The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Authors
Keywords
Context, Craving, Cue, Extinction, Drug priming, Drug self-administration, Reconsolidation, Reinstatement, Relapse, Review, Stress
Journal
PSYCHOPHARMACOLOGY
Volume 229, Issue 3, Pages 453-476
Publisher
Springer Nature
Online
2013-05-17
DOI
10.1007/s00213-013-3120-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Effect of Chronic Delivery of the Toll-like Receptor 4 Antagonist (+)-Naltrexone on Incubation of Heroin Craving
- (2013) Florence R. Theberge et al. BIOLOGICAL PSYCHIATRY
- Recent developments in animal models of drug relapse
- (2013) Nathan J Marchant et al. CURRENT OPINION IN NEUROBIOLOGY
- Antagonism of the dopamine D1-like receptor in mesocorticolimbic nuclei attenuates acute food deprivation-induced reinstatement of heroin seeking in rats
- (2013) Stephanie Tobin et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Different Roles of BDNF in Nucleus Accumbens Core versus Shell during the Incubation of Cue-Induced Cocaine Craving and Its Long-Term Maintenance
- (2013) X. Li et al. JOURNAL OF NEUROSCIENCE
- Memory retrieval, extinction, and reinstatement of alcohol seeking
- (2013) E.Z. Millan et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Relapse Induced by Cues Predicting Cocaine Depends on Rapid, Transient Synaptic Potentiation
- (2013) Cassandra D. Gipson et al. NEURON
- Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity
- (2013) Nicholas M. Graziane et al. NEURON
- The use of the reinstatement model to study relapse to palatable food seeking during dieting
- (2013) Donna J. Calu et al. NEUROPHARMACOLOGY
- The promise of N-acetylcysteine in neuropsychiatry
- (2013) Michael Berk et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The Promises and Pitfalls of Retrieval-Extinction Procedures in Preventing Relapse to Drug Seeking
- (2013) Kate Hutton-Bedbrook et al. Frontiers in Psychiatry
- Role of ventral subiculum in context-induced reinstatement of heroin seeking in rats
- (2012) Jennifer M. Bossert et al. ADDICTION BIOLOGY
- Role of mGluR5 neurotransmission in reinstated cocaine-seeking
- (2012) Xiusong Wang et al. ADDICTION BIOLOGY
- Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors
- (2012) Stephen V. Mahler et al. ADDICTION BIOLOGY
- Optogenetic inhibition of cocaine seeking in rats
- (2012) Michael T. Stefanik et al. ADDICTION BIOLOGY
- The role of medial prefrontal cortex in extinction and reinstatement of alcohol-seeking in rats
- (2012) Andrea L. Willcocks et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Role of Projections from Ventral Medial Prefrontal Cortex to Nucleus Accumbens Shell in Context-Induced Reinstatement of Heroin Seeking
- (2012) J. M. Bossert et al. JOURNAL OF NEUROSCIENCE
- Fos Activation of Selective Afferents to Ventral Tegmental Area during Cue-Induced Reinstatement of Cocaine Seeking in Rats
- (2012) S. V. Mahler et al. JOURNAL OF NEUROSCIENCE
- Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
- (2012) Helen C Fox et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Heroin Self-Administration Experience Establishes Control of Ventral Tegmental Glutamate Release by Stress and Environmental Stimuli
- (2012) Bin Wang et al. NEUROPSYCHOPHARMACOLOGY
- Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
- (2012) Abhiram Pushparaj et al. NEUROPSYCHOPHARMACOLOGY
- Reconsolidation of drug memories
- (2012) Barbara A. Sorg NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Tobacco addiction and the dysregulation of brain stress systems
- (2012) Adrie W. Bruijnzeel NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- The persistence of maladaptive memory: Addiction, drug memories and anti-relapse treatments
- (2012) Amy L. Milton et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior
- (2012) Courtney M. Sinclair et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Differential involvement of prelimbic and infralimbic medial prefrontal cortex in discrete cue-induced reinstatement of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) seeking in rats
- (2012) Kevin T. Ball et al. PSYCHOPHARMACOLOGY
- Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving
- (2012) Florence R. M. Theberge et al. PSYCHOPHARMACOLOGY
- Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
- (2012) Mary M. Torregrossa et al. PSYCHOPHARMACOLOGY
