Review
Biochemistry & Molecular Biology
Pietro Cacialli
Summary: This study examines the role of neurotrophins in zebrafish and mammals after TBI, revealing that while the reparative mechanisms in the mammalian brain are limited, adult fish brains have high regenerative properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Ziyi Xue, Min Shui, Xiaowan Lin, Yi Sun, Jianhui Liu, Changwei Wei, Anshi Wu, Tianzuo Li
Summary: This study demonstrates the critical role of the BDNF/proBDNF ratio in modulating synaptic plasticity and suggests it as a promising therapeutic target for PNCD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Claudia Gatta, Valentina Schiano, Chiara Attanasio, Carla Lucini, Antonio Palladino
Summary: In this study, the presence of neurotrophic factors in the taste bud cells of zebrafish is demonstrated. These neurotrophins play an important role in taste bud function and share similarities with those found in mammals. This study further confirms the significance of the zebrafish model in translational research.
Article
Biochemistry & Molecular Biology
Sarah Ateaque, Spyros Merkouris, Sean Wyatt, Nicholas D. Allen, Jia Xie, Peter S. DiStefano, Ronald M. Lindsay, Yves-Alain Barde
Summary: In the central nervous system, both NT3 and TrkC have unique roles in the assembly of neuronal circuits. NT3 activates TrkC at lower concentrations, but at high concentrations, it can also activate TrkB and down-regulate TrkC. These findings are important for understanding neurodevelopment and the pathogenesis of neurodegenerative diseases.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Chemistry, Medicinal
Tatiana A. Gudasheva, Polina Y. Povarnina, Aleksey V. Tarasiuk, Sergey B. Seredenin
Summary: This review discusses the efforts to create low-molecular-weight mimetics of neurotrophins NGF and BDNF with improved pharmacokinetic properties and lacking side effects. Various peptide and nonpeptide mimetics have been produced to mimic the therapeutic effects of full-sized proteins by targeting specific receptors. The relationship between the structure of these mimetics and their action mechanisms and pharmacological properties are analyzed, with special attention given to dipeptide mimetics and their activation of different signal transduction pathways. Promising compounds at different stages of preclinical and clinical studies are also summarized.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Mayra Colardo, Noemi Martella, Daniele Pensabene, Silvia Siteni, Sabrina Di Bartolomeo, Valentina Pallottini, Marco Segatto
Summary: Neurotrophins are a family of growth factors initially thought to primarily mediate nervous system development and neuronal survival, but increasing evidence suggests they also play crucial roles in regulating metabolic processes such as redox balance, glucose homeostasis, and cholesterol metabolism. This review examines the signaling pathways of neurotrophins and their impact on metabolism, particularly focusing on their effects on cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Umit Haluk Yesilkaya, Sakir Gica, Busra Guney Tasdemir, Pelin Ozkara Menekseoglu, Zeynep Cirakli, Nesrin Karamustafalioglu
Summary: The study suggests that an imbalance between pro-BDNF/mature BDNF and p75NTR/TrkB may contribute to the pathogenesis of synaptic pruning in psychotic disorders, with lower levels of mature BDNF, TrkB, and PAI-1, tPA, and higher levels of ACTH and cortisol observed in first-episode psychosis patients compared to healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Francesca Bonomini, Gaia Favero, Stefania Castrezzati, Elisa Borsani
Summary: Orofacial pain is a complex biomedical challenge without a satisfactory solution. This review evaluates the involvement of neurotrophins in orofacial nociception and their potential role as targets for pain modulation. Further studies are needed to clarify their application in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jing Wang, Yichen Cai, Jingyi Sun, Hua Feng, Xiaoyu Zhu, Qian Chen, Feng Gao, Qingbin Ni, Leilei Mao, Mingfeng Yang, Baoliang Sun
Summary: In this study, non-invasive treatment methods using AAV vectors carrying BDNF or TrkB genes were performed on stroke-injured rats. The combination therapy significantly improved upper limb motor functional recovery and neurotransmission efficiency, promoting axonal remodeling and restoration of synaptic structures.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Medicine, General & Internal
Carla Petrella, Raffaella Nenna, Laura Petrarca, Francesca Tarani, Roberto Paparella, Enrica Mancino, Greta Di Mattia, Maria Giulia Conti, Luigi Matera, Enea Bonci, Flavio Maria Ceci, Giampiero Ferraguti, Francesca Gabanella, Christian Barbato, Maria Grazia Di Certo, Luca Cavalcanti, Antonio Minni, Fabio Midulla, Luigi Tarani, Marco Fiore
Summary: COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. This study aimed to investigate the changes in NGF and BDNF levels in infected adolescents and their relationship with inflammatory biomarkers. The results showed that NGF serum content was lower in post-infected-COVID-19 individuals, and BDNF levels were higher in symptomatic and future long-COVID-19 girls. Inflammatory biomarkers and oxidative stress index remained unchanged in male and female adolescents.
