The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease

Structural basis of kynurenine 3-monooxygenase inhibition

(2013) Marta Amaral et al.   NATURE

Targeting Kynurenine 3-Monooxygenase (KMO): Implications for Therapy in Huntingtons Disease

(2012) Mathuravani A. Thevandavakkam et al.   CNS & Neurological Disorders-Drug Targets

Drosophila eye color mutants as therapeutic tools for Huntington disease

(2012) Edward W. Green et al.   FLY

Kynurenines in the mammalian brain: when physiology meets pathology

(2012) Robert Schwarcz et al.   NATURE REVIEWS NEUROSCIENCE

Actions of Xanthurenic Acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus

(2012) C.S. Copeland et al.   NEUROPHARMACOLOGY

Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

(2012) L. Pilotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

(2012) A. T. van der Goot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

(2011) Susanna Campesan et al.   CURRENT BIOLOGY

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

(2011) Levente Gellért et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Kynurenine and its metabolites in Alzheimer's disease patients

(2010) E Gulaj et al.   Advances in Medical Sciences

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors

(2010) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

(2010) David J. Bonda et al.   REDOX REPORT

Control of catalysis in flavin-dependent monooxygenases

(2009) Bruce A. Palfey et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase fromMesorhizobium lotiMAFF303099 and Its Mechanistic Implications

(2009) Kathryn M. McCulloch et al.   BIOCHEMISTRY

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

(2009) Qian Han et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives

(2009) F. Fulop et al.   CURRENT MEDICINAL CHEMISTRY

Expression analysis of novel striatal-enriched genes in Huntington disease

(2009) Gelareh Mazarei et al.   HUMAN MOLECULAR GENETICS

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

(2009) Eddy W. Yue et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo

(2009) Laura Amori et al.   JOURNAL OF NEUROCHEMISTRY

The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection

(2009) Eniko Vamos et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis

(2008) Franca Rossi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape

(2008) Jessica B. Katz et al.   IMMUNOLOGICAL REVIEWS

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum

(2008) L. Amori et al.   NEUROSCIENCE

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

(2007) L GREGOIRE et al.   BEHAVIOURAL BRAIN RESEARCH