Article
Environmental Sciences
Ying Liu, Yifei Le, Mengting Xu, Wanyue Wang, Hang Chen, Quan Zhang, Cui Wang
Summary: This study investigated the physiological disturbance of OPEs on adipose tissue and found that certain compounds may induce inflammation and insulin resistance. Mechanistic investigations revealed that these compounds affect lipolysis and glucose uptake.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Shim Han, Ilavenil Soundharrajan, Mariadhas Valan Arasu, Dahye Kim, Ki-Choon Choi
Summary: This study investigated the effects of Leuconostoc citreum (LSC) cell-free metabolites on adipogenesis, lipogenesis, and lipolysis in 3T3-L1 adipocytes. The results showed that LSC treatment reduced lipid droplet accumulation and the expression of key adipogenic and lipogenic markers while increasing lipolysis. Additionally, LSC treatment elevated adiponectin levels, suggesting its potential as a novel probiotic strain for treating obesity and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Katarzyna Szkudelska, Monika Okulicz, Tomasz Szkudelski
Summary: BPA enhances insulin action and lipolysis response to epinephrine in adipocytes, but has no effect on adipokine secretion.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kelsie J. Anson, Giulia A. Corbet, Amy E. Palmer
Summary: In this study, the researchers investigated how changes in intracellular zinc ion levels affect kinase signaling pathways using fluorescent biosensors and cell perturbations. The results showed that zinc ion fluctuations are not toxic and do not activate stress-dependent kinase signaling. Additionally, the study demonstrated that while zinc ions can inhibit phosphatases, ERK and Akt are primarily activated through upstream signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Huong Giang Pham, Trang Thi Huyen Dang, Jong Won Yun
Summary: Salvianolic acid B (Sal B) promotes white fat browning, suppresses lipogenesis, and enhances lipolysis in white adipocytes, suggesting its beneficial effects in preventing and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Ranran Wang, Lulu Wei, Junaid Wazir, Li Li, Shiyu Song, Kai Lin, Wenyuan Pu, Chen Zhao, Zhonglan Su, Quan Zhao, Hongwei Wang
Summary: Curcumin improves adipose atrophy in cancer cachexia by inhibiting the cAMP/PKA/CREB signaling pathway. The study shows that curcumin protects mice with C26 tumors and cachexia from weight loss and adipose atrophy, reducing levels of free fatty acids and increasing triglyceride levels. Curcumin also ameliorates CL316243-induced adipose atrophy and inhibits hormone-mediated PKA and CREB activation.
Article
Pharmacology & Pharmacy
Huili Zhu, Xiaoqian Liu, Xiaoxuan Wang, Yulei Li, Fang Ma, Bo Tan, Peilan Zhou, Fenghua Fu, Ruibin Su
Summary: This study reveals a potential mechanism by which G beta gamma subunits regulate DOM-induced head-twitch response (HTR) and suggests that inhibitors targeting G beta gamma subunits may inhibit the hallucinogenic effects of 5-HT2A receptor agonists.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Yang Hu, Parivash Afradiasbagharani, Ranli Lu, Lifeng Liu, Lynn A. Birch, Gail S. Prins
Summary: The MEK/ERK and Rho/Rho kinase signaling pathways play crucial roles in prostate growth and branching during development, with MLCK-regulated MLC-P potentially serving as a central downstream target of both pathways in regulating prostate morphogenesis. Experiments demonstrated that inhibiting these pathways significantly inhibited prostate growth and blocked branching morphogenesis, highlighting their importance in prostate development.
Article
Biochemistry & Molecular Biology
Jing Yu, Jiabing Zhu, Jian Deng, Jing Shen, Fukuan Du, Xu Wu, Yu Chen, Mingxing Li, Qinglian Wen, Zhangang Xiao, Yueshui Zhao
Summary: The study demonstrates that activation of DRD1 signaling can promote lipolysis and browning of adipocytes, reducing adipocyte size and increasing the release of fatty acids, providing new strategies for obesity treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yu-Hong Yang, Yi-Ming Hao, Xiao-Fang Liu, Xiang Gao, Bao-Zhen Wang, Koretaro Takahashi, Lei Du
Summary: The study showed that DHA-PL and EPA-PL inhibited TNF-alpha-induced lipolysis, increased DHA and EPA content in adipocytes, and regulated metabolic pathways by activating the SIRT1 pathways. Additionally, they improved glucose metabolism by enhancing glucose uptake and transporter translocation.
Article
Biochemistry & Molecular Biology
Erica Sogo, Siqi Zhou, Haruna Haeiwa, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Takuya Yamamoto, Mikio Yamano, Kazuichi Sakamoto
Summary: This study demonstrates that amber extract can induce lipolysis in mouse 3T3-L1 cells by reducing triglyceride and glucose storage, increasing glycerol release, enhancing lipolysis-related gene expression, and regulating adipocytokines. These findings highlight the potential of amber extract in treating obesity-related diseases.
Article
Agriculture, Dairy & Animal Science
Shifeng Pan, Lin Zhang, Zhuang Liu, Hua Xing
Summary: The study revealed that MSTN can inhibit lipid accumulation and promote lipolysis in porcine subcutaneous preadipocytes, mainly through activating the crosstalk between ERK1/2 and PKA signaling pathways.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiahan Xie, Huimin Liu, Wandi Yin, Sitong Ge, Zhibo Jin, Mingzhu Zheng, Dan Cai, Meihong Liu, Jingsheng Liu
Summary: This study found that zeaxanthin (ZEA) induces structural and metabolic remodeling of lipid droplets (LDs) by activating beta 3-adrenergic receptor (β3-AR) signaling and enhancing PLIN5-mediated LD-mitochondrion interactions, thereby enhancing oxidative capacity and potentially serving as a nutritional intervention for the prevention and treatment of obesity and associated metabolic syndrome.
Article
Oncology
Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh, Andrew Fong, Lin Li, Shira Ronen, Shuyang Chen, Pauline Funchain, Ying Ni, Joshua Arbesman
Summary: The study found that disruptive MC1R variants associated with melanomagenesis are less frequently found in patients with several cancers. Further exploration revealed that breast cancer tissue shows significantly higher MC1R expression than normal breast tissue, and knocking down MC1R significantly reduces cell proliferation in breast cancer cells. The study revealed a new association between MC1R and breast cancer, and caution is advised in using MC1R-enhancing/activating therapies as they might promote tumorigenesis in certain contexts.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chih-Chan Lien, Wei-Hsian Yin, De-Ming Yang, Luen-Kui Chen, Chien-Wei Chen, Shui-Yu Liu, Ching-Fai Kwok, Low-Tone Ho, Chi-Chang Juan
Summary: Research indicates that endothelin-1 (ET-1) can induce lipolysis in adipocytes through activation of multiple signaling pathways, including ERK, HSL, and CaMKIII pathways.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)