Review
Behavioral Sciences
Ying Xue, Hongyan Liang, Rui Yang, Kunhong Deng, Mimi Tang, Mengqi Zhang
Summary: Neurotrophic factors play a crucial role in providing nutritional support to neurons and influencing their proliferation and survival. Recent studies have shown that these factors have opposing effects through different receptors. Understanding the complex relationship between neurotrophic factors and depression may lead to new insights into treatment approaches.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jin Seung Choung, Sohom Bhattacharjee, Jeong Pyo Son, Jong Moon Kim, Dong Sik Cho, Choon Sik Cho, MinYoung Kim
Summary: Repetitive transcranial magnetic stimulation (rTMS) is being explored as a new treatment technique for brain lesions, but the effects in animals cannot directly represent the effects in humans due to differences in size and mechanistic characteristics. This study aimed to develop a mouse rTMS device to simulate clinical application. The magnetic field intensity generated by the mouse coil was lower than that by the human coil, and the predicted simulation values matched the measured intensity in vivo. Further research using miniaturized rTMS devices for mice should be conducted to make the findings more relevant to humans.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Wei Sun, Xiao Chen, Yazi Mei, Yang Yang, Xiaoliang Li, Lei An
Summary: Fear regulation changes as a function of early life, and the involvement of prelimbic proBDNF in fear memory extinction and its mediated signaling have been investigated. By activating p75(NTR)-GluN2B signaling, high levels of prelimbic proBDNF enhance the destabilization of retrieval-dependent weak fear memory. This modification is attributed to the promotion of synaptic function and an increase in the proportion of thin-type spines. Furthermore, strong prelimbic theta- and gamma-oscillation coupling predicts the suppressive effect of juvenile proBDNF on the recall of postretrieval memory.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yanning Li, Yitong He, Haoliang Fan, Zhuo Wang, Jian Huang, Gehua Wen, Xiaohan Wang, Qiqian Xie, Pingming Qiu
Summary: Psychological stress increases glutamate content in the amygdala and activates stress hormone corticosterone secretion, impacting synaptic plasticity through the CREB/BDNF pathway, ultimately promoting depression-like behaviors.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mahshid Ebrahimnejad, Paniz Azizi, Vahide Alipour, Mohammad-Reza Zarrindast, Salar Vaseghi
Summary: This article reviews the conflicting effects of exercise on memory in rodents and discusses the underlying mechanisms. The role of neurotransmitter systems and their interaction with brain-derived neurotrophic factor (BDNF) in modulating exercise effects on memory is highlighted. The article suggests further investigation into the specific effects of different types of exercise on neurotransmitter systems and emphasizes their importance in memory modulation.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Julien Gibon, Shannon M. Buckley, Nicolas Unsain, Vesa Kaartinen, Philippe Seguela, Philip A. Barker
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Julien Gibon, Min Su Kang, Arturo Aliaga, Behrang Sharif, Pedro Rosa-Neto, Philippe Seguela, Philip A. Barker, Alexey Kostikov
BIOORGANIC & MEDICINAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Julien Gibon, Nicolas Unsain, Karine Gamache, Rhalena A. Thomas, Andres De Leon, Aaron Johnstone, Karim Nader, Philippe Seguela, Philip A. Barker
Article
Multidisciplinary Sciences
Perrine Gaub, Andres de Leon, Julien Gibon, Vincent Soubannier, Genevieve Dorval, Philippe Seguela, Philip A. Barker
Article
Neurosciences
Julien Gibon, Philip A. Barker, Philippe Seguela
Article
Biochemistry & Molecular Biology
Julien Gibon, Peng Tu, Sylvain Bohic, Pierre Richaud, Josiane Arnaud, Mike Zhu, Guylain Boulay, Alexandre Bouron
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2011)
Article
Clinical Neurology
Julien Gibon, Jean-Christophe Deloulme, Tiphaine Chevallier, Elodie Ladeveze, Djoher Nora Abrous, Alexandre Bouron
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Neurosciences
Julien Gibon, Pierre Richaud, Alexandre Bouron
Article
Multidisciplinary Sciences
Aaron D. Johnstone, Robin M. Hallett, Andres de Leon, Bruno Carturan, Julien Gibon, Philip A. Barker
Review
Clinical Neurology
S. Bohic, J. -F. Ghersi-Egea, J. Gibon, P. Paoletti, J. Arnaud, S. Hunot, A. Boom, A. Bouron
REVUE NEUROLOGIQUE
(2011)
Article
Cell Biology
Stephen D. Glasgow, Simon Labrecque, Ian Beamish, Sarah Aufmkolk, Julien Gibon, Dong Han, Stephanie N. Harris, Paul Dufresne, Paul W. Wiseman, R. Anne McKinney, Philippe Seguela, Paul De Koninck, Edward S. Ruthazer, Timothy E. Kennedy
Article
Neurosciences
Andres de Leon, Julien Gibon, Philip A. Barker
Summary: NGF and BDNF are important trophic factors for sensory neurons during development, but the signaling pathways leading to their death differ, with BDNF-dependent sensory neuron degeneration potentially involving BAX and ROS.
Article
Neurosciences
Andres de Leon, Julien Gibon, Philip A. Barker
Summary: This study reveals the pro-degenerative role of APP in the development of the sensory nervous system during development and highlights its importance in the regulation of calcium signaling in sensory neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Aaron D. Johnstone, Andres de Leon, Nicolas Unsain, Julien Gibon, Philip A. Barker