Mimicking Parkinson’s Disease in a Dish: Merits and Pitfalls of the Most Commonly used Dopaminergic In Vitro Models

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells

(2017) Fernanda M. Lopes et al.   NEUROTOXICITY RESEARCH

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

An updated review of Parkinson's disease genetics and clinicopathological correlations

(2016) M. Ferreira et al.   ACTA NEUROLOGICA SCANDINAVICA

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Carnosic Acid Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells by Inducing Autophagy Through an Enhanced Interaction of Parkin and Beclin1

(2016) Chia-Yuan Lin et al.   MOLECULAR NEUROBIOLOGY

Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

(2016) G. Martella et al.   NEUROBIOLOGY OF DISEASE

Non motor subtypes and Parkinson's disease

(2016) Anna Sauerbier et al.   PARKINSONISM & RELATED DISORDERS

Evaluation of Models of Parkinson's Disease

(2016) Shail A. Jagmag et al.   Frontiers in Neuroscience

6-OHDA-Induced Changes in Parkinson`s Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells

(2015) Tomasz Maciej Stępkowski et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

Neurotoxin Mechanisms and Processes Relevant to Parkinson’s Disease: An Update

(2015) Juan Segura-Aguilar et al.   NEUROTOXICITY RESEARCH

Isolation, Culture and Long-Term Maintenance of Primary Mesencephalic Dopaminergic Neurons From Embryonic Rodent Brains

(2015) Maria Weinert et al.   Jove-Journal of Visualized Experiments

Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function

(2015) Lei Wei et al.   Translational Neurodegeneration

Analysis of the Catecholaminergic Phenotype in Human SH-SY5Y and BE(2)-M17 Neuroblastoma Cell Lines upon Differentiation

(2015) Roberta Filograna et al.   PLoS One

Cell-based assays for Parkinson's disease using differentiated human LUHMES cells

(2014) Xiao-min Zhang et al.   ACTA PHARMACOLOGICA SINICA

Cannabidiol Exposure During Neuronal Differentiation Sensitizes Cells Against Redox-Active Neurotoxins

(2014) Patrícia Schönhofen et al.   MOLECULAR NEUROBIOLOGY

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons

(2014) Elizabeth M. Hartfield et al.   PLoS One

Studying neurodegenerative diseases in culture models

(2014) Johannes C.M. Schlachetzki et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons

(2014) Vannary Tieng et al.   STEM CELLS AND DEVELOPMENT

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases

(2014) Stefan Schildknecht   ALTEX-Alternatives to Animal Experimentation

Primary Culture of Mouse Dopaminergic Neurons

(2014) Florence Gaven et al.   Jove-Journal of Visualized Experiments

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Immortality of cell lines: challenges and advantages of establishment

(2013) Muhammad Irfan Maqsood et al.   CELL BIOLOGY INTERNATIONAL

Organotypic cultures as tools for optimizing central nervous system cell therapies

(2013) Nicolas Daviaud et al.   EXPERIMENTAL NEUROLOGY

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

Modeling human neurological disorders with induced pluripotent stem cells

(2013) Yoichi Imaizumi et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells

(2013) Anja Hafner Pišlar et al.   NEUROPHARMACOLOGY

Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson’s disease

(2013) N. Daviaud et al.   NEUROSCIENCE

Genetics of Parkinson's disease: the yield

(2013) Marianna Spatola et al.   PARKINSONISM & RELATED DISORDERS

Non-Motor and Motor Features in LRRK2 Transgenic Mice

(2013) Zoë Bichler et al.   PLoS One

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

(2013) Lars Brichta et al.   TRENDS IN NEUROSCIENCES

Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling

(2013) M G Thomas et al.   Cell Death & Disease

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

(2012) L. Tonges et al.   BRAIN

Redefining Parkinson’s Disease Research Using Induced Pluripotent Stem Cells

(2012) Jiali Pu et al.   Current Neurology and Neuroscience Reports

Therapies in Parkinsonʼs disease

(2012) Joseph Jankovic et al.   CURRENT OPINION IN NEUROLOGY

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Differential Toxicity of 6-Hydroxydopamine in SH-SY5Y Human Neuroblastoma Cells and Rat Brain Mitochondria: Protective Role of Catalase and Superoxide Dismutase

(2012) Javier Iglesias-González et al.   NEUROCHEMICAL RESEARCH

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line

(2011) Diana Scholz et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death

(2011) Alison I Bernstein et al.   Molecular Neurodegeneration

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Evolution of Extra-Nigral Damage Predicts Behavioural Deficits in a Rat Proteasome Inhibitor Model of Parkinson's Disease

(2011) Anthony C. Vernon et al.   PLoS One

Organotypic Cultures as a Model of Parkinson´s Disease. A Twist to an Old Model

(2011) Katja Stahl et al.   TheScientificWorldJOURNAL

Why have we failed to achieve neuroprotection in Parkinson's disease?

(2010) C. Warren Olanow et al.   ANNALS OF NEUROLOGY

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies

(2010) Fernanda Martins Lopes et al.   BRAIN RESEARCH

Optimizing the generation of stable neuronal cell lines via pre-transfection restriction enzyme digestion of plasmid DNA

(2010) Grant Stuchbury et al.   CYTOTECHNOLOGY

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration

(2010) Zhi Dong Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

An organotypic culture model to study nigro-striatal degeneration

(2010) Fabio Cavaliere et al.   JOURNAL OF NEUROSCIENCE METHODS

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

(2010) Oliver Cooper et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Parkinson's disease: a model dilemma

(2010) M. Flint Beal   NATURE

Persistent organochlorine pesticides in serum and risk of Parkinson disease

(2010) M. G. Weisskopf et al.   NEUROLOGY

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Regulation of monoamine transporters: Role of transporter phosphorylation

(2010) Sammanda Ramamoorthy et al.   PHARMACOLOGY & THERAPEUTICS

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Elevated Serum Pesticide Levels and Risk of Parkinson Disease

(2009) Jason R. Richardson et al.   ARCHIVES OF NEUROLOGY

Can cellular models revolutionize drug discovery in Parkinson's disease?

(2009) Birgitt Schüle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Peroxidase Mechanism of Lipid-dependent Cross-linking of Synuclein with Cytochromec

(2009) Hülya Bayır et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Why SH-SY5Y cells should be differentiated

(2009) Dirk W. Luchtman et al.   NEUROTOXICOLOGY

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

(2009) Stefan Schildknecht et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The proteome of the human neuroblastoma cell line SH-SY5Y: An enlarged proteome

(2008) Kambiz Gilany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Selective Activation of p38 Mitogen-Activated Protein Kinase in Dopaminergic Neurons of Substantia Nigra Leads to Nuclear Translocation of p53 in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice

(2008) S. Karunakaran et al.   JOURNAL OF NEUROSCIENCE

In-tube transfection improves the efficiency of gene transfer in primary neuronal cultures

(2008) Marc W. Halterman et al.   JOURNAL OF NEUROSCIENCE METHODS

Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth

(2008) Nicholas M. Radio et al.   NEUROTOXICOLOGY

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

Relevance of in vitro neurotoxicity testing for regulatory requirements: Challenges to be considered

(2008) Anna K. Bal-Price et al.   NEUROTOXICOLOGY AND TERATOLOGY

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH

Nitration of soluble proteins in organotypic culture models of Parkinson's disease

(2007) Trine R. Larsen et al.   NEUROCHEMISTRY INTERNATIONAL