Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

Amyloid-β as a Modulator of Synaptic Plasticity

(2017) Mordhwaj S. Parihar et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses

(2015) Anna Wilkaniec et al.   JOURNAL OF NEUROCHEMISTRY

Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease

(2015) A. Megill et al.   JOURNAL OF NEUROSCIENCE

GRIP1 is required for homeostatic regulation of AMPAR trafficking

(2015) Han L. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade

(2015) Melanie A. Gainey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation regulates neuronal glutamatergic synaptic scaling

(2015) Jarrod P. Meadows et al.   Science Signaling

Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity

(2015) Sung-Soo Jang et al.   Molecular Brain

N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity

(2015) Kwan Lee et al.   Molecular Brain

DNA methylation regulates neuronal glutamatergic synaptic scaling

(2015) Jarrod P. Meadows et al.   Science Signaling

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

(2015) Josiane Budni et al.   Aging and Disease

SUMOylation: Novel Neuroprotective Approach for Alzheimer’s Disease?

(2015) Juliana B Hoppe et al.   Aging and Disease

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Synapto-depressive effects of amyloid beta require PICK1

(2014) Stephanie Alfonso et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

(2014) S. L. Scudder et al.   JOURNAL OF NEUROSCIENCE

miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling

(2014) Mathieu Letellier et al.   NATURE NEUROSCIENCE

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

(2014) Linda Lee et al.   Scientific Reports

Calcineurin Mediates Synaptic Scaling Via Synaptic Trafficking of Ca2+-Permeable AMPA Receptors

(2014) Seonil Kim et al.   PLOS BIOLOGY

Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2014) Jian Xu et al.   PLOS BIOLOGY

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners

(2013) Gareth M. Thomas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2013) B. F. Corbett et al.   JOURNAL OF NEUROSCIENCE

An Essential Role for Inhibitor-2 Regulation of Protein Phosphatase-1 in Synaptic Scaling

(2013) B. A. Siddoway et al.   JOURNAL OF NEUROSCIENCE

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity

(2013) O. A. Shipton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

C-terminal fragment of N-cadherin accelerates synapse destabilization by amyloid-β

(2012) Aksana Andreyeva et al.   BRAIN

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Regulation of AMPA receptor trafficking and synaptic plasticity

(2012) Victor Anggono et al.   CURRENT OPINION IN NEUROBIOLOGY

Homeostatic Synaptic Scaling Is Regulated by Protein SUMOylation

(2012) Tim J. Craig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MSK1 Regulates Homeostatic and Experience-Dependent Synaptic Plasticity

(2012) S. A. L. Correa et al.   JOURNAL OF NEUROSCIENCE

A Critical and Cell-Autonomous Role for MeCP2 in Synaptic Scaling Up

(2012) M. P. Blackman et al.   JOURNAL OF NEUROSCIENCE

Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration

(2012) Y.-D. Kwak et al.   JOURNAL OF NEUROSCIENCE

The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling

(2012) Z. Qiu et al.   JOURNAL OF NEUROSCIENCE

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

(2012) Seung Min Shin et al.   NATURE NEUROSCIENCE

The BCM theory of synapse modification at 30: interaction of theory with experiment

(2012) Leon N Cooper et al.   NATURE REVIEWS NEUROSCIENCE

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

(2012) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Pull-Push Neuromodulation of LTP and LTD Enables Bidirectional Experience-Induced Synaptic Scaling in Visual Cortex

(2012) ShiYong Huang et al.   NEURON

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

NMDA receptors and metaplasticity: Mechanisms and possible roles in neuropsychiatric disorders

(2012) Charles F. Zorumski et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurologic and motor dysfunctions in APP transgenic mice

(2012) Robert Lalonde et al.   REVIEWS IN THE NEUROSCIENCES

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

(2011) Jing Wu et al.   CELL

Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels

(2011) Sofya Ziyatdinova et al.   EPILEPSY RESEARCH

Compensatory redistribution of neuroligins and N-cadherin following deletion of synaptic β1-integrin

(2011) Steven Mortillo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

(2011) Megumi Asada-Utsugi et al.   JOURNAL OF NEUROCHEMISTRY

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

(2011) Amy Lin et al.   JOURNAL OF NEUROCHEMISTRY

PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down

(2011) Q. Sun et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2

(2011) M. P. Lussier et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

PICK1 Loss of Function Occludes Homeostatic Synaptic Scaling

(2011) V. Anggono et al.   JOURNAL OF NEUROSCIENCE

Differential control of presynaptic efficacy by postsynaptic N-cadherin and β-catenin

(2011) Nathalia Vitureira et al.   NATURE NEUROSCIENCE

A stabilising influence: Integrins in regulation of synaptic plasticity

(2011) Andrew B. McGeachie et al.   NEUROSCIENCE RESEARCH

Phosphorylation of AMPA Receptors Is Required for Sensory Deprivation-Induced Homeostatic Synaptic Plasticity

(2011) Anubhuti Goel et al.   PLoS One

CDK5 Is Essential for Soluble Amyloid β-Induced Degradation of GKAP and Remodeling of the Synaptic Actin Cytoskeleton