- Yohimbine increases opioid-seeking behavior in heroin-dependent, buprenorphine-maintained individuals
- (2012) Mark K. Greenwald et al. PSYCHOPHARMACOLOGY
- Hypothalamic Neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat
- (2012) Marsida Kallupi et al. PSYCHOPHARMACOLOGY
- Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats
- (2012) Stephen V. Mahler et al. PSYCHOPHARMACOLOGY
- A Memory Retrieval-Extinction Procedure to Prevent Drug Craving and Relapse
- (2012) Y.-X. Xue et al. SCIENCE
- Subregion-specific role of glutamate receptors in the nucleus accumbens on drug context-induced reinstatement of cocaine-seeking behavior in rats
- (2011) Xiaohu Xie et al. ADDICTION BIOLOGY
- Prazosin Effects on Stress- and Cue-Induced Craving and Stress Response in Alcohol-Dependent Individuals: Preliminary Findings
- (2011) Helen C. Fox et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- α2 Adrenergic and Imidazoline Receptor Agonists Prevent Cue-Induced Cocaine Seeking
- (2011) Rachel J. Smith et al. BIOLOGICAL PSYCHIATRY
- The Effect of N-Acetylcysteine in the Nucleus Accumbens on Neurotransmission and Relapse to Cocaine
- (2011) Yonatan M. Kupchik et al. BIOLOGICAL PSYCHIATRY
- Lesions and reversible inactivation of the dorsolateral caudate-putamen impair cocaine-primed reinstatement to cocaine-seeking in rats
- (2011) Amanda Gabriele et al. BRAIN RESEARCH
- The hypothalamus and the neurobiology of drug seeking
- (2011) Nathan J. Marchant et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
- (2011) Morgan H. James et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Integrins Modulate Relapse to Cocaine-Seeking
- (2011) A. Wiggins et al. JOURNAL OF NEUROSCIENCE
- Overexpression of CREB in the Nucleus Accumbens Shell Increases Cocaine Reinforcement in Self-Administering Rats
- (2011) E. B. Larson et al. JOURNAL OF NEUROSCIENCE
- Augmented Cocaine Seeking in Response to Stress or CRF Delivered into the Ventral Tegmental Area Following Long-Access Self-Administration Is Mediated by CRF Receptor Type 1 But Not CRF Receptor Type 2
- (2011) J. M. Blacktop et al. JOURNAL OF NEUROSCIENCE
- Chronic N-Acetylcysteine during Abstinence or Extinction after Cocaine Self-Administration Produces Enduring Reductions in Drug Seeking
- (2011) C. M. Reichel et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Interaction between the basolateral amygdala and dorsal hippocampus is critical for cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior in rats
- (2011) A. M. Wells et al. LEARNING & MEMORY
- Accumbens shell AMPA receptors mediate expression of extinguished reward seeking through interactions with basolateral amygdala
- (2011) E. Z. Millan et al. LEARNING & MEMORY
- Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
- (2011) Jennifer M Bossert et al. NATURE NEUROSCIENCE
- Opiate versus psychostimulant addiction: the differences do matter
- (2011) Aldo Badiani et al. NATURE REVIEWS NEUROSCIENCE
- Adenosine A2A Receptors in the Nucleus Accumbens Bi-Directionally Alter Cocaine Seeking in Rats
- (2011) Casey E O'Neill et al. NEUROPSYCHOPHARMACOLOGY
- Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate
- (2011) John C Umhau et al. NEUROPSYCHOPHARMACOLOGY
- Mifepristone in the Central Nucleus of the Amygdala Reduces Yohimbine Stress-Induced Reinstatement of Ethanol-Seeking
- (2011) Jeffrey A Simms et al. NEUROPSYCHOPHARMACOLOGY
- The cystine–glutamate transporter enhancer N-acetyl-l-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys
- (2011) Rayna M. Bauzo et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors
- (2011) H. Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clonidine blocks stress-induced craving in cocaine users
- (2011) Michelle L. Jobes et al. PSYCHOPHARMACOLOGY
- Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
- (2011) A. D. Lê et al. PSYCHOPHARMACOLOGY
- Translational and reverse translational research on the role of stress in drug craving and relapse
- (2011) Rajita Sinha et al. PSYCHOPHARMACOLOGY
- Linking Context with Reward: A Functional Circuit from Hippocampal CA3 to Ventral Tegmental Area
- (2011) Alice H. Luo et al. SCIENCE
- Neurobiology of the incubation of drug craving
- (2011) Charles L. Pickens et al. TRENDS IN NEUROSCIENCES
- Endogenous GDNF in ventral tegmental area and nucleus accumbens does not play a role in the incubation of heroin craving
