Article
Health Care Sciences & Services
Marina Rizzi, Francesco Panzera, Demetrio Panzera, Berardino D'Ascoli
Summary: Performing GI endoscopy under sedoanalgesia improves the quality of the examination, but regional barriers exist. This study demonstrates that personalized sedoanalgesia in GI endoscopy can be safely managed in selected patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Josephine L. Feliciano, Julie M. Waldfogel, Ritu Sharma, Allen Zhang, Arjun Gupta, Ramy Sedhom, Jeff Day, Eric B. Bass, Sydney M. Dy
Summary: This systematic review and meta-analysis included 19 studies evaluating pharmacologic interventions for breathlessness in patients with advanced cancer. The evidence did not support the association of opioids or other pharmacologic interventions with improved breathlessness. While pharmacologic interventions demonstrated some harms compared with usual care, dropout attributable to adverse events was minimal in these short-term studies.
Article
Oncology
Qiaoqin Yan, Bingbing Sheng, Xiaoyan Huang, Kang Lin, Jie Lin, Xianhua Ye
Summary: The clinical effect of different doses of midazolam combined with fentanyl during painless bronchoscopy in adult patients was investigated. The results showed that sedation with 0.05 mg/kg midazolam and 0.2 mu g/kg fentanyl had little effect on SpO2 levels and had a good sedative and anesthetic effect, reducing awaking time, restlessness response, and adverse reactions.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)