(2011) Francesco Roselli et al.   PLoS One

Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor

(2011) Y. Makino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Hippocampal synaptic metaplasticity requires the activation of NR2B-containing NMDA receptors

(2010) Qian Yang et al.   BRAIN RESEARCH BULLETIN

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

N-cadherin mediates plasticity-induced long-term spine stabilization

(2010) Pablo Mendez et al.   JOURNAL OF CELL BIOLOGY

A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61

(2010) P. Kurup et al.   JOURNAL OF NEUROSCIENCE

Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin

(2010) O. Bozdagi et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor-  Signaling Maintains the Ability of Cortical Synapses to Express Synaptic Scaling

(2010) C. C. Steinmetz et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway

(2010) L. A. Schwarz et al.   JOURNAL OF NEUROSCIENCE

APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

(2010) Amy K Y Fu et al.   NATURE NEUROSCIENCE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Functional Alterations in Memory Networks in Early Alzheimer’s Disease

(2010) Reisa A. Sperling et al.   NEUROMOLECULAR MEDICINE

Synapse-Specific Metaplasticity: To Be Silenced Is Not to Silence 2B

(2010) Benjamin D. Philpot et al.   NEURON

Unraveling Mechanisms of Homeostatic Synaptic Plasticity

(2010) Karine Pozo et al.   NEURON

Single-Cell Optogenetic Excitation Drives Homeostatic Synaptic Depression

(2010) Carleton P. Goold et al.   NEURON

Metaplasticity at Single Glutamatergic Synapses

(2010) Ming-Chia Lee et al.   NEURON

Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a

(2010) Jia-Hua Hu et al.   NEURON

Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

(2010) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Synaptic Mechanisms for Plasticity in Neocortex

(2009) Daniel E. Feldman   Annual Review of Neuroscience

Subunit-selective palmitoylation regulates the intracellular trafficking of AMPA receptor

(2009) Guang Yang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

(2009) Jun Noritake et al.   JOURNAL OF CELL BIOLOGY

Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression

(2009) Kyoko Kubota et al.   JOURNAL OF NEUROCHEMISTRY

Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus

(2009) Hey-Kyoung Lee et al.   JOURNAL OF NEUROPHYSIOLOGY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease

(2009) S. Peng et al.   JOURNAL OF NEUROSCIENCE

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Synaptic Scaling Requires the GluR2 Subunit of the AMPA Receptor

(2009) M. A. Gainey et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation

(2009) Da-Ting Lin et al.   NATURE NEUROSCIENCE

Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain

(2009) D.L. Vogt et al.   NEUROBIOLOGY OF AGING

Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin?

(2009) Jorge J. Palop et al.   NEUROMOLECULAR MEDICINE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Differential involvement of β3 integrin in pre- and postsynaptic forms of adaptation to chronic activity deprivation

(2009) Lorenzo A. Cingolani et al.   Neuron Glia Biology

Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid1-40 through Divergent NMDAR-Dependent Signalling Pathways

(2009) Francesco Roselli et al.   PLoS One

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation

(2009) K. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GluN2B subunit-containing NMDA receptor antagonists prevent A -mediated synaptic plasticity disruption in vivo

(2009) N.-W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

(2008) Gina G. Turrigiano   CELL

N-cadherin-based adhesion enhances Aβ release and decreases Aβ42/40ratio

(2008) Kengo Uemura et al.   JOURNAL OF NEUROCHEMISTRY

Retinoic Acid Attenuates  -Amyloid Deposition and Rescues Memory Deficits in an Alzheimer's Disease Transgenic Mouse Model

(2008) Y. Ding et al.   JOURNAL OF NEUROSCIENCE

Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity

(2008) D. P. Seeburg et al.   JOURNAL OF NEUROSCIENCE

The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation

(2008) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Metaplasticity: tuning synapses and networks for plasticity

(2008) Wickliffe C. Abraham   NATURE REVIEWS NEUROSCIENCE

Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1ΔE9-deleted transgenic mice model of β-amyloidosis

(2008) Arturas Volianskis et al.   NEUROBIOLOGY OF AGING

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

(2008) Ana-María Simón et al.   NEUROBIOLOGY OF DISEASE

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins

(2008) Lorenzo A. Cingolani et al.   NEURON

Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD

(2008) Sungjin Park et al.   NEURON

Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex

(2008) Megumi Kaneko et al.   NEURON

Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing

(2008) Keiji Ibata et al.   NEURON

Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity

(2008) Daniel P. Seeburg et al.   NEURON

Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity

(2008) Jason Aoto et al.   NEURON

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: Involvement of oxidative stress and mitogen-activated protein kinase cascades

(2008) M. Matos et al.   NEUROSCIENCE

Synapse elimination accompanies functional plasticity in hippocampal neurons

(2008) N. Bastrikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic acid regulates RAR -mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity

(2008) B. Maghsoodi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic acid-gated sequence-specific translational control by RAR 

(2008) M. M. Poon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE

Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1

(2007) I. Dewachter et al.   NEUROBIOLOGY OF AGING