- (2010) Mikko Airavaara et al. ADDICTION BIOLOGY
- Opioid receptors in the basolateral amygdala but not dorsal hippocampus mediate context-induced alcohol seeking
- (2010) Peter W. Marinelli et al. BEHAVIOURAL BRAIN RESEARCH
- Extinction of drug seeking
- (2010) E. Zayra Millan et al. BEHAVIOURAL BRAIN RESEARCH
- Granular Insular Cortex Inactivation as a Novel Therapeutic Strategy for Nicotine Addiction
- (2010) Benoit Forget et al. BIOLOGICAL PSYCHIATRY
- Persistent Increases in Cocaine-Seeking Behavior After Acute Exposure to Cold Swim Stress
- (2010) Kelly L. Conrad et al. BIOLOGICAL PSYCHIATRY
- Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking
- (2010) Angelica Rocha et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- A double-blind, placebo-controlled study of N-acetyl cysteine plus naltrexone for methamphetamine dependence
- (2010) Jon E. Grant et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A
- (2010) H. Sanchez et al. JOURNAL OF NEUROSCIENCE
- Accumbens Shell-Hypothalamus Interactions Mediate Extinction of Alcohol Seeking
- (2010) E. Z. Millan et al. JOURNAL OF NEUROSCIENCE
- Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats
- (2010) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Medial Dorsal Hypothalamus Mediates the Inhibition of Reward Seeking after Extinction
- (2010) N. J. Marchant et al. JOURNAL OF NEUROSCIENCE
- The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation
- (2010) F. R. M. Theberge et al. LEARNING & MEMORY
- How does PKMζ maintain long-term memory?
- (2010) Todd C. Sacktor NATURE REVIEWS NEUROSCIENCE
- Stimulation of α2-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats
- (2010) Hidetaka Yamada et al. NEUROPHARMACOLOGY
- Repeated N-Acetyl Cysteine Reduces Cocaine Seeking in Rodents and Craving in Cocaine-Dependent Humans
- (2010) Shelley L Amen et al. NEUROPSYCHOPHARMACOLOGY
- Stimulation of Medial Prefrontal Cortex Serotonin 2C (5-HT2C) Receptors Attenuates Cocaine-Seeking Behavior
- (2010) Nathan S Pentkowski et al. NEUROPSYCHOPHARMACOLOGY
- Interaction of the Basolateral Amygdala and Orbitofrontal Cortex is Critical for Drug Context-Induced Reinstatement of Cocaine-Seeking Behavior in Rats
- (2010) Heather C Lasseter et al. NEUROPSYCHOPHARMACOLOGY
- Sub-region specific contribution of the ventral hippocampus to drug context-induced reinstatement of cocaine-seeking behavior in rats
- (2010) H.C. Lasseter et al. NEUROSCIENCE
- Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system
- (2010) M. Kallupi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse
- (2010) K. Moussawi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blockade of 5-HT2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats
- (2010) Lara A. Pockros et al. PSYCHOPHARMACOLOGY
- Inactivation of the bed nucleus of the stria terminalis in an animal model of relapse: effects on conditioned cue-induced reinstatement and its enhancement by yohimbine
- (2010) Deanne M. Buffalari et al. PSYCHOPHARMACOLOGY
- Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking
- (2009) Vidhya Kumaresan et al. BEHAVIOURAL BRAIN RESEARCH
- Reinstatement of Cocaine Seeking by Hypocretin (Orexin) in the Ventral Tegmental Area: Independence from the Local Corticotropin-Releasing Factor Network
- (2009) Bin Wang et al. BIOLOGICAL PSYCHIATRY
- Role of Ventral Tegmental Area Glial Cell Line–Derived Neurotrophic Factor in Incubation of Cocaine Craving
- (2009) Lin Lu et al. BIOLOGICAL PSYCHIATRY
- Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking
- (2009) Uri Shalev et al. BRAIN RESEARCH
- The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
- (2009) M.R. Bruchas et al. BRAIN RESEARCH
- Reactivity to laboratory stress provocation predicts relapse to cocaine
- (2009) Sudie E. Back et al. DRUG AND ALCOHOL DEPENDENCE
- The limbic circuitry underlying cocaine seeking encompasses the PPTg/LDT
- (2009) Heath D. Schmidt et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Paraventricular thalamus mediates context-induced reinstatement (renewal) of extinguished reward seeking
- (2009) Adam S. Hamlin et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Basolateral amygdala involvement in memory reconsolidation processes that facilitate drug context-induced cocaine seeking
- (2009) Rita A. Fuchs et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats
- (2009) Donna R. Ramirez et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Involvement of the lateral orbitofrontal cortex in drug context-induced reinstatement of cocaine-seeking behavior in rats
- (2009) Heather C. Lasseter et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Dopamine D1 receptor antagonism in the prelimbic cortex blocks the reinstatement of heroin-seeking in an animal model of relapse
- (2009) Ronald E. See INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Lateral Hypothalamus Is Required for Context-Induced Reinstatement of Extinguished Reward Seeking
- (2009) N. J. Marchant et al. JOURNAL OF NEUROSCIENCE
- Extinction circuits for fear and addiction overlap in prefrontal cortex
- (2009) J. Peters et al. LEARNING & MEMORY
- Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization
- (2009) Eisuke Koya et al. NATURE NEUROSCIENCE
- Persistent Increase of Alcohol-Seeking Evoked by Neuropeptide S: an Effect Mediated by the Hypothalamic Hypocretin System
- (2009) Nazzareno Cannella et al. NEUROPSYCHOPHARMACOLOGY
- Separable Roles of the Nucleus Accumbens Core and Shell in Context- and Cue-Induced Alcohol-Seeking
- (2009) Nadia Chaudhri et al. NEUROPSYCHOPHARMACOLOGY
- Role of Mu- and Delta-Opioid Receptors in the Nucleus Accumbens in Cocaine-Seeking Behavior
- (2009) Diana Simmons et al. NEUROPSYCHOPHARMACOLOGY
- The neuropharmacology of relapse to food seeking: Methodology, main findings, and comparison with relapse to drug seeking
- (2009) Sunila G. Nair et al. PROGRESS IN NEUROBIOLOGY
- Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats
- (2009) Ryan K. Bachtell et al. PSYCHOPHARMACOLOGY
- Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats
- (2009) Nadia Chaudhri et al. PSYCHOPHARMACOLOGY
- The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats
- (2009) Anh Dzung Lê et al. PSYCHOPHARMACOLOGY
- Role of dopamine D1-family receptors in dorsolateral striatum in context-induced reinstatement of heroin seeking in rats
- (2009) Jennifer M. Bossert et al. PSYCHOPHARMACOLOGY
- Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats
- (2009) Xiaohu Xie et al. PSYCHOPHARMACOLOGY
- The α4β2 nicotinic acetylcholine-receptor partial agonist varenicline inhibits both nicotine self-administration following repeated dosing and reinstatement of nicotine seeking in rats
- (2009) Eoin C. O’Connor et al. PSYCHOPHARMACOLOGY
- Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear Memories
- (2009) M.-H. Monfils et al. SCIENCE
- Context-Induced Relapse of Conditioned Behavioral Responding to Ethanol Cues in Rats
- (2008) Nadia Chaudhri et al. BIOLOGICAL PSYCHIATRY
- The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans
- (2008) Lori A. Knackstedt et al. BIOLOGICAL PSYCHIATRY
- The neurocircuitry of addiction: an overview
- (2008) M W Feltenstein et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacological manipulation of memory reconsolidation: Towards a novel treatment of pathogenic memories
- (2008) Leontien Diergaarde et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking
- (2008) R. T. LaLumiere et al. JOURNAL OF NEUROSCIENCE
- Intra-Amygdala and Systemic Antagonism of NMDA Receptors Prevents the Reconsolidation of Drug-Associated Memory and Impairs Subsequently Both Novel and Previously Acquired Drug-Seeking Behaviors
- (2008) A. L. Milton et al. JOURNAL OF NEUROSCIENCE
- Infralimbic Prefrontal Cortex Is Responsible for Inhibiting Cocaine Seeking in Extinguished Rats
- (2008) J. Peters et al. JOURNAL OF NEUROSCIENCE
- Glutamate transmission in addiction
- (2008) Peter W. Kalivas et al. NEUROPHARMACOLOGY
- The runway model of drug self-administration
- (2008) Aaron Ettenberg PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Context-induced relapse to drug seeking: a review
- (2008) H. S Crombag et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Nucleus accumbens shell and core involvement in drug context-induced reinstatement of cocaine seeking in rats
- (2008) Rita A. Fuchs et al. PSYCHOPHARMACOLOGY
- Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system
- (2008) Van A. Redila et al. PSYCHOPHARMACOLOGY
- Renewal of extinguished cocaine-seeking
- (2007) A.S. Hamlin et al. NEUROSCIENCE
- The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse
- (2007) J.L. Rogers et al. NEUROSCIENCE
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started